A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene

Houtani, Takeshi; Ikeda, Michiko; Kase, Masahiko; Sato, Kazuo; Sakuma, Satoru; Kakimoto, Shingo; Ueyama, Teizo; Munemoto, Yumi; Takeshima, Hiroshi; Sugimoto, Tetsuo

doi:10.1016/s0304-3940(02)01186-2

Cited by 2 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…N/OFQ ( 24 ) expression have been mapped in the rat brain by in situ hybridization. NOPR mRNA expression has been mapped in the rat brain by immunohistochemistry ( 44 ) and in situ hybridization ( 21 ) and in the mouse brain by histochemical staining for NOPR-LacZ ( 23 , 29 , 45 ). Both mRNAs are expressed throughout the brain, which presents a challenge to determine the neural circuitry that underlies the effects on sleep/wake and physiological systems described here.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity

Morairty

Sun

Toll

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Sleep/wake control involves several neurotransmitter and neuromodulatory systems yet the coordination of the behavioral and physiological processes underlying sleep is incompletely understood. Previous studies have suggested that activation of the Nociceptin/orphanin FQ (N/OFQ) receptor (NOPR) reduces locomotor activity and produces a sedation-like effect in rodents. In the present study, we systematically evaluated the efficacy of two NOPR agonists, Ro64-6198 and SR16835, on sleep/wake in rats, mice, and Cynomolgus macaques. We found a profound, dose-related increase in non-Rapid Eye Movement (NREM) sleep and electroencephalogram (EEG) slow wave activity (SWA) and suppression of Rapid Eye Movement sleep (REM) sleep in all three species. At the highest dose tested in rats, the increase in NREM sleep and EEG SWA was accompanied by a prolonged inhibition of REM sleep, hypothermia, and reduced locomotor activity. However, even at the highest dose tested, rats were immediately arousable upon sensory stimulation, suggesting sleep rather than an anesthetic state. NOPR agonism also resulted in increased expression of c-Fos in the anterodorsal preoptic and parastrial nuclei, two GABAergic nuclei that are highly interconnected with brain regions involved in physiological regulation. These results suggest that the N/OFQ–NOPR system may have a previously unrecognized role in sleep/wake control and potential promise as a therapeutic target for the treatment of insomnia.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Both the N/OFQ peptide ( 21 – 23 ) and the NOPR ( 24 – 27 ) occur in hypothalamic and brainstem regions known to be involved in sleep/wake control. Among these brain regions, the N/OFQ peptide has been found in the suprachiasmatic nuclei (SCN) ( 28 ), although little to no N/OFQ mRNA is expressed there ( 21 , 28 ).…”

mentioning

confidence: 99%

Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity

Morairty

Sun

Toll

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

Lack of nociceptin receptor alters body temperature during resting period in mice

Uezu

Séi²,

Sano³

et al. 2004

NeuroReport

View full text Add to dashboard Cite

The role of nociceptin (NOC) receptor on body core temperature (Tcore) control was examined using NOC receptor knockout mice. In homozygote NOC receptor-knockout, wild-type, and control C57BL/6J and 129/SV mice, Tcore was continuously recorded under 12:12 h light:dark (LD) and conditions of constant darkness (DD). The Tcore values during the resting period were higher in the NOC receptor-knockout mice than in both wild-type and control mice under both LD and DD conditions. Spontaneous activity during the resting period and plasma cortisol levels were not different between the NOC receptor-knockout and control mice. The findings herein indicate that the NOC receptor is involved in the control of Tcore during the resting period and is independent of light, physical activity and/or cortisol regulation.

show abstract

A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene

Cited by 2 publications

References 10 publications

Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity

Activation of the nociceptin/orphanin-FQ receptor promotes NREM sleep and EEG slow wave activity

Lack of nociceptin receptor alters body temperature during resting period in mice

Contact Info

Product

Resources

About