A supramolecular assembly strategy for hydrophilic drug delivery towards synergistic cancer treatment

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

“…Apart from hydrophobic molecules, recent research indicates that it is feasible for Ce6 to self-assemble with hydrophilic molecules by virtue of its three ionizable carboxylic acids. [35] The strong interactions of hydrogen bonds and electrostatic interaction can facilitate stable coassembly of Ce6 and hydrophilic molecules under certain circumstances.…”

“…Chemotherapy, ROS-responsiveness [59] Palbociclib dimer linked with thioketal linker Chemotherapy, ROSresponsiveness [62] Dimeric CPT and lactose linked with aromatized thioacetal Chemotherapy, ROS-responsiveness [64] Tirapazamine Chemotherapy [35] Tyroserleutide (YSL) Chemotherapy [68] 1,1′-dioctadecyl-3,3,3′,3′tetramethylindotricarbocyanine iodide (DiR)…”

“…For example, Qu and co-workers reported that Ce6 can co-assemble with hydrophilic anticancer agent tirapazamine, which is dominated by hydrogen bonds and the ionization degree of drug molecules. [35] The self-assembled nanoparticles extensively improve the in vivo bioavailability of hydrophilic drugs and effectively inhibit the progression and metastasis of breast cancer via promising synergistic effects.…”

A supramolecular assembly strategy towards organic luminescent materials

“…More importantly, supramolecular complexes are endowed with diverse properties and complex structures compared with their components. Therefore, it has a wide range of applications in catalysis, 1,2 artificial photosynthesis, 3,4 drug delivery, 5,6 detection 7,8 and other fields. In particular, when applied to the field of luminescence, different photophysical processes such as fluorescence, 9 room-temperature phosphorescence (RTP), 10,11 energy transfer 12 and electron transfer 13 processes can be regulated by supramolecular strategies, so that different luminescence and stimulus response (pH, 14 light, 15 temperature, 16 pressure, 17 etc. )…”

Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury

“…This increase in complexity and resource consumption is a direct consequence of these additional functionalities. 24 Recently, biomimetic nanomedicines have emerged as a means of propelling advancements in the field of drug delivery. The cell membrane-coated nanoparticle is a biomimetic nanoengineering approach that involves the encapsulation of core material within a membrane derived from a specific source cell.…”