A success targeted nano delivery to lung cancer cells with multi-walled carbon nanotubes conjugated to bromocriptine

Kamazani, Fatemeh M.; Nematalahi, Fattah Sotoodehnejad; Siadat, Seyed Davar; Pornour, Majid; Sheikhpour, Mojgan

doi:10.1038/s41598-021-03031-2

Cited by 21 publications

(10 citation statements)

References 49 publications

(56 reference statements)

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“… 64 Future investigations of nanotechnology-based CS formulations in our experimental systems of macrophage polarization and LM biosynthesis might reveal if cytotoxicity and SPM-impairing effects may be circumvented. Indeed, drug delivery by nanofluids improved the efficacy of isoniazid 65 or of bromocriptine, 66 and encapsulation of a cytotoxic indirubin derivative into polymer-based nanoparticles reduced its detrimental impact on monocyte viability. 67 …”

Section: Discussionmentioning

confidence: 99%

Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization

Zhang¹,

Jordan²,

Hofstetter³

et al. 2022

JIR

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Background and Purpose Celastrol (CS) is a major active ingredient of the Chinese/Asian herb Tripterygium wilfordii that is frequently used as phytomedicine to treat inflammation and autoimmune diseases. We showed before that short-term exposure to CS (1 µM) favorably impacts the biosynthesis of inflammation-related lipid mediators (LM) in human polarized macrophages by modulating the activities of different lipoxygenases (LOXs). However, whether CS regulates the expression of LOXs and other related LM-biosynthetic enzymes during macrophage polarization is unknown. Here, we investigated how CS affects LM-biosynthetic enzyme expression on the protein level and studied concomitant LM signature profiles during polarization of human monocyte-derived macrophages (MDM) towards M1- and M2-like phenotypes. Methods and Results We used LM metabololipidomics to study the long-term effects of CS on LM profile signatures after manipulation of human monocyte-derived macrophages (MDM) during polarization. Exposure of MDM to low concentrations of CS (ie, 0.2 µM) during polarization to an inflammatory M1 phenotype potently suppressed the formation of pro-inflammatory cyclooxygenase (COX)- and 5-LOX-derived LM, especially prostaglandin (PG)E 2 . Notably, gene and enzyme expression of COX-2 and microsomal PGE 2 synthase (mPGES)-1 as well as M1 markers were strongly decreased by CS during M1-MDM polarization, along with impaired activation of nuclear factor-κB and p38 mitogen-activated protein kinase. During IL-4-induced M2 polarization, CS decreased the capacity of the resulting M2-MDM to generate pro-inflammatory COX and 5-LOX products as well but it also reduced the formation of 12/15-LOX products and specialized pro-resolving mediators, without affecting the levels of liberated fatty acid substrates. Conclusion Depending on the timing and concentration, CS not only favorably affects LOX activities in macrophages but also the expression of LM-biosynthetic enzymes during macrophage polarization connected to changes of inflammation-related LM which might be of relevance for potential application of CS to treat inflammatory disorders.

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Section: Discussionmentioning

confidence: 99%

Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization

Zhang¹,

Jordan²,

Hofstetter³

et al. 2022

JIR

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“…Protein expression studies revealed that the proapoptotic protein Bax was upregulated, whereas the antiapoptotic protein Bcl-2 was downregulated in CNT-treated A549 cells compared with MRC5 cells treated with CNTs. 25 Similarly, MWCNTs functionalized with naringenin possessed an average diameter of 9.6 ± 1.4 nm and released naringenin effectively at pH 7.4 (83.5%) compared with pH 5.5 (60.8%) after 9 h compared with relatively smaller durations. The naringenin-functionalized CNTs presented limited cytotoxic effects on normal hFB fibroblasts compared with A549 cells.…”

Section: Cytotoxic Effects Of Drug-loaded Cnts On Nsclc Cells In Vitromentioning

confidence: 93%

“… 1. Bromocriptine Diameter of 25 to 40 nm, lengths ~ 500 nm A549, 49.20 μg/mL Upregulation of dopamine receptors DRD2 and DRD4, pro-apoptotic Bax and downregulation of anti-apoptotic Bcl-2 [ 25 ] 2. Naringenin Diameter of 9.6 ± 1.4 nm A549, 82.6 ± 7.3 µg/mL - [ 26 ] 3.…”

Section: Cytotoxic Effects Of Drug-loaded Cnts On Nsclc Cells In Vitromentioning

confidence: 99%

Carbon Nanotubes as Carriers in Drug Delivery for Non-Small Cell Lung Cancer, Mechanistic Analysis of Their Carcinogenic Potential, Safety Profiling and Identification of Biomarkers

Pu¹,

Wei²,

Sun³

et al. 2022

IJN

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Non-small cell lung cancer (NSCLC) is a global burden leading to millions of deaths worldwide every year. Nanomedicine refers to the use of materials at the nanoscale for drug delivery and subsequent therapeutic approaches in cancer. Carbon nanotubes (CNTs) are widely used as nanocarriers for therapeutic molecules such as plasmids, siRNAs, antisense agents, aptamers and molecules related to the immunotherapy for several cancers. They are usually functionalized and loaded with standard drug molecules to improve their therapeutic efficiency. Functionalization and drug loading possibly decrease the genotoxic and carcinogenic potential of CNTs. In addition, the targeted cytotoxic properties of the drug improve and undesired toxicity decreases after drug loading and/or conjugation with proteins, including antibodies. For intended drug delivery, a lysosomal pH of 5.5 is more suitable and effective for the slow and extended release of cytotoxic drugs than a physiological of pH 7.4. Remarkably, CNTs possess intrinsic antitumor properties and are usually internalized by endocytosis. After being internalized, several mechanisms are involved in the therapeutic and carcinogenic effects of CNTs. They are generally safe for therapy, and their toxicity profile remains dependent on their physicochemical properties. Moreover, the dose, route, duration of exposure, surface properties and degradative potential determine the toxicity outcomes of CNTs locally or systemically. In summary, the use of CNTs in drug delivery and NSCLC therapy, as well as their genotoxic and carcinogenic potential and the possible mechanisms, has been discussed in this review. The therapeutic index is generally high for NSCLC cells treated with drug-loaded CNTs; therefore, they are effective carriers in implementing targeted therapy for NSCLC.

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“…Lung cancer is one of the most prevalent cancers and the leading cause of death worldwide. n this study, a specific agonist of DRDs, BRC was delivered to lung cancer cells with MWCNTs and showed a significant anti-proliferative effect on cancer cells and low toxicity on normal lung cells [18]. Furthermore, one of these fundamental variables is the blood glucose level of a diabetic person.…”

Section: -Application Of Carbon Nanotubes In Medicine Filedmentioning

confidence: 95%

Modeling of carbon nanotubes (CNTs) and usage in drug delivery

Esfanjani

Guyo²

2022

biochemmed

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One goal of device science is miniaturization; hence nanotechnology has received Considerable attention. The possibility that the unique properties of nanostructures will result in novel applications and devices is an enticing goal. Carbon nanotubes are allotropes of carbon with a cylindrical nanostructure. Nanotubes have been constructed with a length-to-diameter ratio of up to 28,000,000:1. Potential applications for carbon nanotubes (CNTs) include their use in atomic force microscopy and in adhesives, certainly chemical or mathematical investigation of nanotubes is very important but investigates both of them together has vital notability. there is considerable open literature related to the mathematical modeling of nanotubes, also many authors have investigated the chemical aspects of nanotubes. At the present, in this review, my aim is to both mathematical and chemical aspects of structured, characteristics are investigated.

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A success targeted nano delivery to lung cancer cells with multi-walled carbon nanotubes conjugated to bromocriptine

Cited by 21 publications

References 49 publications

Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization

Modulation of Inflammation-Related Lipid Mediator Pathways by Celastrol During Human Macrophage Polarization

Carbon Nanotubes as Carriers in Drug Delivery for Non-Small Cell Lung Cancer, Mechanistic Analysis of Their Carcinogenic Potential, Safety Profiling and Identification of Biomarkers

Modeling of carbon nanotubes (CNTs) and usage in drug delivery

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