A study on the microheterogeneity of alpha‐fetoproteins produced by yolk sac and germ cell tumors

Yamamoto, Ritsu; Ohkouchi, Toshihiro; Wakui, Yukio; Minobe, Shinichiro; Watari, Hidemichi; Shimizu, Kayoko; Satomura, Shinji; Sakuragi, Noriaki

doi:10.1034/j.1600-0412.2003.00170.x

Cited by 6 publications

(1 citation statement)

References 16 publications

(20 reference statements)

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“…The percentage of AFP reactive with three lectins LCA, Phaseolus vulgaris leukoagglutinin and Ricinus communis agglutinin using a radioimmunoassay showed a significant difference in the glycan composition of AFP from patients with GCT (n = 7) in comparison with AFP from embryonal fluids (n = 11) [118].…”

Section: Performance Of Glycosylated Afp As a Tc Biomarkermentioning

confidence: 92%

Glycan Analysis as Biomarkers for Testicular Cancer

et al. 2019

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The U.S. Preventive Services Task Force does not recommend routine screening for testicular cancer (TC) in asymptomatic men, essentially because serological testicular cancer (TC) biomarkers are not reliable. The main reason is that two of the most important TC biomarkers, α-fetoprotein (AFP) and human chorionic gonadotropin (hCG), are not produced solely due to TC. Moreover, up to 40% of patients with TC do not have elevated serological biomarkers, which is why serial imaging with CT is the chief means of monitoring progress. On the other hand, exposure to radiation can lead to an increased risk of secondary malignancies. This review provides the first comprehensive account of the applicability of protein glycoprofiling as a promising biomarker for TC with applications in disease diagnostics, monitoring and recurrence evaluation. The review first deals with the description and classification of TC. Secondly, the limitations of current TC biomarkers such as hCG, AFP and lactate dehydrogenase are provided together with an extensive overview of the glycosylation of hCG and AFP related to TC. The final part of the review summarises the potential of glycan changes on either hCG and AFP as TC biomarkers for diagnostics and prognostics purposes, and for disease recurrence evaluation. Finally, an analysis of glycans in serum and tissues as TC biomarkers is also provided.

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Section: Performance Of Glycosylated Afp As a Tc Biomarkermentioning

confidence: 92%

Glycan Analysis as Biomarkers for Testicular Cancer

et al. 2019

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Tumour Markers in Andrology

Bracke

Andrology for the Clinician

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Integrated analysis of the rhesus monkey liver transcriptome during development and human primary HCC AFP-related gene expression

Wang

et al. 2021

Molecular Therapy - Nucleic Acids

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Embryonic development and tumorigenesis have a certain degree of similarity. Alpha-fetoprotein (AFP), a protein related to embryonic development, is a well-known biomarker for the diagnosis and prognosis of hepatocellular carcinoma (HCC). In this study, we analyzed the differences in gene expression profiles and molecular mechanisms in human HCC tissues from patients in AFP high (serum AFP level R 25 ng/mL) and AFP low (serum AFP level < 25 ng/mL) groups. The results indicated that AFP high HCC has more malignant biological characteristics. Single-sample gene set enrichment analysis (ssGSEA) showed significantly higher levels of genes expressed in dendritic cells, neutrophils, and natural killer cells in the AFP low group than in the AFP high group. Then, we defined a rhesus monkey fetal liver developmental landscape and compared it to the HCC gene expression profile. The gene signatures of AFP high HCC tissues were similar to those of early embryonic liver tissues. In this study, we comprehensively analyzed the rhesus monkey liver transcriptome during development and human primary HCC AFP-related gene expression profiles and clarified the function of AFP in the occurrence and development of HCC from the perspective of developmental biology, which might provide a new perspective on the pathogenesis of HCC.

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A study on the microheterogeneity of alpha‐fetoproteins produced by yolk sac and germ cell tumors

Cited by 6 publications

References 16 publications

Glycan Analysis as Biomarkers for Testicular Cancer

Glycan Analysis as Biomarkers for Testicular Cancer

Tumour Markers in Andrology

Integrated analysis of the rhesus monkey liver transcriptome during development and human primary HCC AFP-related gene expression

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