“…Antibiotics are considered the most widely used and effective antimicrobial agents, including moxifloxacin, , trimethoprim, tirapazamine, azelaic acid, ofloxacin, chloramphenicol, tetracycline, curcumin (Cur), doxycycline, berberine hydrochloride, chlorhexidine, clofazimine, trojan, amoxicillin, and vancomycin . However, several inherent limitations have greatly impeded their antibacterial efficacy, such as their poor targeting, antibacterial activity, solubility, biosafety, and susceptibility to AMR.…”