A study to assess serum levels of superoxide dismutase and catalase in senile cataract patients with and without diabetes mellitus at tertiary care hospital

Mohanty, Lipa; Madhusmita, Behera; Ajay, P

doi:10.18203/2320-6012.ijrms20162786

Cited by 5 publications

(6 citation statements)

References 4 publications

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“…These associations are inconsistent with the previous studies [33,34]. However, the relationship between CAT and T2D risk on the age subgroup analyses contradicted the previous findings, which revealed that older people have a higher T2D risk than the younger ones [31,35]. The proposed reason for the conflicting results on CAT activity could be a cellular response as a compensatory adaptation to OS during the downregulation of CAT, genetic mechanisms and body fat accretion among individuals, and a disturbance in the protein tyrosine kinase and protein tyrosine phosphatase in cell signaling pathways during aging on impaired CAT activity [48].…”

Section: Discussioncontrasting

confidence: 91%

“…A similar trend was observed by Palekar et al (2016), who observed a significant decrease in CAT levels in participants with T2D when compared with those in controls [34]. Another study by Lipa et al revealed that the serum CAT levels were significantly lower in participants with T2D than in those without T2D [31].…”

Section: Discussionsupporting

confidence: 71%

“…Hou et al (2021) reported a statistically significant decrease in the SOD activity in participants with T2D when compared with that in healthy individuals [5]. Similarly, Lipa et al (2016) concluded that low serum levels of SOD significantly correlated with the increased risk of T2D and cataract development among individuals with T2D [31]. Other previous studies also reported that patients with T2D have a reduced activity of serum SOD when compared with those without T2D [10,32].…”

Section: Discussionmentioning

confidence: 86%

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Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais

et al. 2023

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Oxidative stress contributes to defective antioxidant defenses, which may lead to type 2 diabetes (T2D). This study aimed to elucidate the T2D risks and antioxidant defenses by investigating the superoxide dismutase (SOD), catalase (CAT), vitamin A, and vitamin E status. We observed 102 participants aged 35–66 years from Sung Neon, Nakhon Ratchasima, Thailand. The blood samples were collected to measure the SOD, CAT, vitamin A, and vitamin E concentrations. The SOD and CAT activities were inversely associated with T2D risk. When compared with participants in the highest quartile of SOD and CAT, those in the lowest quartile for T2D risk obtained multivariable-adjusted odds ratios of 4.77 (SOD: 95% confident interval CI, 1.01–22.40; p = 0.047) and 4.22 (CAT: 95% CI, 1.07–16.60; p = 0.039). The possible influencing factors (e.g., physical activity, total cholesterol, and triglyceride) might mediate the association of SOD and CAT with T2D risk. Meanwhile, the relationship between vitamin A and vitamin E concentrations and T2D risk was insignificant. In conclusion, lower concentrations of antioxidant enzyme activity (SOD and CAT) may be an additional risk factor for T2D.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 86%

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Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais

et al. 2023

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“…Some reports suggest that the levels of CAT and GPx enzyme activities may decrease in a diabetic and metabolic syndrome (Mets) patients 42–44. Also decreased CAT activities were found in patients with various types of cancer, including lymphoma, breast cancer, head and neck cancer, gynaecological and urological cancer 45.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

Lakzaei

Khodabandehloo

Hosseini

et al. 2019

Postgraduate Medical Journal

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BackgroundResveratrol is a naturally occurring polyphenol compound mainly found in grapes and red wine. The evidence has suggested that resveratrol has an antioxidant effect. However, the results are inconsistent and inconclusive. Thus, we conducted a systematic review and meta-analysis to evaluate the effect of resveratrol supplementation on markers of oxidative stress.MethodsWe searched PubMed, ISI Web of Science, EMBASE, Scopus and the Cochrane library up to December 2018 to identify randomised controlled trials (RCTs) assessing resveratrol supplementation effects on oxidative markers. Heterogeneity, publication bias, risk of bias and subgroup analysis were analysed. This meta-analysis was conducted in accordance with the guidelines of the Preferred ReportingItems for Systematic Reviews and Meta-Analysis (PRISMA).ResultsMeta-analysis of data from 12 RCTs did not support significant effect of resveratrol supplementation on circulating levels of superoxide dismutase (SOD) (standardized mean difference (SMD) (1.12), (95% CI −0.91 to 3.1), p=0.28), catalase (CAT) (SMD (−0.07), (95% CI −1.4 to 1.3), p=0.92) and glutathione peroxidase (GPx) (SMD (−0.76), (95% CI −2.56 to 1.04), p=0.40). Although, resveratrol supplementation increased significantly circulating total antioxidant capacity (TAC) concentrations (SMD (0.52), (95% CI −0.02 to 1.07), p=0.05). Severe heterogeneity was observed between studies, and no obvious publication bias was observed in included RCTs.ConclusionCollectively, our findings of available RCTs did no show any benefit of resveratrol supplementation on SOD, CAT and GPx except for TAC. Well-designed RCTs are necessary to confirm these results.

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“…Controversial reports on changes in serum/plasma ecSOD activity of T2DM patients have been published. In some, a decrease in the activity was observed [ 16 ], whereas in others an increase was reported [ 17 , 18 ]. In this study, a significant decrease in serum ecSOD activity in T2DM patients and a substantial reduction in the DR group were observed, according to the reference range of serum ecSOD activity (129–216 U/mL) in our laboratory.…”

Section: Discussionmentioning

confidence: 99%

Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus

et al. 2018

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Extracellular superoxide dismutase (ecSOD) is the major extracellular scavenger of reactive oxygen species and associated with the diabetic complication in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the serum ecSOD activity in Chinese patients with different stages of diabetic retinopathy (DR) and evaluate the association between the serum ecSOD activity and the severity of DR. A total of 343 T2DM patients were categorized into three groups: nondiabetic retinopathy (NDR) group, nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group. Serum ecSOD activities were measured by the autoxidation of the pyrogallol method. In this study, 271, 46, and 26 patients were enrolled in the NDR, NPDR, and PDR groups, respectively. We found a significantly decreased trend of serum ecSOD activity among NDR subjects (118.0 ± 11.5 U/mL) compared to NPDR subjects (108.5 ± 11.9 U/mL) (P < 0.001) and NPDR subjects compared to PDR subjects (102.7 ± 12.4 U/mL) (P = 0.041). Serum ecSOD activity was an independent risk factor for DR (OR = 0.920, P < 0.001) and was associated with the progression of DR. Serum ecSOD activity might be a biomarker for DR screening and evaluation of the clinical severity of DR in Chinese T2DM patients.

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A study to assess serum levels of superoxide dismutase and catalase in senile cataract patients with and without diabetes mellitus at tertiary care hospital

Cited by 5 publications

References 4 publications

Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais

Inverse Correlation of Superoxide Dismutase and Catalase with Type 2 Diabetes among Rural Thais

Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials

Serum Extracellular Superoxide Dismutase Is Associated with Diabetic Retinopathy Stage in Chinese Patients with Type 2 Diabetes Mellitus

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