A Study to Find the Distribution of Abo Blood Group in Beta Thalassemia

Abstract

INTRODUCTION: - Beta thalassemia (ẞ-thalassemia) is an inherited hematological disorder involving decreased amount of hemoglobin production. It is a major problem of concern causing high mortality rates in children. Thalassemia patients suffer from severe anemia due to which they need to get repeated blood transfusion after a regular period of time. Many studies have reported association of ABO blood group with diseases. AIM AND OBJECTIVES: - To study the relation between the ABO blood group and beta thalassemia. MATERIALS AND METHODS: - This was a cross sectional, observational survey-based on study conducted at Dept. of Physiology, A’bad with the help of Thalassemia Care Centre, Civil Hospital, Ahmedabad. The study was conducted on 300 registered beta thalassemia major patients during February 2019 to August 2019 over a period of 6 months. These patients visited the thalassemia care center for repeated blood transfusion. Blood group of the patient was determined by Slide Agglutination Method at Department of Physiology. Results were prepared & tabulated in Microsoft Excel 2013. RESULTS: - It is found that among the study that males were more affected than females. It is more prevalent in Rh positive individuals as compared to Rh negative. Frequency of blood groups affecting patients were O>B>A>AB. CONCLUSION: - Thalassemia is more prevalent in males than females. The most commonly affected blood group is O positive followed by B positive, A positive and last AB positive. Among the Rh blood group, Rh positive were more as compared to Rh negative but Rh-negative females were more common than Rh positive males.

Association of β-Thalassemia and its Types with ABO and Rh Blood Groups in Lahore, Pakistan

“…According to Table 1, the most common blood group present in βthalassemia patients was O (34.6%), followed by B (29%), and A (25%), while the least common blood group was AB (11.4%). The ABO blood group pattern observed in the current study was O>B>A>AB, which is similar to the past studies [14][15][16][17]. It was found that Rh factor was present in most of the β-thalassemia patients (94.2%) and absent only in a few (5.8%) patients.…”