A Study to assess the association of vitamin D (serum 25 hydroxy vitamin D3) and vitiligo

Pillai, Rathish T; Dinachandran, Athira

doi:10.18231/2581-4729.2019.0002

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flowchart of literature inclusion and exclusion is shown in Figure 1. Briefly, a total of 125 articles were retrieved in the initial stage, with 15 articles and 5 articles investigating the association of 25(OH)D (12,14,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) and 25(OH)D 3 (13,15,(44)(45)(46) with risk of vitiligo included in the final analysis, respectively. In total, we collected the data of 987 patients and 770 controls for 25(OH)D, and 305 patients and 321 controls for 25(OH)D 3 between 2012 and 2020 in this metaanalysis.…”

Section: Patients With Vitiligo Had a Lower Level Of 25(oh)d Relative To Controlsmentioning

confidence: 99%

Circulating Vitamin D Levels and Risk of Vitiligo: Evidence From Meta-Analysis and Two-Sample Mendelian Randomization

et al. 2021

View full text Add to dashboard Cite

Background: The association between circulating vitamin D levels and risk of vitiligo was inconsistent among observational studies, and whether these observed associations were causal remained unclear. Therefore, we aimed to evaluate the effect of vitamin D on the risk of vitiigo using meta-analysis and Mendelian randomization (MR).Methods: At the meta-analysis stage, literature search was performed in PubMed and Web of Science to identify eligible observational studies examining the association of circulating 25-hydroxyvitamin D [25(OH)D] or 25-hydroxyvitamin D3 [25(OH)D3] levels with risk of vitiligo up to April 30, 2021. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) of 25(OH)D and 25(OH)D3 in patients with vitiligo relative to controls were pooled. Then at the MR stage, genetic instruments for circulating 25(OH)D (N = 120,618) and 25(OH)D3 (N = 40,562) levels were selected from a meta-analysis of genome-wide association studies (GWAS) of European descent, and summary statistics of vitiligo were obtained from a meta-analysis of three GWASs including 4,680 cases and 39,586 controls. We used inverse-variance weighted (IVW) as main method, followed by weighted-median and likelihood-based methods. Pleiotropic and outlier variants were assessed by MR-Egger regression and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test.Results: In the meta-analysis, patients with vitiligo had a lower level of circulating 25(OH)D compared with controls [SMD = −1.40; 95% confidence interval (CI): −1.91, −0.89; P < 0.001], while no statistically significant difference of 25(OH)D3 between vitiligo cases and controls was found (SMD = −0.63; 95% CI: −1.29, 0.04; P = 0.064). However, in the MR analyses, genetically predicted 25(OH)D [odds ratio (OR) = 0.93, 95% CI = 0.66–1.31, P = 0.66] and 25(OH)D3 levels (OR = 0.95, 95% CI = 0.80–1.14, P = 0.60) had null associations with risk of vitiligo using the IVW method. Sensitivity analyses using alternative MR methods and instrumental variables (IV) sets obtained consistent results, and no evidence of pleiotropy or outliers was observed.Conclusion: Our study provided no convincing evidence for a causal effect of 25(OH)D or 25(OH)D3 levels on the risk of vitiligo. Further longitudinal and experimental studies, as well as functional studies are warranted to elucidate the role of vitamin D in the development of vitiligo.

show abstract

Section: Patients With Vitiligo Had a Lower Level Of 25(oh)d Relative To Controlsmentioning

confidence: 99%

Circulating Vitamin D Levels and Risk of Vitiligo: Evidence From Meta-Analysis and Two-Sample Mendelian Randomization

et al. 2021

View full text Add to dashboard Cite

show abstract

“… 33 Finally, a total of 31 articles were included in this meta-analysis. 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 The PRISMA flow diagram for this meta-analysis has been shown in Fig. 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The available studies in the literature are inconsistent on Vit-D levels and Hypovitaminosis D is still controversial in vitiligo. 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 In this updated systematic review and meta-analysis on vitiligo and Vit-D levels (ViViD Study), the serum Vit-D levels and their association with variables like age, disease duration, affected Body Surface Area (BSA), and Vitiligo Activity and Severity Index (VASI) were studied in vitiligo patients as compared to controls. A subgroup meta-analysis was conducted to study Vit-D levels in relation to gender, skin type, Vitiligo type, disease activity, vitiligo history, autoimmune comorbidities, and indoor-outdoor job status of vitiligo patients.…”

Section: Introductionmentioning

confidence: 99%

Decreased circulatory levels of Vitamin D in Vitiligo: a meta-analysis

Varikasuvu

Aloori²,

Varshney

et al. 2021

Anais Brasileiros de Dermatologia

View full text Add to dashboard Cite

Background The serum Vitamin D status in patients with vitiligo is ambiguous when compared to controls. A systematic review and updated meta-analysis were conducted to evaluate the association between Vitamin D and vitiligo. Methods Relevant studies were identified by searching PubMed and other databases. The random effects model was used to obtain standardized mean differences and pooled correlation coefficients. Meta-regression and sub-group analyses were conducted to explore heterogeneity. The presence of publication bias and the study robustness were tested using funnel plot and sensitivity analyses, respectively. Results This meta-analysis finally included 31 studies. Compared with controls, vitiligo patients showed significantly decreased serum Vitamin D levels (standardized mean difference = −1.03; p < 0.0001). The sub-group analysis showed that vitiligo patients with indoor/urban work had a significantly lower Vitamin D level when compared to their outdoor/rural counterparts (standardized mean differences = −0.45; p = 0.03). The sensitivity analysis indicated that no single study had a significant influence on the overall outcome, suggesting the robustness of this meta-analysis. Study limitations Varied sample sizes and heterogeneous study populations from different countries are the limitations of this study. However, the between-study heterogeneity has been addressed by the random-effects model with meta-regression and sensitivity analyses. Conclusions This meta-analysis showed significantly decreased Vitamin D level in vitiligo, and its association with indoor/outdoor type of work of vitiligo patients. This study highlights the need to assess Vitamin D status for improving its level in vitiligo.

show abstract

Evaluation of serum levels of vitamin D and CXCL10 in patients with generalized vitiligo and their relation to disease severity

Mekkawy

Seddik

Shehata

2023

Egyptian Journal of Dermatology and Venereology

View full text Add to dashboard Cite

Background Vitiligo is an acquired, common, autoimmune, pigmentary defect of the skin. Vitamin D (VitD) plays a physiological role in photo-induced melanogenesis in the skin. It was found that VitD levels decline in autoimmune illnesses. Recently, there has been growing interest in the role of vitamin D3 in the pathogenesis of vitiligo and its change after treatment. The chemokine CXCL10 was found to be raised in the serum of patients with vitiligo. Few studies have evaluated its relation to the severity of the disease. Aims To establish a link between both serum VitD and serum CXCL10 and vitiligo, besides evaluating their possible relation to disease severity. Patients and methods This study was conducted on 30 patients with generalized vitiligo and 30 healthy individuals without age and sex limitations. Serum VitD and CXCL10 levels were measured for both patients with vitiligo and controls and were re-evaluated after 12 weeks for patients with vitiligo. The Vitiligo Area Scoring Index was calculated for the patient group at baseline and after 12 weeks. Results Serum VitD was found to be significantly lower in patients with vitiligo than controls, whereas serum CXCL10 was significantly higher in patients than healthy controls. Changes in serum CXCL10 at the end of the study period positively correlated with changes in Vitiligo Area Scoring Index of patients with vitiligo. Conclusion There is a strong relationship between both serum VitD and CXCL10 and vitiligo. Serum CXCL10 levels change in relation to disease severity.

show abstract

A Study to assess the association of vitamin D (serum 25 hydroxy vitamin D3) and vitiligo

Cited by 3 publications

References 0 publications

Circulating Vitamin D Levels and Risk of Vitiligo: Evidence From Meta-Analysis and Two-Sample Mendelian Randomization

Circulating Vitamin D Levels and Risk of Vitiligo: Evidence From Meta-Analysis and Two-Sample Mendelian Randomization

Decreased circulatory levels of Vitamin D in Vitiligo: a meta-analysis

Evaluation of serum levels of vitamin D and CXCL10 in patients with generalized vitiligo and their relation to disease severity

Contact Info

Product

Resources

About