A Subcortical Feeding Circuit Linking Interoception to Jaw movement
Christin Kosse,
Jessica Ivanov,
Zachary Knight
et al.
Abstract:TThe brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the underlying circuitry linking inputs to outputs is unknown. Here we delineate a subcortical circuit in which brain-derived neurotrophic factor (BDNF) expressing neurons in the ventromedial hypothalamus (VMH) directly connect interoceptive inputs to motor centers controlling food consumption. VMHBDNF neuron inhibition increases food intake by gating motor sequences of feeding through projections to prem… Show more
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