A Summary of the Rare Reports of Osteonecrosis of the Jaw Associated With Tumor Necrosis-α Inhibitors in the United States Food and Drug Administration's Adverse Event Reporting System Database

Wichelmann, Thomas A.; Ahdi, Hardeep S; Pandravada, Sasirekha; Ehrenpreis, Eli D.

doi:10.1016/j.joms.2023.06.015

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…TRAP staining and activity showed a significant reduction in osteoclast differentiation caused by the mmu_circ_0001066 inhibitor. These results highlight that overexpression of mmu_circ_0001066 prevented BP from suppressing the osteoclast growth of RAW264.7 cells [87][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102] (Figure 3).…”

Section: Discussionmentioning

confidence: 92%

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Caserta,

Stagno,

Gangemi

et al. 2024

IJMS

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Osteonecrosis of the jaw is the progressive loss and destruction of bone affecting the maxilla or mandible in patients treated with antiresorptive and antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves the inflammatory pathway of receptor activator of nuclear factor NF-kB ligand and the macrophage colony-stimulating factor, essential for osteoclast precursors survival and proliferation and acting through its receptor c-Fms. Evidence has shown the role of non-coding RNAs in the pathogenesis of osteonecrosis of the jaw and this finding might be useful in diagnosis since these small RNAs could be considered as biomarkers of apoptotic activity in bone. Interestingly, it has been proved that miR-29 and miR-31-5p, acting on specific targets such as CALCR and RhoA, promote programmed-cell death and consequently the necrosis of bone tissue. Specific long non-coding RNAs, instead, have been detected both at reduced levels in patients with multiple myeloma and osteonecrosis, and associated with suppression of osteoblast differentiation, with consequences in the progression of mandible lesions. Among non-coding genic material, circular RNAs have the capability to modify the expression of specific mRNAs responsible for the inhibition of bisphosphonates activity on osteoclastogenesis.

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Section: Discussionmentioning

confidence: 92%

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Caserta,

Stagno,

Gangemi

et al. 2024

IJMS

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Multiple drugs

2023

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Mandibular fracture in medication‐associated osteonecrosis following infliximab therapy: A case report

Kolodziejwski,

Rosa,

Guimarães

et al. 2024

Special Care in Dentistry

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IntroductionMedication‐associated osteonecrosis of the jaws (MRONJ) is characterized by the presence of exposed bone or an intraoral or extraoral fistula in the maxillofacial region in patients with a history of treatment with anti‐resorptive and anti‐angiogenic drugs, such as monoclonal antibodies, and without a history of radiotherapy or metastatic diseases in the area.ObjectiveThe aim of this study is to report a case of a pathological mandibular fracture in an area of MRONJ in a patient diagnosed with Crohn's disease treated with infliximab.Case reportA 53‐year‐old male patient, an active smoker for 35 years, diagnosed with Crohn's disease, undergoing intravenous administration of infliximab 300 mg for 1 year and 3 months, with no previous history of anti‐angiogenic or anti‐resorptive medication, presenting with an extraoral fistula in the submandibular region for 4 months, with painful symptoms, diagnosed as MRONJ. He was initially treated conservatively, using antimicrobial photodynamic therapy (aPDT), antibiotic therapy, and the PENTO protocol. However, the patient evolved with a pathological fracture in the mandibular parasymphysis, requiring surgical reconstruction.Final considerationsPathological fracture of the mandible is a complication of MRONJ that compromises the patient's quality of life. The management of patients with MRONJ is complex and challenging.

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A Summary of the Rare Reports of Osteonecrosis of the Jaw Associated With Tumor Necrosis-α Inhibitors in the United States Food and Drug Administration's Adverse Event Reporting System Database

Cited by 3 publications

References 24 publications

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw

Multiple drugs

Mandibular fracture in medication‐associated osteonecrosis following infliximab therapy: A case report

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