A subset of brain neurons controls regurgitation in adult <i>Drosophila melanogaster</i>

Chen, Yu-Chieh; Ahmad, Sameera; Amin, Kush; Dahanukar, Anupama

doi:10.1242/jeb.210724

Cited by 5 publications

(4 citation statements)

References 79 publications

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“…Tracing experiments reveals that both appetitive and aversive pharyngeal GRNs convey inputs to two common brain areas (pars intercerebralis and lateral protocerebrum), suggesting that pharyngeal taste is represented across brain regions. This study demonstrates an important role of pharyngeal taste in controlling food choice and intake [105].…”

Section: Bitter Taste Circuit In the Brainmentioning

confidence: 64%

“…In another genetic screen to understand how sensory information is translated into behavior, a subset of higher order neurons labeled by VT041723-GAL4 transgenic line are identified that controls regurgitation after food ingestion [105]. The neurons labeled by VT041723-GAL4 receive sensory input from peripheral Ir76b+ taste neurons in the pharynx.…”

Section: Central Neurons Controlling Regurgitationmentioning

confidence: 99%

“…However, motor circuits controlling regurgitation and if PER and regurgitation share common motor programs are not known. Identification of VT041723-GAL4 neurons provide a ground to address such questions [105].…”

Section: Central Neurons Controlling Regurgitationmentioning

confidence: 99%

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Drosophila Central Taste Circuits in Health and Obesity

Kaushik¹,

Rawat²,

Kain³

2021

Role of Obesity in Human Health and Disease

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When there is a perturbation in the balance between hunger and satiety, food intake gets mis-regulated leading to excessive or insufficient eating. In humans, abnormal nutrient consumption causes metabolic conditions like obesity, diabetes, and eating disorders affecting overall health. Despite this burden on society, we currently lack enough knowledge about the neuronal circuits that regulate appetite and taste perception. How specific taste neuronal circuits influence feeding behaviours is still an under explored area in neurobiology. The taste information present at the periphery must be processed by the central circuits for the final behavioural output. Identification and understanding of central neural circuitry regulating taste behaviour and its modulation by physiological changes with regard to internal state is required to understand the neural basis of taste preference. Simple invertebrate model organisms like Drosophila melanogaster can sense the same taste stimuli as mammals. Availability of powerful molecular and genetic tool kit and well characterized peripheral gustatory system with a vast array of behavioural, calcium imaging, molecular and electrophysiological approaches make Drosophila an attractive system to investigate and understand taste wiring and processing in the brain. By exploiting the gustatory system of the flies, this chapter will shed light on the current understanding of central neural taste structures that influence feeding choices. The compiled information would help us better understand how central taste neurons convey taste information to higher brain centers and guide feeding behaviours like acceptance or rejection of food to better combat disease state caused by abnormal consumption of food.

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Section: Bitter Taste Circuit In the Brainmentioning

confidence: 64%

Section: Central Neurons Controlling Regurgitationmentioning

confidence: 99%

See 1 more Smart Citation

Drosophila Central Taste Circuits in Health and Obesity

Kaushik¹,

Rawat²,

Kain³

2021

Role of Obesity in Human Health and Disease

View full text Add to dashboard Cite

show abstract

“…Возможно, что мутации возникли в генах, контролирующих хемосенсорный ответ, которые вызывают или усиливают аверсивный (не связанный с кормлением) ответ на имидаклоприд в поведенчески устойчивых линиях мух. Работы по изучению аверсии к сахарам D. melanogaster и рыжего таракана Blattella germanica показали, что генетические мутации могут приводить к изменениям хеморецепторов, что приводит к изменению поведения насекомых, включая отвращение к пище и подавление её потребления (Wada-Katsumata et al, 2014, French et al, 2015., Chen et al 2019. Показано, что аверсия к имидаклоприду у комнатной мухи также находится под генетическим контролем (Hubbard, Gerry, 2021).…”

Section: механизмы резистентностиunclassified