A supersaturating delivery system of silibinin exhibiting high payload achieved by amorphous nano-complexation with chitosan

Nguyen, Minh-Hiep; Yu, Hong; Dong, Bingxue; Hadinoto, Kunn

doi:10.1016/j.ejps.2016.04.036

Cited by 30 publications

(14 citation statements)

References 32 publications

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“…Nguyen et al [84] developed a high-payload supersaturating delivery system by preparing SILchitosan nanoparticles from a drug-polysaccharide complexation (nanoplex). At the optimal pH and chitosan-to-SIL charge ratio, the size and zeta potential of nanoplex were, respectively, 243 nm and 21 mV, while the complexation efficiency and yield were obtained in the range 83-87% and 55-63%, respectively.…”

Section: Inclusion In Polymeric Matricesmentioning

confidence: 99%

Advanced Nanotechnologies for Enhancing the Bioavailability of Silymarin: A State of the Art

Costanzo¹,

Angelico²

2019

Preprint

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Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from the milk thistle seed, Silybum marianum, has anti-oxidant, anti-inflammatory, anti-cancer and anti-viral activities potentially useful in the treatment of several liver disorders, such as chronic liver diseases, cirrhosis and hepatocellular carcinoma. Equally promising are the effects of silymarin in protecting the brain from the inflammatory and oxidative stress effects by which metabolic syndrome contributes to neurodegenerative diseases. However, despite clinical trials have proved that silymarin is safe at high doses (>1500 mg/day) in humans, it suffers limiting factors such as low solubility in water (<50 μg/mL), low bioavailability and poor intestinal absorption. To improve its bioavailability and provide a prolonged silymarin release at the site of absorption, the use of nanotechnological strategies appears to be a promising method to potentiate the therapeutic action and promote sustained release of the active herbal extract. The purpose of this study is to review the different nanostructured systems available in literature as delivery strategies to improve the absorption and bioavailability of silymarin.

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Section: Inclusion In Polymeric Matricesmentioning

confidence: 99%

Advanced Nanotechnologies for Enhancing the Bioavailability of Silymarin: A State of the Art

Costanzo¹,

Angelico²

2019

Preprint

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“…Multi-Walled Carbon Nanotubes (MWCNTs), Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a-BNNTs) and Hexagonal Boron Nitride Nanotubes (h-BNNTs) for eliminating carcinoma, sarcoma, lymphoma, leukemia, germ cell tumor and blastoma cancer cells and tissues from human blood are a new form of nanotubes with unique characteristics such as small size, high area specific surface, a hollow tube-like structure, high mechanical strength, and considerable electrical conductivity [164][165][166][167][168][169][170][171][172][173]. Nanotubes are classified as single-walled (SWNTs) and multi-walled (MWNTs).…”

Section: Introductionmentioning

confidence: 99%

“…They can show a behavior similar to that of metals or semi-conductors depending on their diameter and characteristics. These behaviors usually originate from the development and arrangement of their Nanolayers [164][165][166][167][168][169][170][171][172][173].…”

Section: Introductionmentioning

confidence: 99%

“…Studies have evaluated the application of these nanomaterials for the removal of contaminants such as micropollutants, heavy metals, radio-nucleotides, chemical organic compounds and hazardous compounds from gas currents . Multi-Walled Carbon Nanotubes (MWCNTs), Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a-BNNTs) and Hexagonal Boron Nitride Nanotubes (h-BNNTs) can also be used in the fabrication of transistors, field emission screens, Nano-lithography and biosensors [158][159][160][161][162][163][164][165][166][167][168][169][170][171][172][173].…”

Section: Introductionmentioning

confidence: 99%

“…Multi-Walled Carbon Nanotubes (MWCNTs), Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a-BNNTs) and Hexagonal Boron Nitride Nanotubes (h-BNNTs) for eliminating carcinoma, sarcoma, lymphoma, leukemia, germ cell tumor and blastoma cancer cells and tissues from human blood have been extensively investigated as adsorbents for the preconcentration and treatment of environmental contaminants, including organic and inorganic and radio-nucleotide compounds in large volumes of human blood cancer cells and tissues [150][151][152][153][154][155][156][157][158][159][160][161][162][163][164][165][166][167][168][169]. Studies have evaluated the application of these nanomaterials for the removal of contaminants such as micropollutants, heavy metals, radio-nucleotides, chemical organic compounds and hazardous compounds from gas currents .…”

Section: Introductionmentioning

confidence: 99%

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Adsorption Isotherms and Kinetics of Multi-Walled Carbon Nanotubes (MWCNTs), Boron Nitride Nanotubes (BNNTs), Amorphous Boron Nitride Nanotubes (a-BNNTs) and Hexagonal Boron Nitride Nanotubes (h-BNNTs) for Eliminating Carcinoma, Sarcoma, Lymphoma, Leukemia, Germ Cell Tumor and Blastoma Cancer Cells and Tissues

Heidari¹

2018

Clin Med Rev Case Rep

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A Practical Guide for the Preparation of Drug Nanosuspensions for Preclinical Studies: Including In Vivo Case Studies

Sigfridsson

Skantze

et al. 2018

Methods and Principles in Medicinal Chemistry

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A supersaturating delivery system of silibinin exhibiting high payload achieved by amorphous nano-complexation with chitosan

Cited by 30 publications

References 32 publications

Advanced Nanotechnologies for Enhancing the Bioavailability of Silymarin: A State of the Art

Advanced Nanotechnologies for Enhancing the Bioavailability of Silymarin: A State of the Art

A Practical Guide for the Preparation of Drug Nanosuspensions for Preclinical Studies: Including In Vivo Case Studies

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