A Study on the Impact of Aflatoxin on Human Reproduction

Uriah, Nduka; Ibeh, Isaiah Nnanna; Oluwafemi, Flora

doi:10.2307/3583204

Cited by 48 publications

(28 citation statements)

References 10 publications

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“…This indication is further supported by a case control study in Nigeria on higher aflatoxin levels in blood and semen of infertile human males with abnormal sperm profiles than in fertile males (Uriah, Ibeh, and Oluwafemi 2001).…”

Section: Nutrition and Health Implicationssupporting

confidence: 54%

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

Ayalew¹,

Hoffmann²,

Lindahl³

et al. 2016

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Focusing the 2015 Annual Trends and Outlook Report (ATOR) on nutrition will contribute to a broader understanding of the critical role of nutrition in achieving international, continental, and national economic growth targets through agriculture, food security, and nutrition. This report presents information and analysis in support of evidence-based policy making that should inform the second generation of CAADP national investment plans now being developed. This is an important moment for shaping the region’s future and ensuring that the much-needed agriculture-led growth and development agenda can simultaneously deliver on improving nutrition, saving lives, improving productivity and health, and curbing nutrition-related diseases and the associated public health expenditures. These investment plans should address not only the usual elements of undernutrition but also widespread micronutrient deficiencies (termed “hidden hunger”) and the growing problem of overweight and obesity that is associated with economic growth.1 introduction 2 The African union policy environment toward enabling action for nutrition in Africa 3 Africa’s progress toward meeting current nutrition targets 4 Economic development and nutrition transition in Ghana: taking stock of food consumption patterns and trends 5 Making African agriculture and food systems work for nutrition: what has been done, and what needs to be done? 6 Lessons learned from the evaluation of Helen Keller International’s enhanced homestead food production program 7 The role of biofortification as part of more diverse diets in Africa: progress, challenges, and opportunities 8 The role of mycotoxin contamination in nutrition: the aflatoxin story 9 The challenges, opportunities, and lessons learned in evidence-informed decision making in Africa 10 Evaluating nutrition-sensitive programs: challenges, methods, and opportunities 11 Supporting multisectoral action: capacity and nutrition leadership challenges facing Africa 12 Tracking key CAADP indicators and implementation processes 13 Summary and policy recommendations: toward a nutrition revolution for AfricaReportPRIFPRI1; ReSAKSS; HarvestPlus; B Promoting healthy food systemsDSGD; WCAO; ESAO; HarvestPlus; PHND; A4NH; MTIDCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

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Section: Nutrition and Health Implicationssupporting

confidence: 54%

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

Ayalew¹,

Hoffmann²,

Lindahl³

et al. 2016

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“…Infertile men with high concentrations of aflatoxins in semen had decreased sperm counts and increased incidence of sperm abnormalities (Uriah et al 2001). Thus, there is an imminent link between chronic exposure of men to aflatoxins and male reproductive health.…”

Section: Discussionmentioning

confidence: 99%

“…Aflatoxins or their metabolites can reach the testis (Bukovjan et al 1992) and be present in the semen through this route (Picha et al 1986, Ibeh et al 1994, Uriah et al 2001. Infertile men with high concentrations of aflatoxins in semen had decreased sperm counts and increased incidence of sperm abnormalities (Uriah et al 2001).…”

Section: Discussionmentioning

confidence: 99%

“…Although a great deal is known about aflatoxins, little is known about aflatoxin exposure and the resulting health effects in developing countries (Strosnider et al 2006). Thus, though male reproductive toxic effects of aflatoxins in humans have not yet been investigated, such an effect cannot be eliminated in the light of reports coming from domestic and experimental animals (Faridha et al 2007 and the references therein) and also from a human study correlating aflatoxin content of semen and semen parameters of infertile men (Uriah et al 2001).…”

Section: Introductionmentioning

confidence: 95%

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Spermatotoxic effect of aflatoxin B1 in rat: extrusion of outer dense fibres and associated axonemal microtubule doublets of sperm flagellum

Kunnathodi

Periasamy²,

Sahabudeen³

et al. 2008

Reproduction

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Male Wistar rats were treated with aflatoxin B1 (AFB1). Live as well as methanol-fixed cauda epididymal spermatozoa were stained with acridine orange (AO) and ethidium bromide (EB) and observed under a fluorescence microscope. Giemsa-stained smears were observed in a bright field microscope. Unstained smears were observed with phase contrast illumination. The axoneme of more than 10% of the spermatozoa of treated rats had the outer dense fibres (ODFs), in varying numbers, and the associated axonemal microtubule doublets of the flagellum extruded either at midpiece-principal piece junction or connecting piece. This could be perceived in all light microscopic preparations, but AO-EB staining offered an advantage of the assessment of the viability as well. TEM observation of sections of the testis and cauda epididymidis also revealed ODF extrusion, as seen in the transverse sections of sperm flagella missing one or more ODFs and the associated axonemal microtubule doublets. In a few such sections, the extruded elements were seen in the cytoplasm, outside the mitochondrial sheath or peripheral sheath. Marginal to severe mitochondrial pathologies were observed in the spermatozoa and elongated spermatids, suggesting a link between AFB1-induced sperm mitochondrial pathology and extrusion of ODFs. However, the possibility that AFB1 treatment would disrupt the cytoskeletal proteins of the flagellum, resulting in the extrusion of ODFs, cannot be excluded. This sperm abnormality is reported for the first time as produced by a dietary toxin. Dietary aflatoxins, therefore, could also be contributory factors for the deterioration of the reproductive health of men.

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“…Furthermore, in the study of Uriah et al (2001) blood and semen samples were collected from 55 adult Nigerians comprising 30 infertile and 25 fertile control individuals, and screened for the presence of aflatoxins. Blood and semen aflatoxin levels in infertile men ranged from 700 to 1392 ng/ml and 60 to 148 ng/ml, respectively, values significantly higher than the concentrations of the toxin in fertile men.…”

Section: Menmentioning

confidence: 99%

Effects of aflatoxins on male reproductive system: A review

Kourousekos¹,

Theodosiadou

2018

J Hellenic Vet Med Soc

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ABSTRACT. Mycotoxins constitute toxic substances produced by certain species of fungi. Among other mycotoxins, aflatoxins are considered to be really dangerous, since they are characterized as carcinogenic for animals and humans. The consumption of aflatoxins through feeds or foods could lead to deleterious effects on animals' or humans' health. Research on animals has shown that the general body condition as well as some of the blood parameters, mainly those of the liver could be negatively affected with aflatoxin administration. Regarding the reproductive system, although not extensively studied, some investigators support the negative effects of aflatoxins either on females or on males. More specifically, in male, the size and weight of the genital organs, the spermatogenesis, the number, the motility and the morphology of sperm cells as well as hormones' concentrations could be affected after exposure of the animals to aflatoxins, making infertility problems more frequent. Most studies refer to laboratory and less to productive animals, while only two studies refer to the possible problems of infertility on men due to aflatoxins. Since reproduction consists one of the most important sectors of animal husbandry, special attention should be paid to nutrition so that the possibility of the aflatoxin consumption by animals would be eliminated, the animal health especially regarding the reproductive system would be protected and economic losses would be ameliorated.

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A Study on the Impact of Aflatoxin on Human Reproduction

Cited by 48 publications

References 10 publications

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

Achieving a nutrition revolution for Africa: The road to healthier diets and optimal nutrition

Spermatotoxic effect of aflatoxin B1 in rat: extrusion of outer dense fibres and associated axonemal microtubule doublets of sperm flagellum

Effects of aflatoxins on male reproductive system: A review

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