A Study Protocol for Estimating the Association of De Ritis ratio (AST/ALT) with Outcomes in Patients of Acute Ischemic Stroke

Abstract

Background: One of the clinical endpoints of atherosclerosis is stroke, the most prominent clinical manifestation of cerebrovascular disease. It is a cerebral blood vessel disease that nourishes the brain. A global health concern is stroke. It is the second most prevalent cause of death worldwide and the fourth leading cause of disability. The underlying pathophysiology in most ischemic strokes is atherosclerosis. Few studies have shown that high AST/ALT ratio was independently corelated with the increased danger of complication and death in cerebrovascular event patients. This research aims to assess the correlation of De Ritis ratio in cases of acute ischaemic stroke at admission and their prognosis at 3 months.
 Methodology: This will be a observational cross sectional study. About 65 patients with signs suggestive of acute ischemic will be examined. A comprehensive laboratory examination will be carried out. For confirmation of the diagnosis, all patients will undergo CT SCAN or MRI assessment. The primary results of stroke severity on admission will be obtained according to the NIHSS scale. The ranking for NIHSS would be dichotomized to less than 5 and more than 5. For all cases diagnosed with acute ischemic stroke, AST/ALT RATIO will be computed. Data will be analysed with relevant statistical tests.
 Results Expected: We expect a significant correlation between serum de-Ritis ratio and prognosis of acute ischaemic stroke.

Association of Serum Calcium With Infarct Size and Severity in Acute Ischemic Stroke: A Rural Hospital-Based Cross-Sectional Study

“…There was no significant association of calcium with NIHSS and Barthel Index as noted by Sivasubramaniyam et al in 2017. Ishfaq et al in their study of 138 patients revealed that low levels of serum calcium may be related to more severe clinical findings at the stroke onset [ 14 , 17 ]. A study by Borah et al revealed that total calcium, albumin-corrected calcium, and ionized calcium had a statistically significant negative correlation with infarct size [ 5 , 18 ].…”