A study on the intrapapillary capillary loop detected by narrow band imaging system in early oral squamous cell carcinoma

Sekine, Riyo; Yakushiji, Takashi; Tanaka, Youichi; Shibahara, Takahiko

doi:10.1016/j.ajoms.2014.11.010

Cited by 10 publications

(11 citation statements)

References 23 publications

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“…The combined use of high‐definition endoscopes and NBI technology, however, facilitates the visualisation of changes in the degree of dilation, tortuosity, meandering and calibre of IPCL. An increase in dilation, distortion, branching, elongation and density is more pronounced the further a lesion is along the carcinogenesis continuum, and this has been confirmed by histology and three‐dimensional imaging (Fujii et al , ; Funayama et al , ; Sekine et al , ). When there is an increase in microvascular density, the lesion is inherently thickened and significantly correlated with a higher rate of subepithelial invasion (Fujii et al , ).…”

Section: Narrow Band Imagingmentioning

confidence: 83%

“…The blue light centred at 415 nm corresponds to the main peak absorption spectrum of haemoglobin and penetrates the superficial mucosal layer to a depth of 0.16 mm to enhance the intrapapillary capillary loops (IPCLs). Blood vessels in the deeper mucosal and submucosal layers are visible due to the deeper penetration of the green light centred at 540 nm, which reaches a depth of 0.24 mm (Gono et al , , ; Sekine et al , ).…”

Section: Narrow Band Imagingmentioning

confidence: 99%

“…Dilated and a crossing IPCL pattern is type II (Figure ), and further elongation and meandering of IPCLs is type III (Figure ). Both type II and type III are generally associated with non‐neoplastic and inflammatory lesions (Yang et al , , ); however, type III has also been found to have a higher incidence of dysplasia and carcinoma in situ (CIS) (Yang et al , ; Sekine et al , ). In contrast, type IV is characterised by IPCL pattern destruction, large vessels and angiogenesis, and is indicative of neoplasia (Figure ).…”

Section: Narrow Band Imagingmentioning

confidence: 99%

“…In contrast, type IV is characterised by IPCL pattern destruction, large vessels and angiogenesis, and is indicative of neoplasia (Figure ). The range for sensitivity and specificity for differentiating benign lesions from neoplastic ones when using types III and IV as the criterion is high, between 85% to 89% and 93% to 95%, respectively (Yang et al , ; Sekine et al , ). When more than one IPCL pattern type is present in a lesion, the most advanced is designated the IPCL type for that lesion (Takano et al , ).…”

Section: Narrow Band Imagingmentioning

confidence: 99%

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Narrow band imaging: clinical applications in oral and oropharyngeal cancer

Farah

2016

Oral Diseases

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Narrow Band Imaging (NBI) is an endoscopic optical imaging enhancement technology that improves the contrast of mucosal surface texture, and enhances visualisation of mucosal and submucosal vasculature. White light is filtered to emit two 30-nm narrow bands of blue (415 nm) and green light (540 nm) light simultaneously, the former corresponding to the main peak absorption spectrum of haemoglobin, and the latter allowing visualisation of blood vessels in the deeper mucosal and submucosal layers. NBI has been used to better assess oral potentially malignant disorders (OPMD), identify oral and oropharyngeal squamous cell carcinoma (SCC), and to define surgical margins of head and neck malignancies. NBI shows great potential in improving detection rates of OPMD, facilitating better assessment of oral and oropharyngeal SCC, and reducing the risk of recurrence for oral SCC. Although further research is required to better understand and define intrapapillary capillary loop (IPCL) patterns and to relate these with clinical, histopathological and molecular parameters especially for early mucosal changes, there is building evidence to recommend its use as the new gold standard for endoscopic assessment in head and neck oncology.

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Section: Narrow Band Imagingmentioning

confidence: 83%

Section: Narrow Band Imagingmentioning

confidence: 99%

Section: Narrow Band Imagingmentioning

confidence: 99%

Section: Narrow Band Imagingmentioning

confidence: 99%

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Narrow band imaging: clinical applications in oral and oropharyngeal cancer

Farah

2016

Oral Diseases

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“…FVL occurs because the wavelength of blue light is absorbed by hemoglobin. Furthermore, angiogenesis occurs due to cell proliferation [ 41 ], and an inflammatory response is triggered by the immune response, resulting in FVL [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Morikawa

Shibahara

Nomura

et al. 2020

Cancers

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Background: Oral cancer screening is important for early detection and early treatment, which help improve survival rates. Biopsy is the gold standard for a definitive diagnosis but is invasive and painful, while fluorescence visualization is non-invasive, convenient, and real-time, and examinations can be repeated using optical instruments. The purpose of this study was to clarify the usefulness of fluorescence visualization in oral cancer screening. Methods: A total of 502 patients, who were examined using fluorescence visualization with optical instruments in our hospitals between 2014 and 2019, were enrolled in this study. The final diagnosis was performed by pathological examination. Fluorescence visualization was analyzed using subjective and objective evaluations. Results: Subjective evaluations for detecting oral cancer offered 96.8% sensitivity and 48.4% specificity. Regarding the objective evaluations, sensitivity and specificity were 43.7% and 84.6% for mean green value, 55.2% and 67.0% for median green value, 82.0% and 44.2% for coefficient of variation of value, 59.6% and 45.3% for skewness, and 85.1% and 75.8% for value ratio. For the sub-analysis of oral cancer, all factors on objective and subjective evaluation showed no significant difference. Conclusions: Fluorescence visualization with subjective and objective evaluation is useful for oral cancer screening.

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Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study

Deganello

Paderno

Morello³

et al. 2020

The Laryngoscope

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Objective: Oral lichen planus (OLP) is a chronic mucocutaneous immune-mediated disease affecting 1% to 4% of the worldwide population. Development of malignant lesions is reported but only affects a minority of patients. The aim of our study was to assess the diagnostic potential of narrow band imaging (NBI) in OLP patients; focusing on the identification of high-grade dysplasia/carcinoma in newly developed lesions. Methods: Prospective evaluation of 56 patients with histopathologic diagnosis of OLP and presenting newly developed lesions not responding to medical treatment. All lesions were assessed by high-definition (HD) white light (WL) and HD-NBI endoscopy. All patients underwent biopsy regardless of the appearance at HD-WL and HD-NBI. Histology was defined as "positive" in case of high-grade dysplasia or carcinoma. Results: Five lesions (9%) were diagnosed as high-grade dysplasia/carcinoma. In this setting, overall diagnostic potential of HD-NBI was optimal, with a sensitivity of 100% (95% CI, 48-100), specificity of 96% (95% CI, 86-99), negative predictive value of 100% (95% CI, not calculable), positive predictive value of 71% (95% CI, 39-91), and accuracy of 96% (95% CI, 88-100). Conclusions: Despite the diffuse inflammatory pattern derived from OLP, NBI improved the diagnostic accuracy and the capability to detect high-grade dysplasia/carcinoma.

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A study on the intrapapillary capillary loop detected by narrow band imaging system in early oral squamous cell carcinoma

Cited by 10 publications

References 23 publications

Narrow band imaging: clinical applications in oral and oropharyngeal cancer

Narrow band imaging: clinical applications in oral and oropharyngeal cancer

Non-Invasive Early Detection of Oral Cancers Using Fluorescence Visualization with Optical Instruments

Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study

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