A Study on the Effects of the Use of Propofol in Experimental Model Inferior Epigastric Island Flap on Ischemia-Reperfusion Injury

Abstract

Problems concerning vascular blood flow are the most frequently encountered ones after flap applications. The flap tissue starts to develop ischemia in patients with a vascular blood flow insufficiency. And reperfusion starts in those patients in whom the ischemia is temporary, triggering an ischemia-reperfusion injury depending on the duration of the ischemia. The aim of this study was to evaluate the effect of propofol, which is an anesthetic agent known to have an antioxidant effect and a free radical scavenging feature on the ischemia-reperfusion injury created on an experimental epigastric island flap.Thirty Sprague-Dawley rats were used in the study. The rats were divided into 3 groups of 10 rats each. Inferior epigastric artery-based abdominal flaps were prepared in all the groups. In group 1 (sham), the flap was elevated but no ischemia was applied. In groups 2 (control) and 3 (propofol), the flap was exposed to ischemia for 2 hours after it was elevated. All the rats were sacrificed and biochemical and histopathological assessments were made on the tissue samples taken on the 14th day. As a result of a comparison between the groups, the flap viability rates and the superoxide dismutase, total antioxidant capacity, and catalase values were found to be significantly higher (P < 0.001) in the propofol group while the malondialdehyde and total oxidative stress values were lower (P < 0.001). Based on the data obtained from the present study, the use of propofol was observed to have a protective effect against ischemia-reperfusion injuries in flap surgeries.

The Protective Effect of Propofol Against Ischemia–Reperfusion Injury in the Interlobar Arteries: Reduction of Abnormal Cx43 Expression as a Possible Mechanism

“…In the present study, HE staining of IRI-affected rat renal tissue (Fig. 1) and biochemical tests of intravenous blood ( Table 1) have confirmed that propofol has a protective effect against renal IRI, which is consistent with what other researchers have found [35]. Although the protective mechanism of propofol against renal ischemia-reperfusion is not fully clear, there have been studies suggesting that the gap junction protein Cx43 may be involved in the role of propofol [13,29,32,36].…”

“…It has also been found by multiple research teams that propofol has protective effects against IRI in multiple organs [33,34]. Propofol infusion has also been suggested to have protective effects against renal IRI in rats, but the underlying mechanism is not fully understood [10,13,35]. In the present study, HE staining of IRI-affected rat renal tissue (Fig.…”

A meta-analysis and systematic review of propofol on liver ischemia-reperfusion injury protection during hepatocellular carcinoma anesthesia surgery

“…Due to this, the scope of application in this study may be limited (19). The patients included in this study were mainly middle-aged and elderly patients, and propofol was used for anesthesia during hepatectomy of the hepatic port block (20). Therefore, there may be a clear distinction between minors and patients who have not undergone hepatectomy under anesthesia.…”

Genetic Diversity in Bibrik Sheep of Pakistan Elucidated through Molecular Characterization

“…As an important inflammatory cytokine, TNF-α mainly produced by the activation of monocytes/macrophages is involved in certain autoimmune diseases (Liu et al, 2019). Therefore, it can stimulate NO synthase (i-NOS) synthesis to release large amounts of NO (Eroglu et al, 2017). This will exacerbate peroxidation of membrane lipid and tissue damage.…”