A subset of so‐called dermal non‐neural granular cell tumours are underlined by <i><scp>ALK</scp></i> fusions, further supporting the idea that they represent a variant of epithelioid fibrous histiocytoma

Perret, Raul; Jullié, Marie‐Laure; Vergier, Béatrice; Coindre, Jean‐Michel; Loarer, François Le

doi:10.1111/his.13645

Cited by 17 publications

(25 citation statements)

References 6 publications

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“…Our case represents a difficult diagnosis because the tumor mass is made up of more than 85% of granular cells. Morphology of lesions could be a great help in differential diagnosis involving comparisons with the benign granular cell tumor (GCT), which differs from granular cell dermatofibroma (GCDF) by the different histogenesis: in fact, an immunohistochemical study with antibodies against the S-100 protein is strongly and diffusely positive in benign granular cell tumor, but negative in GCDF, just as CD68 will be positive in GCDF and almost totally negative in GCT [7,8].…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Dermatofibroma: When Morphology Still Matters

et al. 2021

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Dermatofibroma, also known as “fibrous histiocytoma”, is one of the most common cutaneous soft-tissue tumors. Many variants of dermatofibromas have been described, and knowledge of these variations is important to avoid misdiagnosis of a possibly more aggressive tumor. Histological features of different variants can coexist in the same lesion, but typical common fibrous histiocytoma features are generally found, at least focally, in all cases. However, when cellular changes make up the majority of the lesion, the histopathological diagnosis can become more complex and requires immunohistochemical investigations for correct nosographic classification. We present the case of a cutaneous fibrous histiocytoma, “granular cell” variant, found on the left leg of a 74-year-old woman.

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Section: Discussionmentioning

confidence: 99%

Granular Cell Dermatofibroma: When Morphology Still Matters

et al. 2021

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“…4 T A B L E 2 Immunohistochemical studies performed Epithelioid cell histiocytoma (ECH) may also show granular cell changes, and its resemblance to the exophytic variant of NNGCT has been reported previously. 12,13 It has been suggested that ECH with granular cell change and NNGCT are one and the same neoplasm, 14 particularly in light of a recent description of ALK overexpression in both tumors. Atypical nuclear changes such as those described in some cases of NNGCT are not present in granular cell ECH.…”

Section: Discussionmentioning

confidence: 99%

“…Positivity for ALK 14 has been recently demonstrated in almost half of cutaneous NNGCT cases; this finding is correlated with underlying ALK gene fusions studied by next‐generation sequencing 28 . However, no phenotypical or behavioral differences were noted between ALK‐positive and ‐negative NNGCTs.…”

Section: Discussionmentioning

confidence: 99%

“…It was recently described that cyclin D1 plays a role in differentiating neoplastic from reactive Langerhans cell proliferation, as this protein is frequently expressed in the neoplastic cells of Langerhans cell histiocytosis. 27Positivity for ALK14 has been recently demonstrated in almost half of cutaneous NNGCT cases; this finding is correlated with underlying ALK gene fusions studied by next-generation sequencing 28. However, no phenotypical or behavioral differences were noted between ALK-positive and -negative NNGCTs.…”

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confidence: 98%

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Three additional cases of non‐neural granular cell tumor with novel immunohistochemical findings

et al. 2020

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Background: Non-neural granular cell tumor (NNGCT) is an uncommon neoplasm of controversial histogenesis and its histopathologic differential diagnosis includes, in addition to conventional GCT, other dermal tumors that may exhibit granular cell change. Methods: Three patients with a diagnosis of NNGCT were identified in the authors' files. Hematoxylin and eosin-stained sections and immunohistochemical studies were performed. Results: Histopathological study of the three lesions showed dermal proliferation of granular cells arranged in thick fascicles between collagen bundles. The lesions showed positivity for Factor XIIIa, CD163, CD68, NKIC3, vimentin, ALK, fascin, and cyclin D1. Conclusion: To our knowledge, positivity for cyclin D1 has not been reported to date in NNGCT. In borderline cases, where the diagnosis is unclear despite histopathologic and immunohistochemical findings, positivity for cyclin D1 may favor the diagnosis of NNGCT. Further investigations to assess the differentiation of this rare neoplasm are needed.

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“…It has been hypothesized that NNGCT are granular cell dermal root sheath fibromas, 2 being related to the hair follicle, or they are epithelioid variant of fibrous histiocytoma, that are often ALK rearranged 3 . In our daily practice, we occasionally come across ALK‐positive epithelioid fibrous histiocytomas (Figure 2A,B) but in our opinion they mostly maintain typical histopathological features of histiocytomas (Figure 2E,F), that is, cells are epithelioid but cytoplasm is neither so large nor so granular as NNGTC, and overall they do not evoke granular cell tumors, apart from ALK reactivity (Figure 2C,D).…”

Section: Figurementioning

confidence: 99%