A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report

Uno, Shunsuke; Horiuchi, Yosuke; Uchida, Takae; Yonaha, Akiko; Miyata, Takanori; Nagano, Eiko; Kodama, Takumi; Hasegawa, Naoki

doi:10.1016/j.jiac.2018.03.013

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…A retrospective review including 91 cases of vertebral spondylitis identified 28 patients (31%) with IE (15). Although none of the five previously described cases of pyogenic spondylitis due to A. actinomycetemcomitans had an IE complication (8)(9)(10)(11)(12), bacteremia caused by a HACEK organism is highly suggestive of IE. In addition, A. actinomycetemcomitans is most commonly involved in IE compared to the rest of the HACEK group (16,17).…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous Pyogenic Spondylitis and Possible Infective Endocarditis Caused by <i>Aggregatibacter actinomycetemcomitans</i>

et al. 2021

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Aggregatibacter actinomycetemcomitans, an etiological agent associated with periodontitis, endocarditis, and other infections, has rarely been implicated in spondylitis. A 70-year-old man with aortic valve replacement presented with a 4-month history of lower back pain and was diagnosed with spondylitis. Prolonged incubation of blood cultures and a biopsy yielded A. actinomycetemcomitans. Concurrent infective endocarditis (IE) was probable considering the infectious organism and the patients' prosthetic valve. The patient was treated with ceftriaxone and recovered well. Pyogenic spondylitis with possible concurrent IE may be caused by A. actinomycetemcomitans. Extended incubation and repeated cultures should be considered if HACEK infection is suspected.

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Section: Discussionmentioning

confidence: 99%

“…First, to our knowledge, only five cases of pyogenic spondylitis caused by A. actinomycetemcomitans have been reported ( 8 - 12 ) ( Table 3 ). This limited number of reports may suggest a low frequency of infections.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Pyogenic Spondylitis and Possible Infective Endocarditis Caused by <i>Aggregatibacter actinomycetemcomitans</i>

et al. 2021

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“…This organism is usually susceptible to cephalosporins, rifampin, tetracyclines, or fluoroquinolones, and in vitro susceptibility to penicillin and ampicillin is variable. However, the clinical efficacy of fluoroquinolone therapy for this organism cannot be generalized based on this report, but it should be considered if no other options are available [36].…”

Section: Treatment Of Osteomyelitis Caused By Less Common Organismsmentioning

confidence: 98%

“…Gram-positive anaerobes Levofloxacin [20,21,[26][27][28]36,37] 750 mg daily 500 mg daily 500 mg q12 h Renal adjustment…”

Section: Staph Aureus (In Combination With Rifampin)mentioning

confidence: 99%

A Review of the Clinical Utilization of Oral Antibacterial Therapy in the Treatment of Bone Infections in Adults

Haddad,

Ajaz,

Mansour

et al. 2023

Antibiotics

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Chronic osteomyelitis in adults is managed with prolonged courses of intravenous antibiotics in conjunction with surgical debridement of necrotic bone. Over the past 40 years, there has been no paradigm shift in this approach, as randomized controlled trials of this standard of care compared to alternatives such as prolonged oral antibiotics are scarce. However, there have been many small trials, case reports, and review papers evaluating the effectiveness of oral treatment for chronic osteomyelitis. The oral route for infections requiring prolonged treatment is intuitively and practically more favorable due to several advantages, the most important of which is the avoidance of long-term IV antimicrobial therapy with its complications, inconvenience, and cost. In this paper, we review the literature evaluating oral antibiotic therapy in the management of chronic bone infections since 1975. The majority of osteomyelitis infections are caused by Staphylococcus aureus, hence we focus on its treatment using oral antibiotics; however, we also emphasize subpopulations of patients with diabetes, implanted hardware, and with less common bacterial organisms. The primary objective of this review is to promulgate clinical recommendations on the use of oral antibiotics in bone infections in the context of initial therapy, transition from intravenous therapy, and the role of chronic suppression. The secondary objective is to summarize current knowledge of the specific oral antimicrobial agents that are commonly utilized, together with a synopsis of the available literature pertaining to their pharmacokinetic/pharmacodynamic properties and duration of therapy in bone infection.

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“…В процессе работы очень важно учитывать характеристики материалов, из которых будут изготавливаться будущие конструкции. Непереносимость может быть вызвана различными причинами: гальванизмом, аллергическими реакциями на стоматологические материалы, токсическими повреждениями слизистой оболочки полости рта [83].…”

Section: Clinical Medicineunclassified

Modern view on integrated treatment of patients with chronic localized periodontitis of medium severity (a literature review)

Синев

Игоревич²,

Nesterov

et al. 2020

Aspirantskiy Vestnik Povolzhiya

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A successful antimicrobial therapeutic strategy for the discitis caused by Aggregatibacter actinomycetemcomitans under unknown drug susceptibility: A case report

Cited by 3 publications

References 11 publications

Spontaneous Pyogenic Spondylitis and Possible Infective Endocarditis Caused by <i>Aggregatibacter actinomycetemcomitans</i>

Spontaneous Pyogenic Spondylitis and Possible Infective Endocarditis Caused by <i>Aggregatibacter actinomycetemcomitans</i>

A Review of the Clinical Utilization of Oral Antibacterial Therapy in the Treatment of Bone Infections in Adults

Modern view on integrated treatment of patients with chronic localized periodontitis of medium severity (a literature review)

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