A study to evaluate the antidiabetic effect of Syzygium cumini Linn. seed extract in high fructose diet induced diabetes in Albino Rats

Abstract

Background: The objective of the study was to evaluate the antidiabetic effect of syzygium cumini linn. Seed extract in high fructose diet induced diabetes in albino rats.Methods: This study was conducted in two phases. In Phase I acute and chronic effects of three doses of Syzygium cumini Linn 200mg/kg, 400mg/kg and 800mg/kg was seen in euglycaemic rats. In Phase II, the above doses of Syzygium cumini Linn were seen in diabetes induced by high fructose diet was evaluated. 5 groups of 06 animals each. Group I was given normal saline orally. Group II, III and IV were given oral Syzygium extract in the dose of 200mg/kg, 400mg/kg and 800mg/Kg respectively. Group V was given glibenclamide suspension 10 mg/Kg orally. Blood glucose was measured before starting this phase (Day 0), at the end of fructose feeding (day 28) and weekly thereafter up to the end of the treatment period (i.e. on days 35,42,49,56).Results: In phase I of the study, Syzygium extract had no effect on the mean blood glucose levels when given in the doses of 200, 400 and 800 mg/kg, from 1-24 hours. After chronic administration to euglycemic rats for 4 weeks, Syzygium extract also did not produce any significant change in blood glucose levels when given at various doses from 200-800 mg/kg. Treatment with all the three doses of Syzygium cumini extract (200,400 and 800mg/kg) produced a significant reduction in the blood glucose level. (P value <0.001 as compared to group I). The glucose lowering effect started at the end of 1 weeks and it increased till the end of the study in all the groups.Conclusions: Syzygium cumini Linn extract has no effect on the blood glucose levels of euglycemic animals. Syzygium cumini Linn extract can reduce blood glucose levels in high fructose diet induced diabetic rats, in a dose dependent and time dependent manner.

Cypermethrin-Induced Alterations in Serum Calcium and Phosphate of Rats: Protective Role of Jamun Seed and Orange Peel Extracts

“…Dose of cypermethrin used in this study has been selected considering the doses used earlier by other investigators-(i) 40-120 mg/kg b wt (Nair et al, 2011), (ii) 30 mg/ kg b wt (Hamid et al, 2017 and (iii) 21.2-85 mg/kg b wt (Madu, 2015). The dose of jamun seed extract used in this study has been selected on the basis of doses used by earlier workers -(i) 250 mg/kg b wt (Behera et al, 2014), (ii) 200-800 mg/kg b wt (Vihan and Brashier, 2017) and (iii) 200 and 400 mg/kg b wt (Kumar and Thakur, 2018). Dose of orange peel extract used in this study has been selected considering the doses used earlier by other investigators-(i) 125, 250 and 500 mg/kg b wt (Muhtadi et al, 2015), (ii) 100, 200 and 400 mg/kg b wt (Selmi et al, 2017) and 200 mg/kg b wt (Bashandy et al, 2019).…”

Phyto-Medicinal Effects of Syzygium Cumini on Diabetes: A Review

“…Ability to check the conversion of starch into sugar in case of excess production of glucose; Glycosidases remove sugar residues; Jamboline slows down the diastatic conversion of starch into sugar. [22,24,[31][32] 7…”

“…[30] Although Syzygium cumini (seed aqueous extract) can reduce blood glucose levels in high fructose diet induced diabetic rats, in a dose dependent (200mg/kg, 400mg/kg and 800mg/kg) manner, but in euglycemic animals it had no effect on the blood glucose levels. [31] Some other research investigations about hypoglycemic effects of S. cumini has been showed in a tabular form (Table 3). According to the literature, petroleum ether soluble fraction of S. cumini seed methanolic extract @ 300 mg/kgbw (76.82%) [43] and seed ethanolic extract @ 500 mg/kgbw (69%) [37] showed the best hypoglycemic results (Table 3).…”