A surface plasmon resonance based integrated optical sensor

Surface plasmon interferometer in silicon-on-insulator: novel concept for an integrated biosensor

“…Driven by the vision of a laboratory on a chip and its impact in numerous applications such as detection, biosensing, kinetic and binding studies and point-of-care diagnostics, extensive work has been done to miniaturize SPR biosensors. In the past decade, several integrated optical SPR sensors have been demonstrated [2,3,4], in which thin gold films serving as a platform for the attachment of sensing films are deposited on top of an integrated optical waveguide system. However, all integrated SPR sensors that have been investigated so far are fabricated in a material system with a low refractive index contrast [2,3,4,5], keeping typical dimensions of waveguides and optical components too large for miniaturization and consequent lab on chip applications.…”

“…In the past decade, several integrated optical SPR sensors have been demonstrated [2,3,4], in which thin gold films serving as a platform for the attachment of sensing films are deposited on top of an integrated optical waveguide system. However, all integrated SPR sensors that have been investigated so far are fabricated in a material system with a low refractive index contrast [2,3,4,5], keeping typical dimensions of waveguides and optical components too large for miniaturization and consequent lab on chip applications. Working with a high refractive index material system such as silicon-on-insulator is a more straight-forward approach to meet the requirements for high-level integration and high-throughput fabrication.…”

Adaptive spatial resolution: application to surface plasmon waveguide modes

“…The high sensitivity of this technique to surface phenomena makes it ideal for use in real-time and label-free biosensors where very small changes in refractive index must be detected. In the past decade, several integrated optical SPR sensors have been demonstrated (Harris and Wilkinson 1995;Homola et al 1997;Čtyrocký et al 1999), in which thin gold films serving as a platform for the attachment of sensing films are deposited on top of an integrated optical waveguide system. However, all integrated SPR sensors that have been investigated so far are fabricated in a material system with a low refractive index contrast, keeping typical dimensions of waveguides and optical components too large for miniaturization and consequent labon-chip applications.…”

Porous Silicon Integrated Photonic Devices for Biochemical Optical Sensing

“…Fluorescence detection has been the main approach in medical diagnostic, biotechnology and drug discovery for a long time. Recently, a new class of optical label-free sensors has been proposed, which uses direct optical methods (photoluminescence (Chan et al, 2001), surface plasmon resonance (SPR) (Homola et al, 1997;Jung et al, 1998), reflectivity (Mace et al, 2006), interference (Brandenburg & Henninger, 1994)) and label-free natural probes such as DNA sequences and proteins. Fig.…”