A Study on the Effects of a Combined Frusemide and Controlled Release Potassium Tablet (Diumide‐K Continus® tablets) on Gastrointestinal Mucosa

Background: Potassium supplements may cause mucosal damage of the gastrointestinal tract. Aim: To evaluate the effect of a new potassium supplement, potassium‐magnesium citrate (K‐Mag), on upper gastrointestinal mucosa and to compare it with an older potassium supplement, potassium citrate (Urocit‐K). Methods: A randomized and double‐blind study was conducted utilizing 36 healthy adults. Subjects were randomized into three groups: K‐Mag (70 mmol/day K, 35 mmol/day citrate and 17.6 mmol/day Mg); Urocit‐K (70 mmol/day K and 23.4 mmol/day citrate), and placebo. All subjects took 5 tablets b.d. of the allocated drug and 2 mg t.d.s. of glycopyrrolate for 7 days. On day 8, stool was examined for occult blood, a symptom score was calculated and an oesophagogastroduo‐denoscopy was performed. Mucosal lesions were scored at five anatomic sites. Results: Demographic characteristics and symptom score were similar in the three groups (< 10% with more than mild symptoms). There were no significant differences in the endoscopic scores at any site examined nor in the total scores among the three groups. Erosion or ulcers were found in 18% of K‐Mag, 23% of Urocit‐K and 17% of the placebo group. Conclusion: Short‐term use of K‐Mag does not appear to induce lesions in the upper gastrointestinal mucosa and its oral tolerance is similar to Urocit‐K or placebo.

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Comparative effects of three delivery systems of oral potassium on upper gastrointestinal mucosa

McLoughlin¹

1987

Int J Clinical Practice

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SummaryForty‐five healthy volunteers were recruited into a single‐blind randomly allocated parallel group study to determine the effects on the gastric mucosa of three different oral potassium supplements — (K‐Contin ContinusR) tablets, (Napp); Slow‐K tablets, (Ciba); Micro‐K Extencaps, (A H Robins).The volunteers were gastroscoped initially and after one week of treatment with one of the potassium tablets taken in conjunction with glycopyrrolate to delay gastric emptying. Post‐treatment, seven out of 15 volunteers taking Slow‐K tablets showed erosions and two showed hyperaemia only. Of the 15 taking Micro‐K, one showed erosions and two showed hyperaemia only. None of those given K‐Contin tablets showed erosions, but four showed hyperaemia only.

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A Study on the Effects of a Combined Frusemide and Controlled Release Potassium Tablet (Diumide‐K Continus® tablets) on Gastrointestinal Mucosa

Cited by 5 publications

References 21 publications

Gastrointestinal Lesions and Potassium Chloride Supplements

Gastrointestinal Lesions and Potassium Chloride Supplements

Effect of potassium‐magnesium citrate on upper gastrointestinal mucosa

Comparative effects of three delivery systems of oral potassium on upper gastrointestinal mucosa

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