A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements

Fornal, Casimir A.; Metzler, Christine W.; Marrosu, F; Ribeiro-do-Valle, L.E.; Jacobs, Barry L.

doi:10.1016/0006-8993(96)00006-6

Cited by 142 publications

(72 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent with this idea, the satiety response after food intake includes facial grooming, which can also be elicited by stimulation of 5-HT 1B and 5-HT 1C receptors (Kitchener and Dourish, 1994). In addition, a subset of dorsal raphe serotonergic neurons has been reported to increase activity during oral-buccal movements, including chewing, licking, and grooming (Fornal et al, 1996). This suggests that 5-HT release may increase in specific terminal regions during these behaviors.…”

Section: Discussionmentioning

confidence: 99%

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

et al. 1997

View full text Add to dashboard Cite

Serotonin (5-HT) is generally inhibitory to masculine sexual behavior. It has been suggested that 5-HT released after ejaculation may promote the sexual quiescence of the postejaculatory interval (PEI). The following experiments were conducted to test (1) whether extracellular 5-HT increases in either the anterior lateral hypothalamic area (LHA A ) or the medial preoptic area (MPOA) of male rats after ejaculation; (2) whether increasing 5-HT in these sites, by microinjecting the selective serotonin reuptake inhibitor alaproclate, could inhibit copulatory abilities; and (3) whether copulation deficits produced by alaproclate were attributable to locomotor impairments. The effects of local application of alaproclate on extracellular 5-HT levels in the LHA A and the MPOA were also tested. Extracellular serotonin was measured in all experiments using in vivo microdialysis.Ejaculation was correlated with enhanced 5-HT release from the LHA A ; no 5-HT increases were observed before ejaculation, and levels were decreased toward basal values during a subsequent copulatory series. Elevating 5-HT in the LHA A by microinjecting alaproclate inhibited copulation by increasing the latency to mount, intromit, and ejaculate. This inhibition did not result from nonspecific locomotor impairments. In the MPOA, 5-HT release remained stable throughout copulation, and microinjecting alaproclate into this site did not significantly alter sexual behavior.These data support the large body of evidence suggesting that 5-HT is inhibitory to masculine sexual behavior. Furthermore, the LHA A , but not the MPOA, may be one site responsible for serotonergic inhibition of copulation during the PEI.

show abstract

Section: Discussionmentioning

confidence: 99%

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

et al. 1997

View full text Add to dashboard Cite

show abstract

“…S2C, available at www.jneurosci.org as supplemental material). Some reward consumption activity may be related to rhythmic oral-buccal movements, such as licking and chewing (Fornal et al, 1996).…”

Section: -Ht Neurons In Reward and Non-reward Delaysmentioning

confidence: 99%

“…Previous recording studies of the dorsal raphe nucleus (DRN), a center of forebrain 5-HT projection (Jacobs and Azmitia, 1992), revealed activation of putative 5-HT neurons correlated to the level of behavioral arousal (Jacobs and Fornal, 1999), salient sensory stimuli (Heym et al, 1982;Waterhouse et al, 2004;Ranade and Mainen, 2009), and rhythmic motor outputs (Fornal et al, 1996). Recent recording studies in monkey (Nakamura et al, 2008) and rat (Ranade and Mainen, 2009) demonstrated that DRN neurons display firing correlated with diverse behavioral events, including rewards and conditioned cues, but no study has established a link between 5-HT neuron activity in the DRN and impulsive behaviors.…”

Section: Introductionmentioning

confidence: 99%

Activation of Dorsal Raphe Serotonin Neurons Underlies Waiting for Delayed Rewards

Miyazaki¹,

Doya²

2011

J. Neurosci.

207

167

View full text Add to dashboard Cite

The serotonergic system plays a key role in the control of impulsive behaviors. Forebrain serotonin depletion leads to premature actions and steepens discounting of delayed rewards. However, there has been no direct evidence for serotonin neuron activity in relation to actions for delayed rewards. Here we show that serotonin neurons increase their tonic firing while rats wait for food and water rewards and conditioned reinforcement tones. The rate of tonic firing during the delay period was significantly higher for rewards than for tones, for which rats could not wait as long. When the delay was extended, tonic firing persisted until reward or tone delivery. When rats gave up waiting because of extended delay or reward omission, serotonin neuron firing dropped preceding the exit from reward sites. Serotonin neurons did not show significant response when an expected reward was omitted, which was predicted by the theory that serotonin signals negative reward prediction errors. These results suggest that increased serotonin neuron firing facilitates a rat's waiting behavior in prospect of forthcoming rewards and that higher serotonin activation enables longer waiting.

show abstract

“…The firing activity of putative serotonergic DRN neurons in behaving cats increases across the sleep-wake-arousal cycle (Trulson and Jacobs, 1979;Sakai and Crochet, 2001) and reflects the level of ongoing motor activity (Trulson et al, 1981;Steinfels et al, 1983). Further, at least certain subpopulations of putative serotonergic DRN neurons are excited by the presentation of auditory and visual stimuli (Heym et al, 1982;Shima et al, 1986), and during rhythmic oral-buccal movements and in response to tactile stimulation (Fornal et al, 1996). Although extensive electrophysiological work has been devoted to examining the firing properties of putative serotonergic DRN neurons in behaving animals (Trulson and Jacobs, 1979;Trulson et al, 1981;Heym et al, 1982;Steinfels et al, 1983;Fornal et al, 1996;Veasey et al, 1997; GuzmanMarin et al, 2000;Sakai and Crochet, 2001), much less is known about the response properties of nonserotonergic DRN neurons.…”

mentioning

confidence: 99%

“…Further, at least certain subpopulations of putative serotonergic DRN neurons are excited by the presentation of auditory and visual stimuli (Heym et al, 1982;Shima et al, 1986), and during rhythmic oral-buccal movements and in response to tactile stimulation (Fornal et al, 1996). Although extensive electrophysiological work has been devoted to examining the firing properties of putative serotonergic DRN neurons in behaving animals (Trulson and Jacobs, 1979;Trulson et al, 1981;Heym et al, 1982;Steinfels et al, 1983;Fornal et al, 1996;Veasey et al, 1997; GuzmanMarin et al, 2000;Sakai and Crochet, 2001), much less is known about the response properties of nonserotonergic DRN neurons. Experiments in chloral hydrate-anesthetized rats have demonstrated that stimulation of the sciatic nerve suppresses the firing of putative serotonergic DRN cells but increases the firing of putative nonserotonergic cells (Aghajanian et al, 1978).…”

mentioning

confidence: 99%

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Halberstadt

Balaban

2008

Journal of Chemical Neuroanatomy

View full text Add to dashboard Cite

The dorsal raphe nucleus (DRN) contains both serotonergic and non-serotonergic projection neurons. Retrograde tracing studies have demonstrated that components of the basal forebrain and extended amygdala are targeted heavily by input from nonserotonergic DRN neurons. The object of this investigation was to examine the terminal distribution of nonserotonergic DRN projections in the basal forebrain and extended amygdala, using a technique that allows selective anterograde tracing of nonserotonergic DRN projections. To trace nonserotonergic DRN projections, animals were pretreated with nomifensine, desipramine and the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), 7 days prior to placing an iontophoretic injection of biotinylated dextran amine (BDA) into the DRN. In animals treated with 5,7-DHT, numerous nonserotonergic BDA-labeled fibers ascended to the basal forebrain in the medial forebrain bundle system. Some of these labeled fibers crossed through the lateral hypothalamus, bed nucleus of the stria terminalis, and substantial innominata. These fibers entered the amygdala through the ansa peduncularis and ramified within the central and basolateral amygdaloid nuclei. Other fibers entered the diagonal band of Broca and formed a dense plexus of labeled fibers in the dorsal half of the intermediate portion of the lateral septal nucleus and the septohippocampal nucleus. These findings demonstrate that the basal forebrain and extended amygdala receive a dense projection from nonserotonergic DRN neurons. Given that the basal forebrain plays a critical role in processes such as motivation, affect, and behavioral control, these findings support the hypothesis that nonserotonergic DRN projections may exert substantial modulatory control over emotional and motivational functions. Keywords amygdala; bed nucleus; 5,7-dihydroxytryptamine; septal nuclei; biotinylated dextran amine; tyrosine hydroxylase It is well known that the dorsal raphe nucleus contains more than half of all the serotonergic neurons in the brain (Leger and Wiklund, 1982) and is a source of projections that terminate extensively throughout the central nervous system (Vertes, 1991;Sim and Joseph, 1993;Vertes and Kocsis, 1994;Morin and Meyer-Bernstein, 1999 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. within dorsomedial (DRNdm), ventromedial (DRNvm), and lateral (DRNl) cell groups . It has been proposed that the activity of serotonergic DRN neurons plays an important role in the coordination of sensory processing and motor output with the sleep-wake-arousal cycle (Jacobs and Azmitia, 1992; Forn...

show abstract

A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements

Cited by 142 publications

References 32 publications

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats

Activation of Dorsal Raphe Serotonin Neurons Underlies Waiting for Delayed Rewards

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Contact Info

Product

Resources

About