A Suggested New Term and Definition to Describe the Cumulative Physiological and Functional Effects of Non-injurious Head Impacts

Lavender, Andrew; Georgieva, Julia; Takechi, Ryusuke

doi:10.3389/fneur.2022.799884

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, even exposure to mTBIs that do not result in known or suspected clinical symptoms (i.e., a “subconcussive” impact) may nonetheless result in physiological, anatomical, and neurological alterations when repetitive in nature. 53 , 54 In the next section, we postulate that even if the cranium does not fracture, variation in bone thickness to alter surface area and bone density may reduce the impact strains that result in brain injury, and that such changes may contribute to the biomechanics of mTBI.…”

Section: Calvaria Impacts Contribute To Traumatic Brain Injury Pathologymentioning

confidence: 99%

Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?

Semple

Panagiotopoulou

2023

Neurotrauma Reports

View full text Add to dashboard Cite

Mild traumatic brain injuries (TBIs), particularly when repetitive in nature, are increasingly recognized to have a range of significant negative implications for brain health. Much of the ongoing research in the field is focused on the neurological consequences of these injuries and the relationship between TBIs and long-term neurodegenerative conditions such as chronic traumatic encephalopathy and Alzheimer's disease. However, our understanding of the complex relationship between applied mechanical force at impact, brain pathophysiology, and neurological function remains incomplete. Past research has shown that mild TBIs, even below the threshold that results in cranial fracture, induce changes in cranial bone structure and morphology. These structural and physiological changes likely have implications for the transmission of mechanical force into the underlying brain parenchyma. Here, we review this evidence in the context of the current understanding of bone mechanosensitivity and the consequences of TBIs or concussions. We postulate that heterogeneity of the calvarium, including differing bone thickness attributable to past impacts, age, or individual variability, may be a modulator of outcomes after subsequent TBIs. We advocate for greater consideration of cranial responses to TBI in both experimental and computer modeling of impact biomechanics, and raise the hypothesis that calvarial bone thickness represents a novel biomarker of brain injury vulnerability post-TBI.

show abstract

Section: Calvaria Impacts Contribute To Traumatic Brain Injury Pathologymentioning

confidence: 99%

Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?

Semple

Panagiotopoulou

2023

Neurotrauma Reports

View full text Add to dashboard Cite

show abstract

“…Purposeful soccer heading is unique to soccer and a skill routinely used by players during gameplay. However, soccer heading is a mechanically induced neurophysiological disruption (MIND) that, when repeated frequently, may negatively affect a player's brain health (Lavender et al, 2022). Soccer heading frequencies are associated with microstructural alterations in brain white matter and cognitive abnormalities (Lipton et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Red blood cell omega-3 fatty acid content is negatively associated with purposeful gameplay header frequencies in collegiate women soccer players: Implications for diet and brain health

Carbuhn

D’Silva

2023

Nutr Health

View full text Add to dashboard Cite

Background: Frequent soccer heading negatively affects brain health. Omega-3 fatty acids are neuroprotective against head impacts. A biomarker of omega-3 tissue status, red blood cell (RBC) omega-3 content is reduced during soccer activity. However, whether these changes are associated with frequent heading impacts is unknown. Aim: Explore the association between soccer heading frequencies and RBC omega-3 status. Methods: A prospective cohort study in collegiate women soccer players ( n = 16). Players’ RBC omega-3 status, Omega-3 Index, and self-reported gameplay header frequencies collected during a competitive season. Results: Mean Omega-3 Index (i.e., pre/postseason) was low (3.95 ± 0.44%). Postseason Omega-3 Index negatively correlated ( r = −0.545, p = 0.029) with heading frequencies. Change in Omega-3 Index negatively correlated ( r = −0.663, p = 0.005) with average headers per game. Conclusion: RBC omega-3 status is negatively influenced by frequent soccer heading throughout a competitive season which may have concerning implications for player brain health.

show abstract

The dynamics of brain frequency bands and response to neuromodulation during cognitive testing in rugby sevens athletes throughout a sports season

Fernandes,

Moscaleski,

Fonseca

et al. 2024

Curr Psychol

View full text Add to dashboard Cite

A Suggested New Term and Definition to Describe the Cumulative Physiological and Functional Effects of Non-injurious Head Impacts

Cited by 3 publications

References 14 publications

Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?

Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?

Red blood cell omega-3 fatty acid content is negatively associated with purposeful gameplay header frequencies in collegiate women soccer players: Implications for diet and brain health

The dynamics of brain frequency bands and response to neuromodulation during cognitive testing in rugby sevens athletes throughout a sports season

Contact Info

Product

Resources

About