A study on the role of gelatin in methacrylic-acid-based gel dosimeters

Hayashi, Shin-ichiro; Yoshioka, Munenori; Usui, Shuji; Haneda, Kiyofumi; Kondo, Takahiro; McAuley, Kimberley B.; Tominaga, Takahiro

doi:10.1016/j.radphyschem.2010.01.014

Cited by 17 publications

(11 citation statements)

References 29 publications

(34 reference statements)

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“…This is possible due to chemical changes that occur after irradiation, where free radicals formed from water molecules initiate a gelation process [2]. The coexistence of monovinyl-and divinyl-monomers capable of polymerizing produces threedimensional networks (gels) which retain their initial spatial distribution for long periods thanks to the presence of a gelatin matrix [3]. This matrix preserves the dose distribution, minimizing the diffusion of the monomers and gels.…”

Section: Introductionmentioning

confidence: 99%

Analytical and rheological studies of modified gel dosimeters exposed to X-ray beams

Romero

Mattea

Vedelago

et al. 2016

Microchemical Journal

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The need to know the dose of X-rays to be applied to patients suffering diseases such as cancer requires accurate and stable dosimetric devices. Currently, the use of gelatin-based dosimeters has yielded excellent results but lack adequate thermal stability. In this paper a chemical modification of the gelatin (at concentrations typically used for the preparation of dosimeters) using glutaraldehyde as a cross-linking agent is proposed. Through rheological studies it was found that modified gelatin with glutaraldehyde concentrations between 0.15 and 0.50 % w / v show better thermal stability with an increase in elastic modulus of up to 100 times at 37°C and convenient reaction times for the preparation of the dosimeters. Subsequently, a mathematical model to easily predict the elastic modulus of materials prepared with different concentrations of gelatin and glutaraldehyde was proposed. The analytical response of modified and unmodified materials was evaluated and no significant alteration of the dosimetric sensitivity was found in the dosimeters (based on itaconic acid and N, N'-methylenebisacrylamide) when an X-ray irradiation dose from 0 to 300 Gy was applied. It was found that the best thermal A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT2 stability of dosimeters prepared with modified gelatin would decrease the loss of information between the irradiation process and the absorbance reading, thereby improving the stability and linear correlation of data.Overall, the results indicated that the dosimeters could be modified as proposed and achieve significant improvements regarding to their thermal stability, without changing significantly the usual preparation process.

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Section: Introductionmentioning

confidence: 99%

Analytical and rheological studies of modified gel dosimeters exposed to X-ray beams

Romero

Mattea

Vedelago

et al. 2016

Microchemical Journal

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“…On the other hand, the linearity is the goodness of fit of this experimental data for this gel composition, i.e. 0.997 [8], [9], [19], [27]. The linearity indicates the linear relationship to ensure accurate measurement.…”

Section: Resultsmentioning

confidence: 97%

Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter

Chang

Hsieh²

2012

PLoS ONE

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In this study, a two-level full factorial design was used to identify the effects of the interactions between compositions in an N-isopropylacrylamide (NIPAM) gel dosimeter involving the following variables: (A) gelatin, (B) NIPAM, (C) the crosslinker N, N′-methylene-bis-acrylamide (Bis), and (D) the antioxidant tetrakis (hydroxymethyl) phosphonium chloride (THPC). The dose range was from 0 Gy to 5 Gy. Optical computed tomography was used to scan the polymer gel dosimeter. Each component was set to two levels for all four variables, including (A) 4% and 6%, (B) 4% and 6%, (C) 2% and 4%, as well as (D) 5 and 15 mM. Response surface methodology and a central composite design were adopted for the quantitative investigation of the respective interaction effects on the dose response curve of the gel. The results showed that the contributions of the interaction effects, i.e., AB (6.22%), AC (8.38%), AD (7.74%), BC (9.44%), ABC (18.24%), BCD (12.66%), and ABCD (13.4%), were greater than those of the four main effects, accounting for over 76.08% of the total variability. These results also indicated that the NIPAM gel recipe with the highest sensitivity was at 40%C (mass fraction of Bis).

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“…The complex will diffuse within gelatin physically through a weak hydrogen bond between the dyed-metal complex and gelatin. Upon g-irradiation, these bonds were broken and the effect of g transfer directly to the complex, so this is considered the main cause to the effective role of gelatin to enhance sensitivity (Gafar & El-Ahdal, 2015;Hayashi et al, 2010). Scheme 1 shows the molecular structure of azo Diphenyl carbazone "DPC".…”

Section: Preparation Of Gel Samplesmentioning

confidence: 99%

“…This means that the same prepared complex but it exists in different media reflecting its applications and uses so that both of DPC/Cr-(liquid-gel) complex could be applied in wide range of applications as mentioned before. Recent studies explain the important and effective role of gelatin in this process (Gafar & El-Ahdal, 2015;Hayashi et al, 2010), that gelatin is a polypeptide of a structure in which various amino acids are linked by peptide bonds (eNHe COe), which is similar to a hydrogen bond. The amino groups in the dosimeter solution play an important role in enabling free radical polymerization in DPC/Cregel dosimeters.…”

Section: Radiation Dose Response Curvesmentioning

confidence: 99%

Spectrophotometric properties of azo dye metal complex and its possible use as radiation dosimeter

Gafar¹,

El-Kelany²,

El-Shawadfy³

2018

Journal of Radiation Research and Applied Sciences

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a b s t r a c tThe current work describes the physico-chemical studies of two dosimetry systems. Aqueous solution of 1, 5 diphenyl carbazone (DPC) incorporating with chromium (III) to form a colored azo dye metal complex in two methods liquid and gel. Under the effect of g-irradiation, the colored complex undergoes visual color change from red to colorless. The prepared complex can be used as a dosimeter and applicable in dose range 0.2e6; 0.02e1 kGy for both dosimetry systems. Electrical conductivity was measured and reflecting its application as sensor. The dosimetric characteristics of this complex solution were investigated spectrophotometrically at ‫ג‬ max at 540 nm. Complex sensitivity for g-radiation, pre and post-irradiation storage under different conditions were illustrated. Moreover, the applications of these results of metal uptake resembles to dosimeter.

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A study on the role of gelatin in methacrylic-acid-based gel dosimeters

Cited by 17 publications

References 29 publications

Analytical and rheological studies of modified gel dosimeters exposed to X-ray beams

Analytical and rheological studies of modified gel dosimeters exposed to X-ray beams

Effect of Composition Interactions on the Dose Response of an N-Isopropylacrylamide Gel Dosimeter

Spectrophotometric properties of azo dye metal complex and its possible use as radiation dosimeter

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