A supramolecular approach to construct a hydrolase mimic with photo-switchable catalytic activity

Zhao, Yanan; Lei, Bingqian; Wang, Mengfan; Qi, Wei; Su, Rongxin; He, Zhimin

doi:10.1039/c8tb00448j

Cited by 59 publications

(74 citation statements)

References 36 publications

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“…Among these strategies, using light to stimulate the nanozyme catalysis is of great promise due to the efficient control with spatial and temporal precision as well as environmental friendliness. To fulfill this promise, highly efficient photoresponsive nanomaterials have been investigated for mimicking natural enzymes in recent years. − For example, Xia et al demonstrated that the peroxidase-like activity of gold nanoparticles (AuNPs) could be enhanced by photoinduced hot electrons for the catalytic oxidation of 3,3′,5,5′-tetramethylbenzydine (TMB) with hydrogen peroxide (H 2 O 2 ) …”

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confidence: 99%

Light-Responsive Metal–Organic Framework as an Oxidase Mimic for Cellular Glutathione Detection

et al. 2019

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Nanomaterials with enzyme-like characteristics (nanozymes) have been developed to mimic enzymes because of their low cost, high stability, and large-scale production. By using light as an external stimulation, one can modulate nanozymes’ catalytic activities with controlled spatial and temporal precision. A few inorganic photoactive materials have been investigated to construct light-responsive oxidase-like nanozymes. However, these materials suffered from limited absorbance of visible light. To address this challenge, herein we have developed a photosensitized metal–organic framework (PSMOF) by using a derivative of Ru(bpy)3 2+ with stronger visible-light absorption as a PS linker. The PSMOF exhibited excellent oxidase-like activity, which could be modulated by switching light on and off. Moreover, the PSMOF was used to detect glutathione levels in both normal and cancer cells with good selectivity and high sensitivity. This study not only provides a smart strategy to modulate nanozymes’ activities but also broadens the sensing applications of nanozymes.

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confidence: 99%

Light-Responsive Metal–Organic Framework as an Oxidase Mimic for Cellular Glutathione Detection

et al. 2019

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“…In the case of O -nitrobenzyl, the UV-induced photo-redox cleavage would generate O -nitrosobenzaldehyde that cannot reform the original O -nitrobenzyl moiety. To further pursue efficient and reversible photo-responsiveness of polypeptide nano-assemblies, some research groups have designed smart nanoparticle systems, which rely on photo-isomerizable functionalities, such as azobenzene and spiropyran [ 40 , 75 , 76 , 77 , 78 , 90 , 91 , 92 ].…”

Section: Photo-chemistry Of Light-responsive Polypeptide Nanopartimentioning

confidence: 99%

“…In addition to biomedical applications, photo-responsive polypeptides have been used in the field of catalysis as well. He and coworkers designed a peptide-based artificial hydrolase, which consisted of a catalytic histidine residue and a photo-responsive azobenzene group in the peptide chain ( Figure 10 ) [ 77 ]. Before UV irradiation, the peptide exhibited an antiparallel β -sheet conformation, enabling self-assembly into a peptide fibril.…”

Section: Properties and Applicationsmentioning

confidence: 99%

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Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies

Tang

Sun

2018

Micromachines

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Stimuli-responsive polymeric materials have attracted significant attention in a variety of high-value-added and industrial applications during the past decade. Among various stimuli, light is of particular interest as a stimulus because of its unique advantages, such as precisely spatiotemporal control, mild conditions, ease of use, and tunability. In recent years, a lot of effort towards the synthesis of a biocompatible and biodegradable polypeptide has resulted in many examples of photo-responsive nanoparticles. Depending on the specific photochemistry, those polypeptide derived nano-assemblies are capable of crosslinking, disassembling, or morphing into other shapes upon light irradiation. In this review, we aim to assess the current state of photo-responsive polypeptide based nanomaterials. Firstly, those ‘smart’ nanomaterials will be categorized by their photo-triggered events (i.e., crosslinking, degradation, and isomerization), which are inherently governed by photo-sensitive functionalities, including O-nitrobenzyl, coumarin, azobenzene, cinnamyl, and spiropyran. In addition, the properties and applications of those polypeptide nanomaterials will be highlighted as well. Finally, the current challenges and future directions of this subject will be evaluated.

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“…Therefore, the development of artificial enzymes has drawn increasinga ttention. [5] The fabrication of artificiale nzymes has been based on metal-organic frameworks (MOFs), [6,7] polymers, [8] inorganic materials, [9] peptides, [10][11][12][13][14] and amino acid de-rivatives. [15,16] On the one hand, aminoa cids are the active sites of some natural enzymes, such as hemoproteins [17] and hydrogenase.…”

Section: Introductionmentioning

confidence: 99%

Construction of Supramolecular Nanostructures with High Catalytic Activity by Photoinduced Hierarchical Co‐Assembly

Yang

Wang

et al. 2019

Chemistry A European J

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Inspired by natural enzymes, hierarchical catalytic supramolecular nanostructuresw ere developed by the coassembly of hemin and glucose oxidase (or Au NPs) with the photosensitive ferrocene-tyrosine (Fc-Y) molecule. Illuminated by white light, the Fc-Y moleculesa re polymerized and co-assemblew ith hemin into truncated polyhedrons. The Au NPs grew in situ at the surface of the co-assembled polyhedrons, achieving ordered supramolecular nanostructures. Becauset he Au NPs can serve as an artificial glucose oxidase and the hemin could act as ap eroxidase mimic, the supra-molecular hybrid nanostructures were used to mimicn atural enzymes and catalyzet he glucosec onversionc ascade reaction. The hybrid Au NPs@Fc-Y&hemin polyhedrons showed superior catalytic activity,g ood reusability,a nd maintained the catalytic activity over aw ide temperaturea nd pH range. The study demonstrates af easible strategy to construct hierarchicalc o-assembled supramolecular nanostructures as multi-enzyme mimics,w ith potential applications in biocatalysis and biosensing.

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A supramolecular approach to construct a hydrolase mimic with photo-switchable catalytic activity

Abstract: A supramolecular artificial hydrolase with photo-switchable catalytic activity was developed by the introduction of a photo-responsive group in peptide, which leads to the assembly/disassembly of the peptide nanofibers.

Cited by 59 publications

References 36 publications

Light-Responsive Metal–Organic Framework as an Oxidase Mimic for Cellular Glutathione Detection

Light-Responsive Metal–Organic Framework as an Oxidase Mimic for Cellular Glutathione Detection

Progress in Photo-Responsive Polypeptide Derived Nano-Assemblies

Construction of Supramolecular Nanostructures with High Catalytic Activity by Photoinduced Hierarchical Co‐Assembly

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