A surface-tension-driven fluidic network for precise enzyme batch-dispensing and glucose detection

Scalable attoliter monodisperse droplet formation using multiphase nano-microfluidics

“…Many areas employ multiphase droplet-based microfludics (Shui et al 2007;Gunther and Jensen 2006), including inkjet printers (van Dam and Le Clerc 2004), systems for separation of biochemical samples (Fujimura et al 2003), manipulation of biomolecules (Lo et al 2004), bio-sensing (Wang et al 2006), single cell analysis (Yong et al 2010), enhanced mixing for bio-sample reactions (Yang et al 2006), biomolecular detection (Tseng et al 2004), drug delivery devices (Chung et al 2008), dairy analysis (Skurtys and Aguilera 2008), microelectronic cooling (Nilson et al 2006), explosives detection (Piorek et al 2007), bubble computing (Prakash and Gershenfeld 2007), interfacial tension measurement (Xu et al 2008), and analysis of emulsions, foams, and bubble coalescence (Kralj et al 2005). As general characteristics, the droplets should be as stable, monodisperse, reproducible, and controllable as possible.…”

Surface tension driven flow for open microchannels with different turning angles

“…Due to the limited space on the chip, the use of serpentine configurations (Liu et al 2000), H-type (Yang et al 2006), Y-Type (Wang et al 2007;Gobby et al 2001), connected parallel microchannels (Tseng et al 2004), converging/diverging channels or adding geometric complexity with helical microchannels (Beebe et al 2001) were proposed to enhance mixing or to distribute liquids with turns within microchannel flow paths, and these channels were of close type or open type. Turning of flow inevitably results in considerable change of flow structure, thereby leading to interesting flow phenomenon and flow resistance for effective design of micro-flow devices.…”

“…Although the channel surface properties (Kirby and Hasselbrink 2004a, b;Herr et al 2000) affected the performance of the microchannels and controlled the electroosmotic flow, resultant electric fields and velocity fields were of interest for fundamental studies. in separating the biochemical samples using electrophoresis (Fujimura et al 2003), in manipulating neuron outgrowth or in working with bio-sensor applications (Lo et al 2004), in manipulating DNA molecules (Wang et al 2006), in enhance mixing for bio-sample reactions (Yang et al 2006), in detecting glucose (Tseng et al 2004) and in cooling of microelectronics (Nilson et al 2006). However, very few fundamental studies have been reported on open microchannel flow systems driven by surface tension.…”

Functionalization of polymerized 3D microstructures for biological applications

“…The IR absorption spectra measured on the UV-polymerized and on the TPP samples were normalized using the treatment-unaffected 1608 cm -1 band of SU-8 (Tseng et al 2004). The amount of residual epoxide groups was compared by the area of the band at 914 cm -1 , characteristic for the epoxy ring vibration (Tseng et al 2004).…”

“…The amount of residual epoxide groups was compared by the area of the band at 914 cm -1 , characteristic for the epoxy ring vibration (Tseng et al 2004). …”