A sulfate polysaccharide/TNF-related apoptosis-inducing ligand (TRAIL) complex for the long-term delivery of TRAIL in poly(lactic-co-glycolic acid) (PLGA) microspheres

Abstract

From the results, we concluded that TC-loaded PLGA MSs have the potential for long-term delivery of TRAIL without side effects.

TRAIL on trial: preclinical advances in cancer therapy

“…A similar strategy has been to attach PEG at different molecular weights to make PEGylated TRAIL derivatives which demonstrate protracted anti-tumor activity compared to untagged TRAIL[25, 26]. Instead of chemically modifying TRAIL, Kim et al ., used a nanocomplex system for its long-term delivery[27]. In an in vivo xenograft tumor model these TRAIL-loaded microspheres were shown to inhibit tumor growth and displayed sustained TRAIL release over 10 days[27].…”

“…Instead of chemically modifying TRAIL, Kim et al ., used a nanocomplex system for its long-term delivery[27]. In an in vivo xenograft tumor model these TRAIL-loaded microspheres were shown to inhibit tumor growth and displayed sustained TRAIL release over 10 days[27]. These approaches have helped to improve the therapeutic efficacy of systemically delivered TRAIL.…”

Coupling tumor necrosis factor‐related apoptosis‐inducing ligand to iron oxide nanoparticles increases its apoptotic activity on HCT116 and HepG2 malignant cells: effect of magnetic core size

“…Despite its therapeutic promise, assessment of TRAIL in the clinic has, so far, been disappointing (Micheau et al, ). TRAIL short half‐life, rapid renal clearance, poor solubility, and a lack of efficient administration modes have been reported when injected alone (Wang, ), prompting its combination with carriers such as latex (Kim et al, ), liposomes (Seifert et al, ), gold NPs (Huang and Hsu, ), or carbon nanotubes (Zakaria et al, ). All these engineered TRAIL‐based derivatives display higher apoptosis activity than TRAIL alone in most tumor cell lines.…”

Targeting TRAIL in the treatment of cancer: new developments

“…Ding et al published data on a dacarbazine-coated nanoparticle conjugated anti-DR5 mAb in melanoma cells in vivo, which showed a potential of improved delivery system [71]. Kim et al developed a nano-complex system between positively charged TRAIL and negatively charged chondroitin sulfate TRAIL without other chemical modulation loaded in PLGA microspheres, and showed a successful, sustained release of TRAIL [72]. Similarly, Cho et al developed magnetic nanoparticles that can turn-on the apoptosis signaling cascade in a space/timeselective fashion.…”