A study to evaluate antioxidant and hepatoprotective activity of aqueous extract of roots of Valeriana wallichii in CCl4 induced hepatotoxicity in rats

Syed, Shariq Naeem; Rizvi, Waseem; Kumar, Anil; Khan, Aijaz Ahmad; Moin, Shagufta; Ahsan, Akif

doi:10.5455/2319-2003.ijbcp20140418

Cited by 6 publications

(4 citation statements)

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“…It results in an increased level of liver marker enzymes such as ALP and ALT. The level of biochemical markers such as cholesterol, bilirubin, and triglycerides (Chen et al, 2012;Syed et al, 2014). The results of current study demonstrated that AgNPs and chicory formulation extract possessed remarkable hepato-protective potential (Table 3).…”

Section: Discussionmentioning

confidence: 68%

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Siddiqa,

Qureshi,

Raja

et al. 2024

Front. Pharmacol.

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Background: Liver disease is a serious health concern in today’s world, posing a challenge to both healthcare providers and pharmaceutical companies. Most synthetic drugs and chemicals cause liver damage accounting for approximately 10% of acute hepatitis and 50% of acute liver failure.Purpose: The present study aimed to evaluate the hepato-protective activity of an extract of chicory formulation assisted by silver nanoparticles against carbon tetra chloride (CCl4)-induced hepatic damage in rat’s liver.Methods: Rats of the Wistar strain (Rattus norvegicus) were used to test the in vivo hepato-protective efficacy at various doses. Rats were randomly divided into nine groups, each containing six rats. The groups were as follows: first group (control), second group (CCl4), third group, silymarin (20 mg/kg of body weight), fourth group (CCl4+chicory) (1.75 mg/kg of b. wt), fifth group (CCl4 + chicory at the dose of 2.35 mg/kg), sixth group (CCl4 + chicory of 3.25 mg/kg), seventh group (CCl4 +AgNPs 1.75 mg/kg of b. wt.), eighth group (CCl4 + AgNPs 2.35 mg/kg of body weight), and ninth group (CCl4 + AgNPs 3.25 mg/kg of b. wt.). Blood samples were taken 24 h after the last administration (i.e., 30th day). The blood samples were analyzed for different serum enzymes such as ALP (alkaline phosphatase), ALT (alanine transaminase), bilirubin (Blr), triglyceride, and cholesterol. Histology liver sections were performed.Results: Treatment with AgNPs and chicory extract showed significant hepato-protective activity in a dose-dependent manner. In three doses, the chicory extract at a rate of 3.25 mg/kg of body weight significantly reduced elevated levels of biochemical markers in comparison to CCl4-intoxicated rats. Histology of the liver sections from CCl4-treated rats revealed inflammation of hepatocytes, necrosis, cytoplasmic degeneration, vacuolization, and a deformed central vein. The chicory formulation extract exhibited a remarkable recovery percentage in the liver architecture that was higher than the drug (i.e., silymarin). While treatment with AgNPs also repaired the degenerative changes and restored the normal form of the liver, chicory formulation extract possessed more hepato-protective potential as compared to AgNPs by regulating biochemical and histo-pathological parameters.Conclusion: This study can be used as confirmation of the hepato-protective potential of chicory compounds for possible use in the development programs of drugs to treat liver diseases.

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Section: Discussionmentioning

confidence: 68%

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Siddiqa,

Qureshi,

Raja

et al. 2024

Front. Pharmacol.

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“…[69] Antioxidants are reducing agents which inhibit the oxidation of other molecules and can be used not only to prevent but also to treat health complications of metabolic syndrome and atherosclerosis. Experimental studies showed that piperine, [70] P. anisum Lin seeds, [71] A. graveolence Lin seeds, [72] V. wallichii, Lin rhizome [73] and A. cepa Lin bulb [44] reduce HFD-induced oxidative stress to the cells. The antioxidant activity of these drugs might be due to the polyphenolic compounds present in these drugs.…”

Section: Discussionmentioning

confidence: 99%

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2022

IJGP

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Background: Metabolic syndrome is a cluster of risk factors for CVD and diabetes. The number of individuals with metabolic syndrome continues to rise. The current study aimed to test the efficacy and safety of an Integrative Unani personalized regimen (IUPR) in reducing the risk factors of metabolic syndrome. Materials and Methods: Patients according to NCEP ATP III criteria were selected, 50 patients (30 in the test group and 20 in the control group) completed the study. The test group was treated with an IUPR and the control group was treated for respective risk factors with standard drugs for 2 months. The response was measured by changes in TC, TG, HDL, FBS, BP, WC, and Weight. Results: IUPR was found superior in reducing body weight, waist circumference, and BP (P < 0.01), equivalent in reducing serum triglyceride and fasting blood sugar level and inferior in reducing total cholesterol compared to standard drugs provided for respective risk factors after 2 months of intervention. HDL increased by 1.033 mg/dl in the test and decreased in the control group by 4.850 mg/dl. Conclusion: In metabolic syndrome lipid storage increases due to the deterrence of the pathological mechanisms. Unani regimen caused a reduction in risk factors of the metabolic syndrome might be by attenuation in physiological changes possibly by reverting rate-limiting enzymes and increasing energy expenditure. Long-term high-quality trials with dietary modification are needed to get optimal results.

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“…was given 4 on Day1 and Day 4 at 9:00 am. Standard drug used was silymarin, given in a dose of 50 mg/kg/day by oral route for a period of 14 days (Syed et al, 2014). The test drugs dissolved in distilled water were given by oral route at 1:00 pm for a period of 14 days simultaneously with CCl treatment.…”

Section: Hepatotoxicity Inductionmentioning

confidence: 99%

“…Carbon tetrachloride (CCl ) induced hepatic damage raised the 4 level of enzymes as serum AST, ALT, ALP and Total serum bilirubin and percentage of hepatoprotection against CCl 4 induced injury was calculated(Syed et al, 2014). Silymarin provided highest percentage of hepatoprotection by reducing AST, ALT, ALP and total bilirubin against CCl induced liver 4 injury.…”

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confidence: 99%

Hepatoprotective effect of aqueous extracts of root and peel of Punica granatum in wistar rats

Khan¹,

Jamal²,

Ahmad³

et al. 2018

Asian J Pharm Pharmacol

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Objective: To evaluate the hepatoprotective effect of aqueous extracts of root (RAE) and peel (PAE) of Punica granatum. This study was conducted on adult albino Wistar rats of either sex weighing 150-Materials and Methods: 200 g. Animals were divided into five groups (n=5). Liver injury was produced by carbon tetrachloride (CCl) 1 ml/kg 4 dissolved in olive oil (1:1) given intraperitoneally on day 1 and day 4 of the study duration of 14 days. Silymarin (50 mg/kg/d) orally was used as standard drug. Test groups received aqueous extract of root (RAE) at doses of P. granatum 200 and 400 mg/kg/day and aqueous extract of (PAE) peel at doses of 200 and 400 mg/kg/day orally along P. granatum with CCl. On the 15 day, the hepatoprotective effect of RAE and PAE was evaluated by assessment of physical 4 th parameters, histopathological examination and biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total serum bilirubin in blood sample. The Results: administration of RAE of at doses of 200 and 400 mg/kg/day orally, exhibited a highly significant decrease P. granatum in the rise of mean serum AST, ALT, ALP, and total bilirubin as compared to CCl treated group (p<0.001). PAE 200 4 mg/kg/day showed highly significant reduction in serum AST, ALT and serum total bilirubin (p<0.001). PAE 200mg/kg/day showed significant reduction in ALP (p<0.01). PAE 400mg/kg/day showed highly significant reduction in serum AST, ALT, ALP and total serum bilirubin when compared to CCl treated group (p<0.001). Histopathological 4 examination of the liver also suggested hepatoprotective effect of RAE and PAE of by restoration of P. granatum hepatic architecture toward normal. Maximum decrease in the extent of centrilobular necrosis was observed in RAE 400 mg/kg/day treated rats when compared to CCl treated group. This study demonstrated 4 Conclusion: hepatoprotective activity of RAE and PAE of against CCl induced liver injury in rats. P. granatum

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A study to evaluate antioxidant and hepatoprotective activity of aqueous extract of roots of Valeriana wallichii in CCl4 induced hepatotoxicity in rats

Cited by 6 publications

References 8 publications

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

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Hepatoprotective effect of aqueous extracts of root and peel of Punica granatum in wistar rats

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