A study to determine the underlying reason for abnormal glandular cytology and the formulation of a management protocol

Leeson, Simon; Inglis, T. C. M.; Salman, W D

doi:10.1046/j.1365-2303.1997.43175431.x

Cited by 12 publications

(5 citation statements)

References 5 publications

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“…However, due to its relative rarity, the management of CGIN varies from LLETZ and CKC to SH. Following the diagnosis of CGIN on a cervical smear the clinician is committed to examination of the whole of the transformation zone/endocervical canal 24 . In our study, of the 14 patients who had colposcopically directed punch biopsy, 13 went on to have either CKC or LLETZ.…”

Section: Discussionmentioning

confidence: 96%

A retrospective clinical audit of cervical smears reported as ‘glandular neoplasia’

et al. 2004

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The aims of this study were to review the diagnostic pathway of women with smears reported as 'glandular neoplasia' and to outline the management, colposcopy findings, treatment and final histological diagnosis in these women. The design was a retrospective review. A total of 114 women were identified over a 5-year period from the cytology database at the Royal Liverpool University Hospital Cytology Department, whose hospital case notes were available for review. Methods included a review of the case notes for the demographic details, indication for smear, colposcopic findings, investigation and/or treatment procedures, histology, final diagnosis and current disease status. Of 114 smears reported as 'glandular neoplasia', 67 were reported as consistent with cervical glandular intra-epithelial neoplasia (CGIN), six with endocervical adenocarcinoma, 36 with endometrial adenocarcinoma and five with other glandular neoplastic abnormalities. The average age was 46.5 years. 79 (69.3%) smears were routine call/recall and 36 (30.7%) women were symptomatic. The positive predictive value (PPV) for a significant histological abnormality in the CGIN smear group was 80.6% (23.9% invasive carcinomas, 43.3% CGIN and 13.4% CIN) and the PPV of an 'endometrial adenocarcinoma' smear was 86.1%. Smears indicating glandular neoplasia are associated with a high probability of clinically significant lesions, the PPV of a CGIN smear being over 80%. Immediate referral for colposcopy and assessment by an experienced colposcopist is recommended.

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Section: Discussionmentioning

confidence: 96%

A retrospective clinical audit of cervical smears reported as ‘glandular neoplasia’

et al. 2004

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“…Based on the NHSCSP ‘ABC’ publication 4 , the abnormal glandular cytology of this study is of borderline category and not of glandular neoplastic category, the latter representing definite glandular dyskaryosis. Leeson et al 5 found, on review of 89 women with glandular dyskaryosis, 22 endometrial cancers (24.7%), 11 cervical cancers (12.3%), 15 cases of cervical intraepithelial neoplasia (16.8%), one adenocarcinoma in situ , and one vaginal intraepithelial neoplasia. The average age of this group was 54.3 years and approximately one‐third presented with postmenopausal bleeding.…”

Section: Introductionmentioning

confidence: 99%

A clinical review of borderline glandular cells on cervical cytology

Mohammed

Lavie

Lopes

et al. 2000

BJOG

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Objective To review the diagnoses and diagnostic pathway of women presenting with borderline glanDesign Retrospective review.Population Forty-three women referred to the hospital department over a 32-month period.Methods Review of the casenotes for the demographic data, previous cervical cytology andor histology report, indication for the smear resulting in borderline glandular cells, colposcopic findings, diagnostic and/or treatment procedures, final diagnosis and current status.Results The average age was 36.7 years. Twenty-four women (56%) had clinically significant lesions: seven women (16%) presented with cancers, of which one was endometrial in origin, and 17 (40%) with intraepithelial neoplasia (CIN and cervical glandular intraepithelial neoplasia (CGIN)). Sixtyseven percent of all clinically significant lesions were of squamous origin. Thirty-seven had histological diagnosis, while six went on to cytological surveillance. Colposcopy was the most significant predictor for clinically significant lesions (P < 0-05). Punch biopsies and loop excisions were diagnostic when based on abnormal colposcopic findings. Brush cytology was appropriate follow up for asymptomatic, premenopausal women with no colposcopic abnormality. In addition, endometrial sampling was recommended in the peri-and postmenopausal women.Conclusion Borderline glandular cells have a high incidence of clinically significant lesions. Immediate referral for colposcopy and assessment is strongly recommended in women with two borderline glandular smears to avoid delays in potential cancer diagnosis. dular cells on cervical cytology. To outline the basis of clinical approach of these women.

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“…The predictive value of abnormal glandular cytology is compromised by several factors. Firstly, the positive predictive value, for preneoplastic and neoplastic pathology, of smears showing a high‐grade glandular cytologic abnormality varies between 17% and 95.7% (31,42–45) . Secondly, the occurrence of benign conditions that mimic cervical glandular neoplasia cytologically (46) .…”

Section: Management Of Cervical Glandular Abnormalitiesmentioning

confidence: 99%

The pathology and management of endocervical glandular neoplasia

El‐Ghobashy¹,

Shaaban²,

Herod³

et al. 2005

Int J Gynecol Cancer

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The incidence of cervical glandular intraepithelial neoplasia and adenocarcinoma is rising, and our limited knowledge about these lesions presents the gynecologist with a management dilemma. Recently, pathologists have paid increasing attention to the diagnosis and pathogenesis of adenocarcinoma of the cervix. Although there is no uniformity in the management of these lesions, nonradical surgery appears to give satisfactory results especially in young women who want to preserve their fertility. This review focuses on the issues surrounding the histologic diagnosis of endocervical glandular abnormalities, including their classification, and discusses the management of cervical preinvasive glandular disease, including follow-up after treatment.

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A study to determine the underlying reason for abnormal glandular cytology and the formulation of a management protocol

Cited by 12 publications

References 5 publications

A retrospective clinical audit of cervical smears reported as ‘glandular neoplasia’

A retrospective clinical audit of cervical smears reported as ‘glandular neoplasia’

A clinical review of borderline glandular cells on cervical cytology

The pathology and management of endocervical glandular neoplasia

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