A subacute treatment of L-methionine induces an increase in the number of [3H]spiperone binding sites in the striatum of the rat

Fur, G. Le; Phan, T.; Burgevin, Marie-Claude; Flamier, A.; Mitrani, N.; Marquis, F.; Jozefczak, C.; Uzan, A.

doi:10.1016/0024-3205(83)90761-0

Cited by 8 publications

(2 citation statements)

References 18 publications

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“…It is well known, that membrane viscosity regulates synaptic functions (Loh & Hitzemann, 1981). Furthermore, several receptors such as the dopamine (Le Fur et al, 1983), and 5-HT-receptors (Heron et al, 1980) (Kinnier et al, 1981;Dumbrille-Ross et al, 1983;Davis, 1984a (Davis, 1984b). Taken together, the present results suggest that imipramine binding and 5-HT transport systems share a similarly reacting protein.…”

Section: Discussionsupporting

confidence: 59%

“…It is well known, that membrane viscosity regulates synaptic functions (Loh & Hitzemann, 1981). Furthermore, several receptors such as the dopamine (Le Fur et al, 1983), and 5-HT-receptors (Heron et al, 1980) in the central nervous system are unmasked and rendered available for binding when the membrane fluidity is mildly increased. Incubations at 40C for the binding of [3HJ-imipramine, and at 370C for binding and uptake of [3H]-5-HT might have influenced membrane viscosity differently, thus rendering disulphide bonds less or more accessible to thiol reagents.…”

Section: Group Imentioning

confidence: 99%

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Selective effects of thiol reagents on the binding sites for imipramine and neurotransmitter amines in the rat brain

Biassoni

Vaccari

1985

British J Pharmacology

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IThe action of the antithyroid drugs methimazole (MMI) and propylthiouracyl (PTU) on 4 The effects ofNEM on imipramine recognition sites and on the uptake of 5-HT could be prevented by DTT; protection was not obtained in other receptor systems.5 Three groups of receptors have been, thus, postulated, based upon their different sensitivity towards alterations in membrane [disulphide bridges = SHJ equilibrium: Group I, including imipramine recognition sites and the uptake system for 5-HT; Group II, including 5-HT,-receptors; Group III, including 5-HT2-and D2-receptors.

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Section: Discussionsupporting

confidence: 59%

“…It is well known, that membrane viscosity regulates synaptic functions (Loh & Hitzemann, 1981). Furthermore, several receptors such as the dopamine (Le Fur et al, 1983), and 5-HT-receptors (Heron et al, 1980) in the central nervous system are unmasked and rendered available for binding when the membrane fluidity is mildly increased. Incubations at 40C for the binding of [3HJ-imipramine, and at 370C for binding and uptake of [3H]-5-HT might have influenced membrane viscosity differently, thus rendering disulphide bonds less or more accessible to thiol reagents.…”

Section: Group Imentioning

confidence: 99%