A Study on the Teachers’ Job-satisfaction and Burnout of Elementary School Special Teachers

Yi, Seong yong; Yi, Seung-hoon

doi:10.34262/kadd.2020.24.3.204

Cited by 1 publication

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“…The in vivo toxicity study showed that there were no pathological changes in the heart, liver, spleen, lung, and kidney after administration of BA‐SAN gel. Meanwhile, BA and SAN have been used as clinical drugs for a long time, [ 21,53 ] and the above evidence showed that we were convinced that the unmodified carrier‐free BA‐SNA hydrogel had good biocompatibility.…”

Section: Resultsmentioning

confidence: 98%

Natural Carrier‐Free Binary Small Molecule Self‐Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response

Wang

Yuan

et al. 2022

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Methicillin‐resistant Staphylococcus aureus (MRSA)‐infected skin wounds have caused a variety of diseases and seriously endanger global public health. Therefore, multidimensional strategies are urgently to find antibacterial dressings to combat bacterial infections. Antibacterial hydrogels are considered potential wound dressing, while their clinical translation is limited due to the unpredictable risks and high costs of carrier excipients. it is found that the natural star antibacterial and anti‐inflammatory phytochemicals baicalin (BA) and sanguinarine (SAN) can directly self‐assemble through non‐covalent bonds such as electrostatic attraction, π–π stacking, and hydrogen bonding to form carrier‐free binary small molecule hydrogel. In addition, BA‐SAN gel exhibited a synergistic inhibitory effect on MRSA. And its plasticity and injectability allowed it to be applied as a wound dressing. Due to the matched physicochemical properties and synergistic therapeutic effects, BA‐SAN gel can inhibit bacterial virulence factors, alleviate wound inflammation, promote wound healing, and has good biocompatibility. The current study not only provided an antibacterial hydrogel with clinical value but also opened up new prospects that carrier‐free hydrogels can be designed and originated from clinically used small‐molecule phytochemicals.

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Section: Resultsmentioning

confidence: 98%