A summary of 10 years of transplant activity and outcomes from a UK centre for intestinal and multivisceral transplantation

Serum Scoring and Quantitative Magnetic Resonance Imaging in Intestinal Failure-Associated Liver Disease: A Feasibility Study

“…Once modifiable causes have been minimised, the definitive treatment for IFALD is intestinal transplantation. Isolated intestinal transplantation may reverse hepatic fibrosis [27] and UK experience indicates survival with isolated small bowel grafts is longer than that for liver-containing grafts [28,29]. Interestingly, the pathophysiology of IFALD in adults differs from the paediatric population, where steatosis with variable progression to fibrosis dominate, as opposed to predominantly cholestasis in children [25,30].…”

“…Magnetic resonance imaging (MRI) has an established role in the assessment of chronic liver diseases, but the use of quantitative MRI methods for the assessment of chronic liver disease remains largely in the research rather than clinical setting. Proton magnetic resonance spectroscopy ( 1 H-MRS) can be used for reference standard measurements of hepatic steatosis [ 68 , 71 ] and has demonstrated increased fat–water ratios in patients with IFALD [ 28 , 29 ]. Chemical shift imaging-based measurements of the liver fat fraction have reported a prevalence of steatosis of 28.6% in patients with chronic IF, but it is unclear how many of these patients had IFALD [ 72 ].…”