A sub-set of guanine- and cytosine-rich genes are actively transcribed at the nuclear Lamin B1 region
Gayan I. Balasooriya,
Tse-Luen Wee,
David L. Spector
Abstract:Chromatin organization in the mammalian cell nucleus plays a vital role in the regulation of gene expression. The lamina-associated domain at the inner nuclear membrane has been proposed to harbor heterochromatin, while the nuclear interior has been shown to contain most of the euchromatin. Here, we show that a sub-set of actively transcribing genes, marked by RNA Pol II pSer2, are associated with Lamin B1 at the inner nuclear envelop in mESCs and the number of genes proportionally increases upon in vitro diff… Show more
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