A Surface-Based Approach to Quantify Local Cortical Gyrification

Schaer, Marie; Cuadra, Meritxell Bach; Tamarit, Lucas; Lazeyras, François; Eliez, Stéphan; Thiran, Jean-Philippe

doi:10.1109/tmi.2007.903576

Cited by 487 publications

(524 citation statements)

References 75 publications

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“…Cortical thickness is defined as the distance between the pial and the white surface and is calculated by finding the shortest direct path between them (Fischl and Dale, 2000). The local gyrification index (lGI) is a vertex-wise measure elucidating gyral complexity and is computed according to the method described in (Schaer et al, 2008).…”

Section: Magnetic Resonance Images (Mris) Acquisition and Processingmentioning

confidence: 99%

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Morphological brain changes associated with negative symptoms in patients with 22q11.2 Deletion Syndrome

Mihailov

Padula

Scariati

et al. 2017

Schizophrenia Research

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Approximately 30% of individuals with 22q11.2 Deletion Syndrome (22q11DS) develop schizophrenia during adolescence/early adulthood, making this syndrome a model for the disorder. Furthermore, negative symptoms exist in up to 80% of patients diagnosed with 22q11DS. The present study aims to uncover morphological brain alterations associated with negative symptoms in a cohort of patients with 22q11DS who are at-risk for developing schizophrenia. A total of 71 patients with 22q11DS aged 12 to 35 (54% females) with no past or present diagnosis of a schizophrenia were included in the study. Psychotic symptom scores were used to divide patients into subgroups by means of a cluster analysis. Three major subgroups were evident: patients with low negative and positive symptoms; patients with high negative symptoms and low positive symptoms; and patients with high negative and positive symptoms. Cortical volume, thickness and gyrification were compared between subgroups using FreeSurfer software. Results showed that patients with high negative symptoms, compared to those with low negative symptoms, have decreased gyrification in the medial occipito-temporal (MOT) and lateral temporo-parietal (LTP) cortices of the left hemisphere, and in the medial temporal (MT)/posterior cingulate (PCC) cortices of the right hemisphere. These findings suggest that high negative symptoms are associated with gyrification reductions predominantly in medial occipital and temporal regions, which are areas implicated in social cognition and early visual processing. Furthermore, as cortical folding develops in utero and during the first years of life, reduced gyrification may represent an early biomarker predicting the development of negative symptoms.

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Section: Magnetic Resonance Images (Mris) Acquisition and Processingmentioning

confidence: 99%

“…Thickness and volume values were then smoothed using a full width at a half maximum (FWHM) of 10 mm. As the lGI values are already smoothed because of the way they are computed (Schaer et al, 2008), a smoothing at a FWHM of 5 mm was used. Gender and age were added as covariates in the model.…”

Section: Statistical Analysesmentioning

confidence: 99%

Morphological brain changes associated with negative symptoms in patients with 22q11.2 Deletion Syndrome

Mihailov

Padula

Scariati

et al. 2017

Schizophrenia Research

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“…Details of the lGI computation can be found in the validation paper (Schaer et al, 2008) and at https://surfer.nmr.mgh.harvard.edu/fswiki/LGI.…”

Section: Local Gyrification Index (Lgi)mentioning

confidence: 99%

“…the ratio between the folded cortical surface and an outer cerebral surface tightly warping the brain without entering the sulci (Zilles et al, 1988). One of the authors of the present paper (MS) has developed an automated method for measuring vertex-wise gyrification in threedimensional (3D) space across the entire cortex based on magnetic resonance imaging (MRI) data (Schaer et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Reduced brain cortical folding in schizophrenia revealed in two independent samples

Nesvåg

Schaer

Haukvik

et al. 2014

Schizophrenia Research

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The cerebral cortex is highly convoluted, and principal folding patterns are determined early in life. Degree of cortical folding in adult life may index aberrations in brain development. Results from previous studies of cortical folding in schizophrenia are inconsistent. Here we investigated cortical folding patterns in the hitherto largest sample of patients with schizophrenia drawn from two independent cohorts. Magnetic resonance imaging scans were acquired from 207 patients and 206 healthy subjects recruited to two separate research projects in Sweden and Norway. Local gyrification index (lGI) was estimated continuously across the cortex using automated methods. Group differences in lGI were analyzed using general linear models. Patients had lower lGI in three large clusters of the cortex with peak differences found in the left precentral gyrus, right middle temporal gyrus, and right precuneus. Similar, although not completely overlapping results were found when the two cohorts were analyzed separately. There were no significant interaction effects between age and diagnosis and gender and diagnosis. The finding of reduced degree of folding in large regions of the cerebral cortex across two independent samples indicates that reduced gyrification is an inherent feature of the brain pathology in schizophrenia.

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“…18 However, curvature-based approaches are highly dependent on surface configuration and are sensitive to noise. The lGI, 19 a 3D extension of the GI, is a newly developed automated method for locating regionally specific changes in gyrification. This measure is able to quantify the amount of cortical surface invaginated in the sulci and measure the spatial frequency of cortical gyrification and the depth of the sulci.…”

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confidence: 99%

Reduced Cortical Folding in Mental Retardation

Zhang¹,

Zhou²,

Yu³

et al. 2010

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:MR is a developmental disorder associated with impaired cognitive functioning and deficits in adaptive behavior. With a 2D region of interestϪbased GI, a preliminary study reported significantly reduced gyrification in the prefrontal lobe in MR. The purpose of this study was to further investigate the abnormalities of cortical gyrification in MR and to explore the possible causes of these abnormalities.

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A Surface-Based Approach to Quantify Local Cortical Gyrification

Cited by 487 publications

References 75 publications

Morphological brain changes associated with negative symptoms in patients with 22q11.2 Deletion Syndrome

Morphological brain changes associated with negative symptoms in patients with 22q11.2 Deletion Syndrome

Reduced brain cortical folding in schizophrenia revealed in two independent samples

Reduced Cortical Folding in Mental Retardation

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