A study on the TNF-α system in Caucasian Spanish patients with alcoholic liver disease

Auguet, Teresa; Vidal, Francesc; López‐Dupla, Miguel; Broch, Montserrat; Gutiérrez, Cristina; Olona, Montserrat; Oltra, C; Aguilar, Carmen; González, Eva; Quer, Joan-Carles; Sirvent, Juan J.; Richart, C

doi:10.1016/j.drugalcdep.2007.07.008

Cited by 24 publications

(16 citation statements)

References 51 publications

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“…In order to be comprehensive and to have sufficient number of studies to perform a meta-analysis, we adopted a broad phenotype including AD and AA. Only two studies included exclusively AD participants [10,25] ; four others included AD and AA diagnoses (AD subgroup represented between 48.5 and 62% of the total sample of cases) [17,24,38] whereas four earlier studies did not assess psychiatric morbidity [23,26,37] .…”

Section: Discussionmentioning

confidence: 99%

“…The 'A' allele has been related to increased TNF-␣ expression [22] . A positive association was reported between 'A' allele excess and alcohol-related steatohepatitis [23] , alcoholic liver cirrhosis [24] , and advanced liver disease [17] , but not confirmed in three other studies of AALD [25][26][27] .…”

Section: Tnf-␣ -238 (Rs361525 G/a)mentioning

confidence: 99%

“…Three of them included subgroups of patients without liver disease [17,24,25] . A first metaanalysis including all patients (4,040 alleles) found a significant association (z = 2.31, p = 0.02; OR = 1.36, CI: 1.05-1.76) and an absence of heterogeneity (Q = 2.01, p = 0.85 with I 2 = 0%) ( fig.…”

Section: Tnf-␣ -238 (Rs361525 G/a)mentioning

confidence: 99%

“…Three of them included subgroups of patients without liver disease [17,24,25] . A first metaanalysis including all patients ( …”

Section: Tnf-␣ -308 (Rs1800629 G/a)mentioning

confidence: 99%

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Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis

Kébir

Gorsane²,

Blecha³

et al. 2011

Eur Addict Res

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The aim of the present work was to systematically review all association studies of inflammation genes with alcohol dependence/alcohol abuse (AD/AA) and to perform a meta-analysis. Odds ratios (ORs) were estimated by contrasting the ratio of counts of the ‘high-risk’ versus ‘low-risk’ alleles in AD/AA cases versus controls. Data reported in at least three published studies were available for four genetic polymorphisms [TNF-α -238 (rs361525, G/A); TNF-α -308 (rs1800629, G/A); IL-1RA (VNTR [86 bp]_n); IL-10 -592 (rs1800896, C/A)]. In total, nine meta-analyses were performed. Of these, only the TNF-α -238 polymorphism showed a significant association with AD/AA (OR = 1.36, 95% CI: 1.05–1.76). This risk remained significant and increased slightly when we considered only patients with advanced alcohol-related liver disease (AALD) (OR = 1.5, 95% CI: 1.13–1.98) but not when we considered only patients without AALD (OR = 1.08, 95% CI: 0.5–2.35). Sensitivity analysis showed that this genetic association is derived from the AALD phenotype rather than from AD. Our approach is limited by our phenotype definition; some studies included chronic heavy drinkers (minimal daily consumption of 80 g for a minimal duration of 10 years) but without a standardized psychiatric assessment.

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Section: Discussionmentioning

confidence: 99%

Section: Tnf-␣ -238 (Rs361525 G/a)mentioning

confidence: 99%

Section: Tnf-␣ -238 (Rs361525 G/a)mentioning

confidence: 99%

“…Three of them included subgroups of patients without liver disease [17,24,25] . A first metaanalysis including all patients ( …”

Section: Tnf-␣ -308 (Rs1800629 G/a)mentioning

confidence: 99%

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Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis

Kébir

Gorsane²,

Blecha³

et al. 2011

Eur Addict Res

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“…Adiponectin levels were measured using a radioimmunoassay kit (Linco Research Inc., St. Charles, MO). Interleukin (IL)-6, soluble tumour necrosis factor receptor 1 (sTNFR1) and serum tumor necrosis factor receptor 2 (sTNFR2) levels were assessed as previously described by our group [13,22]. …”

mentioning

confidence: 99%

Zinc alpha‐2 glycoprotein is implicated in dyslipidaemia in HIV‐1‐infected patients treated with antiretroviral drugs

et al. 2012

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ObjectivesTreated HIV-1-infected patients with lipodystrophy often develop insulin resistance and proatherogenic dyslipidaemia. Zinc alpha-2 glycoprotein (ZAG) is a recently characterized adipokine which has been shown to be involved in the development of obesity and metabolic syndrome in uninfected subjects. We assessed the relationship between circulating ZAG levels and metabolic derangements in HIV-1-infected patients receiving antiretroviral drugs. MethodsPlasma ZAG levels were assessed in 222 individuals: 166 HIV-1-infected patients treated with antiretroviral drugs (77 with lipodystrophy and 89 without lipodystrophy) and 56 uninfected controls. Plasma ZAG levels were assessed by enzyme-linked immunosorbent assay (ELISA) and were correlated with fat distribution abnormalities and metabolic parameters. ResultsHIV-1-infected patients had lower plasma ZAG levels compared with uninfected controls (P < 0.001). No differences were found in ZAG plasma levels according to the presence of lipodystrophy, components of the metabolic syndrome or type of antiretroviral treatment regimen. Circulating ZAG levels were strongly determined by high-density lipoprotein cholesterol (HDLc) in men (B = 0.644; P < 0.001) and showed a positive correlation with total cholesterol (r = 0.312; P < 0.001) and HDLc (r = 0.216; P = 0.005). ConclusionsHIV-1-infected patients have lower plasma ZAG levels than uninfected controls. In infected patients, plasma ZAG levels are in close relationship with total cholesterol and HDLc.Keywords: antiretroviral drugs, dyslipidaemia, HIV, lipodystrophy, metabolic syndrome, zinc alpha-2 glycoprotein Accepted 21 October 2011 IntroductionProlonged use of antiretroviral drugs in HIV-1-infected patients is associated with several toxicities that limit their success. Among chronic toxicities, the appearance of the so-called lipodystrophy syndrome is of concern. Lipodystrophy includes a series of body morphological changes consisting of peripheral fat atrophy, truncal fat accumulation or both [1]. Lipodystrophy is not a merely aesthetic abnormality; unfortunately it is often Adipose tissue, in addition to its well-known role in lipid storage, is an important secretory organ. Adipokine deregulation is known to be involved in the aetiology of IR and metabolic syndrome (MS) in uninfected subjects, but the relationship between adipokines, lipodystrophy and its metabolic complications is a subject of controversy [4][5][6]. Recently, abnormalities in circulating levels of several adipokines, such as leptin and adiponectin, have been described in individuals with HIV-1-related lipodystrophy [7]. Zinc alpha-2 glycoprotein (ZAG) is a recently characterized adipokine that is a focus of special interest. This protein appears to be involved in lipid metabolism and body weight regulation and it may also be involved in the development of IR. In contrast to other adipokines, ZAG gene expression, similarly to expression of the adiponectin gene, is reduced in obesity [8][9][10]. However, it is unclear whether circulating leve...

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Relationship between gene polymorphisms of two cytokine genes (TNF-α and IL-6) and occurring of lung cancers in the ethnic group Han of China

Liang

Liu

et al. 2012

Mol Biol Rep

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Tumor necrosis factor (TNF) is a cytokine involved in inflammation and TNF-α might be synthesized ectopically in malignant tumors. Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. The present study is to investigate the relationship between genetic polymorphisms of the TNF-α and IL-6 genes and susceptibility to lung cancers in the ethnic group Han of North China. The genotypes in the -238G locus of TNF-α gene and the -572C locus of the IL-6 gene were determined by PCR-RFLP method in 138 patients with lung cancers and 138 healthy individuals. Software PHASE 1.0 was used to analyze the experimental data. The non-conditional logistic regression model was used to analyze the statistical association of genotypes and susceptibility in two groups adjusted by multiple factors. We found that the TNF-α and IL-6 polymorphisms may be a critical risk for the genetic susceptibility to lung cancers in the ethnic group Han of North China. SNP polymorphisms at the -238G locus of TNF-α gene and the -572C locus of the IL-6 gene were detected by the RFLP-PCR method. We found that high rates of single-base G-to-A alteration at the -238G locus of both alleles and high rates of single-base C-to-G alteration at the -572C locus of both alleles correlated with occurring of lung cancers. It is possible that the SNP markers at the -238G locus of TNF-α gene and the -572C locus of the IL-6 gene serve as biological markers of lung cancers upon further study in the future.

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A study on the TNF-α system in Caucasian Spanish patients with alcoholic liver disease

Cited by 24 publications

References 51 publications

Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis

Association of Inflammation Genes with Alcohol Dependence/Abuse: A Systematic Review and a Meta-Analysis

Zinc alpha‐2 glycoprotein is implicated in dyslipidaemia in HIV‐1‐infected patients treated with antiretroviral drugs

Relationship between gene polymorphisms of two cytokine genes (TNF-α and IL-6) and occurring of lung cancers in the ethnic group Han of China

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