A successful treatment strategy for clozapine-induced parotid swelling: a clinical case and systematic review

Immadisetty, Vyasa; Agrawal, Pradeep

doi:10.1177/2045125312455187

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…Interestingly, the vast majority of parotid gland swelling cases (33/40) were reported for this drug. This is in line with published literature ( 19 ).…”

Section: Resultssupporting

confidence: 94%

Medication impact on oral health in schizophrenia

Urien,

Jauregizar,

Lertxundi

et al. 2024

Med Oral

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Background Patients with schizophrenia constitute a particularly vulnerable group for oral diseases. Among the different factors involved, we aimed to examine the evidence of how drugs could contribute to the poorer oral health of this population. Material and Methods An overview of the potential impact of medication on dental/oral health among people with schizophrenia was proposed focusing on selected literature. Results Studies show a higher dental caries and degree of periodontal diseases in this population and point to drug-induced xerostomia as an important risk factor for oral health deterioration. The risk of dry mouth depends on not only antipsychotics, but also drugs with anticholinergic activity. We hypothesize that antipsychotic induced glycaemic alterations might contribute to reduced oral health, and that the antimicrobial activity of certain antipsychotics could have an impact on oral microbiota affecting oral condition. Pharmacovigilance data show that involuntary movements are caused by typical and some atypical antipsychotics. Dry mouth is most frequently reported for quetiapine and olanzapine, while clozapine is more frequently associated with sialorrhea. Conclusions Literature clearly shows higher caries and periodontal disease in schizophrenic patients. However, overall, there is scarce literature about the potential influence of drugs in these disorders. Health professionals should be aware of this issue in order to implement adequate preventive measures in this vulnerable population. Key words: Schizophrenia, oral health, dental disease, antipsychotics, anticholinergic burden.

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“…Interestingly, the vast majority of parotid gland swelling cases (33/40) were reported for this drug. This is in line with published literature ( 19 ).…”

Section: Resultssupporting

confidence: 94%

Medication impact on oral health in schizophrenia

Urien,

Jauregizar,

Lertxundi

et al. 2024

Med Oral

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“…There are no intervention protocols for these cases, and treatment can be anticholinergic drugs with the aim of blocking muscarinic receptors, and adrenergic drugs (α2 agonists/α1 antagonists) for the suppression of sympathetic stimulation. 93 …”

Section: Resultsmentioning

confidence: 99%

Rare and very rare adverse effects of clozapine

Fazio¹,

Gaetano²,

Caroleo³

et al. 2015

NDT

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Clozapine (CLZ) is the drug of choice for the treatment of resistant schizophrenia; however, its suitable use is limited by the complex adverse effects’ profile. The best-described adverse effects in the literature are represented by agranulocytosis, myocarditis, sedation, weight gain, hypotension, and drooling; nevertheless, there are other known adverse effects that psychiatrists should readily recognize and manage. This review covers the “rare” and “very rare” known adverse effects of CLZ, which have been accurately described in literature. An extensive search on the basis of predefined criteria was made using CLZ and its combination with adverse effects as keywords in electronic databases. Data show the association between the use of CLZ and uncommon adverse effects, including ischemic colitis, paralytic ileus, hematemesis, gastroesophageal reflux disease, priapism, urinary incontinence, pityriasis rosea, intertriginous erythema, pulmonary thromboembolism, pseudo-pheochromocytoma, periorbital edema, and parotitis, which are influenced by other variables including age, early diagnosis, and previous/current pharmacological therapies. Some of these adverse effects, although unpredictable, are often manageable if promptly recognized and treated. Others are serious and potentially life-threatening. However, an adequate knowledge of the drug, clinical vigilance, and rapid intervention can drastically reduce the morbidity and mortality related to CLZ treatment.

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“…Klozapinarekin jarraituz, harekin erlazionatutako beste eragin kaltegarri interesgarri bat guruin parotiden handitzea izan da; izan ere, farmako hori da modu oso nabarmenean eragin horrekin gehien erlazionatu den farmakoa. Erreakzio hori arraroa da eta bibliografian kasu gutxi batzuk baino ez daude argitaratuta klozapinarentzat (32).…”

Section: Eztabaidaunclassified

Farmako antipsikotikoak eta aho-patologia: eragin kaltegarriak jakinarazteko Europako sistemaren bidezko analisia

Urien,

Lertxundi,

Morera Herreras

et al. 2023

Osag

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Farmako antipsikotikoak nahasmendu psikiatrikoen sintomatologia tratatzeko erabilgarriak diren talde terapeutikoa dira, besteak beste, psikosi organiko eta toxikoak, nahasmendu bipolarra, dementziarekin lotutako agresibitatea eta, jakina, eskizofrenia. Nahasmendu hauen sintomatologia kontrolatzeko nahiko eraginkorrak eta erabiliak izan arren, farmako hauek eragin kaltegarri ugari eragin ditzakete, besteak beste ahokoak. Hain zuzen ere, antipsikotikoekin tratatutako paziente eskizofrenikoengan deskribatutako aho-hortzetako osasunaren hondatzearekin lotuta egon litezke.Ikerlan honen helburua izan zen farmako antipsikotikoek aho-barrunbean eragindako eragin kaltegarriak aztertzea. Horretarako, aho-mailako erreakzio kaltegarrien jakinarazpenak bilatu ziren Europako Farmakozaintzaren datu-basean (EudraVigilance)2012-2021 tartean, eta haiekin erlazionatutako farmako antipsikotiko susmagarrien analisia egin zen.Esplorazio-analisi horretan ikusi ahal izan zen, antipsikotiko tipikoekin zein atipikoekin, eragin kaltegarri jakinarazienak xerostomia, sialorrea eta ahoko diskinesia izan zirela, nahiz eta jakinarazpen kopurua handiagoa izan antipsikotiko atipikoentzat. Tipikoen artean, haloperidola izan zen jakinarazitako ahoko patologia gehien zuen farmakoa, eta, atipikoen artean, klozapina.Kontuan hartuta xerostomia, sialorrea zein ahoko diskinesia aho-patologiarekin lotzen direla, hala nola txantxarrarekin, gaixotasun periodontalarekin eta higadurarekin, farmako antipsikotikoen segurtasun-profila gehiago ezagutzeak eskizofrenia duten pertsonen osasun fisikoa eta bizi-kalitatea hobetu ditzake.

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A successful treatment strategy for clozapine-induced parotid swelling: a clinical case and systematic review

Cited by 9 publications

References 16 publications

Medication impact on oral health in schizophrenia

Medication impact on oral health in schizophrenia

Rare and very rare adverse effects of clozapine

Farmako antipsikotikoak eta aho-patologia: eragin kaltegarriak jakinarazteko Europako sistemaren bidezko analisia

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