A Study on the Pattern of Genetic Inheritance of Polycystic Ovarian Syndrome

Muralidhara, Krithika; Adhikari, Prabha; Dv, Muralidhara

doi:10.9734/bjmmr/2015/13461

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Muralidhara et al in KMC, Mangalore did a study in 2012, where the mean age among patients with PCOS was 27±7.1 which is comparable to our study. 25 In a study done by Spandane et al in 2017, the mean age among PCOS patients was 27±5 which is comparable to the study. 26 In the present study, most of the PCOS patients lived in the urban area 72.8% and in rural area 34%.…”

Section: Discussionsupporting

confidence: 70%

Clinical and hormonal profile of patients diagnosed with polycystic ovarian syndrome at tertiary care hospital in Tamil Nadu

Sathiya

Renuka

Famida

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: In recent years due to the changing sedentary life style, irregular periods and infertility has become a major concern. There are many causes for infertility out of which ovulatory disorders contribute to a great extend. The main objective of the study was to assess the clinical and hormonal profile of patients diagnosed with polycystic ovarian disease at tertiary care hospital in Tamil Nadu.Methods: This study was a cross sectional study and was carried out at the Department of Obstetrics and Gynaecology at a tertiary care hospital of Tamil Nadu. The study was done for a period of 6 months. For confirming polycystic ovaries, patients were interviewed thoroughly about their menstrual and fertility history. Blood investigations like LH, FSH were done on D2/D3 of menstrual cycle. 125 patients with PCOS were included in this study. The data was analysed with SPSS-IBM (V.22.0) software.Results: The patients having polycystic ovaries were higher in women of 21-30 years of age. BMI was more than 25. Infertility was found that 57%, hirsutism 45%, oligomenorrhoea 21% and amenorrhea 20%. On day 2, mean serum LH was 5.9±3.6 and serum FSH was 3.9±2.3. This study showed that the proportion of menstrual complaints is reported more in higher age group. Likewise lower income group presented with menstrual complaints. This was found to be statistically significant (P value <0.05).Conclusions: The study showed that patients diagnosed to have PCOS overweight. PCO in obese women had more severe ovulatory dysfunction. Infertility was the most common complaint.

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Section: Discussionsupporting

confidence: 70%

Clinical and hormonal profile of patients diagnosed with polycystic ovarian syndrome at tertiary care hospital in Tamil Nadu

Sathiya

Renuka

Famida

et al. 2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…In a study done by Muralidhara et al in KMC Mangalore in 2012 mean age among PCOS patients was 27+/-7.1 which is comparable to our study. 10 In our study among 100 PCOS patients, 74% were married and 26% were unmarried. Among married women, about 31.1% were parous and 68.9% were nulliparous.…”

Section: Discussionmentioning

confidence: 56%

“…In a study conducted by Muralidhara et al in 86 PCOS patients, they found that 33% had FBS >100mg%, PPBS were high in about 25% and impaired glucose tolerance was reported by 17%. 10 In obese women, excess insulin and androgens may contribute to the development of the PCOS and metabolic syndrome. The android pattern of fat distribution may be the result as well as the cause of hyperandrogenism, setting up a vicious circle of hyperinsulinism, hyperandrogenism, central adiposity and metabolic abnormalities.…”

Section: Discussionmentioning

confidence: 99%

A study on the clinical, biochemical and hormonal profile of polycystic ovary syndrome patients attending tertiary care hospital

Spandana

Shetty

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder of reproductive age affecting 5% to 10% of women worldwide. It is a heterogenous, multifactorial, complex genetic disorder. PCOS receives a considerable attention because of its high prevalence and metabolic, reproductive and cardiovascular consequences.Methods: A cross sectional observation study of 100 PCOS patients was carried out between January 2014 to July 2015 in Gynaecology out-patient and Infertility OPD, Justice K. S. Hegde charitable hospital, Mangalore. The clinical, biochemical and hormonal profile of these patients were analysed and correlation was done between clinical features and biochemical and hormonal profile.Results: The prevalence of PCOS was 6.3% in the Gynaecology out-patient visits and 37.14% among infertile women. Menstrual irregularity was the most common complaint accounting for 31% followed by infertility (23%). Elevated leutinizing hormone and elevated LH: FSH was significant in irregular menstrual group. The prevalence of metabolic syndrome in our study was 21.3%. Spearmans correlation between various clinical and laboratory parameters showed menstrual cycle and body mass index(BMI) had a fair positive correlation and was significant. WHR (waist hip ratio) showed 21 times risk for metabolic syndrome.Conclusions: The study showed that most of our polycystic ovary syndrome subjects were hirsute, with central obesity and overweight or obese. Oligomenorrhea was the most common presentation. Among the various risk factors studied, WHR (waist hip ratio) showed 21 times risk for metabolic syndrome. Obese women with PCOS had more severe ovulatory dysfunction and need more attention for their appropriate management.

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Fractalkine and apoptotic/anti-apoptotic markers in granulosa cells of women with polycystic ovarian syndrome

et al. 2020

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A Study on the Pattern of Genetic Inheritance of Polycystic Ovarian Syndrome

Abstract: Aims: Inheritance of polycystic ovary syndrome (PCOS) is still a controversy. Our study aims to analyze the family history of PCOS features and related metabolic disturbances including the male members to determine the mode of their inheritance.

Cited by 3 publications

References 32 publications

Clinical and hormonal profile of patients diagnosed with polycystic ovarian syndrome at tertiary care hospital in Tamil Nadu

Clinical and hormonal profile of patients diagnosed with polycystic ovarian syndrome at tertiary care hospital in Tamil Nadu

A study on the clinical, biochemical and hormonal profile of polycystic ovary syndrome patients attending tertiary care hospital

Fractalkine and apoptotic/anti-apoptotic markers in granulosa cells of women with polycystic ovarian syndrome

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