A supportive care intervention for people with metastatic melanoma being treated with immunotherapy: a pilot study assessing feasibility, perceived benefit, and acceptability

Lacey, Judith; Lomax, Anna J; McNeil, Catriona M.; Marthick, Michael; Levy, David; Kao, Steven; Nielsen, Theresa; Dhillon, Haryana M.

doi:10.1007/s00520-018-4524-3

Cited by 31 publications

(87 citation statements)

References 32 publications

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“…Ten studies [ 24 , 26 , 27 , 32 , 35 , 37 , 38 , 39 , 44 , 50 , 70 ] showed small improvements on youth weight status as measured by BMI, the BMI z-scores, or percent prevalence for being overweight/obese. A reduction was observed by a difference between groups (intervention vs. control) of at least 0.1 kg/m 2 , or by a 1.7% decrease on the prevalence of being overweight/obese from baseline to post-intervention/follow-up assessments.…”

Section: Resultsmentioning

confidence: 99%

Impact of Strategies for Preventing Obesity and Risk Factors for Eating Disorders among Adolescents: A Systematic Review

et al. 2020

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An effective behavior change program is the first line of prevention for youth obesity. However, effectiveness in prevention of adolescent obesity requires several approaches, with special attention paid to disordered eating behaviors and psychological support, among other environmental factors. The aim of this systematic review is to compare the impact of two types of obesity prevention programs, inclusive of behavior change components, on weight outcomes. “Energy-balance” studies are aimed at reducing calories from high-energy sources and increasing physical activity (PA) levels, while “shared risk factors for obesity and eating disorders” focus on reducing disordered eating behaviors to promote a positive food and eating relationship. A systematic search of ProQuest, PubMed, PsycInfo, SciELO, and Web of Science identified 8825 articles. Thirty-five studies were included in the review, of which 20 regarded “energy-balance” and 15 “shared risk factors for obesity and eating disorders”. “Energy-balance” studies were unable to support maintenance weight status, diet, and PA. “Shared risk factors for obesity and eating disorders” programs also did not result in significant differences in weight status over time. However, the majority of “shared risk factors for obesity and eating disorders” studies demonstrated reduced body dissatisfaction, dieting, and weight-control behaviors. Research is needed to examine how a shared risk factor approach can address both obesity and eating disorders.

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Section: Resultsmentioning

confidence: 99%

Impact of Strategies for Preventing Obesity and Risk Factors for Eating Disorders among Adolescents: A Systematic Review

et al. 2020

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“…Upon evaluation of titles and abstracts, 1157 articles were excluded due to their irrelevance for the research question and the remaining 52 articles were retrieved in full text for further examination. After a comprehensive assessment, 5 articles 30 - 34 met the criteria to be included in this systematic review. In addition, 1 study 35 met the inclusion criteria and was included based on the manual search.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 882 patients with melanoma, aged 20 to 85 years, participated in the 6 included studies. 30 - 35 There was considerable heterogeneity regarding cancer characteristics and timing of assessment, with cancer staging ranging from stage II to IV. In addition, the timing of study assessment was during treatment, 32 - 34 post-treatment, 32 , 35 and 1 to 10 years following diagnosis 30 , 31 ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“… 30 - 35 There was considerable heterogeneity regarding cancer characteristics and timing of assessment, with cancer staging ranging from stage II to IV. In addition, the timing of study assessment was during treatment, 32 - 34 post-treatment, 32 , 35 and 1 to 10 years following diagnosis 30 , 31 ( Table 1 ). A variety of treatments were reported including surgery (3 of 6, 50%), 30 , 31 , 35 immunotherapy (2 of 6, 33.3%), 32 , 33 and interferon-alpha (IFN-α) (1 of 6, 16.6%).…”

Section: Resultsmentioning

confidence: 99%

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Associations of Physical Activity and Exercise with Health-related Outcomes in Patients with Melanoma During and After Treatment: A Systematic Review

et al. 2021

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Purpose: Although exercise medicine is recommended to counter treatment-related side-effects and improve health-related outcomes of patients affected by different cancers, no specific recommendations exist for patients with melanoma. As a result, we systematically examined the current evidence regarding the effects of physical activity and exercise on objectively-measured and patient-reported outcomes among patients with melanoma. Methods: Searches were conducted in PubMed, CINAHL, EMBASE, SPORTDiscus, and Web of Science databases. This review included published data involving physical activity or exercise and objectively-measured or patient-reported outcomes of patients with cutaneous melanoma. The quality of included studies was assessed using the McMaster University Critical Appraisal Tool for Quantitative Studies. Results: Six studies including 882 patients with melanoma were included. Studies presented heterogeneity of design with 2 cross-sectional surveys, 2 retrospective analyses, and 2 non-randomized intervention trials. No statistically significant change in quality of life, fatigue, physical function, cardiorespiratory fitness, body composition, psychological distress, cognitive function, or treatment-related side-effects were attributable to physical activity or exercise. Importantly, physical activity or exercise during melanoma treatment or into survivorship did not adversely impact patients/survivors. Conclusion: In summary, physical activity or exercise did not adversely impact quality of life, objectively-measured or patient-reported outcomes in patients with melanoma. In addition, there is a paucity of quality studies examining the effects of physical activity or exercise on patients with melanoma throughout the cancer care continuum.

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“…However, few empirical evaluations of the role of exercise in combating symptoms of the cancer or side effects of treatment have included patients either with melanoma or those receiving immunotherapy. A feasibility study in patients with stage IV melanoma where exercise was prescribed as part of a broader supportive care intervention, indicated exercise was acceptable and achievable for patients receiving single agent immunotherapy 14…”

Section: Introductionmentioning

confidence: 99%

i-Move, a personalised exercise intervention for patients with advanced melanoma receiving immunotherapy: a randomised feasibility trial protocol

et al. 2020

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IntroductionThere is increasing evidence demonstrating the benefits of exercise in counteracting cancer treatment-related fatigue. Immunotherapy is an established treatment for advanced melanoma, and is associated with fatigue in a third of patients. The safety and efficacy of exercise in counteracting treatment-related fatigue in patients with advanced melanoma receiving immunotherapy are yet to be determined. This study aims to assess the safety, adherence to and acceptability of a mixed-methods parallel-group, pilot randomised controlled trial of a personalised, 12-week semi-supervised exercise programme prescribed by an exercise physiologist (iMove) in 30 patients with stage IV melanoma scheduled to commence immunotherapy: single agent ipilimumab, nivolumab or pembrolizumab, or combination ipilimumab and nivolumab. The trial will be used to provide preliminary evidence of the potential efficacy of exercise for managing fatigue.Methods and analysisThirty participants will be recruited from a specialist cancer centre between May and September, 2019. Participants will be randomised 1:1 to receive iMove, or usual care (an information booklet about exercise for people with cancer). Feasibility data comprise: eligibility; recruitment and retention rates; adherence to and acceptability of exercise consultations, personalised exercise programme and study measures; and exercise-related adverse events. Patient-reported outcome measures assess potential impact of the exercise intervention on: fatigue, role functioning, symptoms and quality of life. Follow-up will comprise five time points over 24 weeks. Physical assessments measure physical fitness and functioning.Ethics and disseminationThis study was reviewed and approved by the Peter MacCallum Cancer Centre Human Research Ethics Committee (HREC/48927/PMCC-2019). The findings from this trial will be disseminated via conference presentations and publications in peer-reviewed journals, and by engagement with clinicians, media, government and consumers. In particular, we will promote the outcomes of this work among the oncology community should this pilot indicate benefit for patients.Trial registration numberACTRN12619000952145; Pre-results.

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A supportive care intervention for people with metastatic melanoma being treated with immunotherapy: a pilot study assessing feasibility, perceived benefit, and acceptability

Cited by 31 publications

References 32 publications

Impact of Strategies for Preventing Obesity and Risk Factors for Eating Disorders among Adolescents: A Systematic Review

Impact of Strategies for Preventing Obesity and Risk Factors for Eating Disorders among Adolescents: A Systematic Review

Associations of Physical Activity and Exercise with Health-related Outcomes in Patients with Melanoma During and After Treatment: A Systematic Review

i-Move, a personalised exercise intervention for patients with advanced melanoma receiving immunotherapy: a randomised feasibility trial protocol

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