A Study on the Effect of Tamsulosin in Ureteric Stent Related Morbidity

Abstract

Urolithiasis is a very common problem, and the challenges that it has posed has been instrumental in devising various means to tackle the stone burden. With better access, visualization and stone fragmenting techniques, end urological procedures have become a mainstay in treatment of stone despite the vast evidence supporting nonstented ureteroscopies, worldwide many urologists still prefer to place stents in majority of uncomplicated stone removal procedures in a bid to improve drainage, stone eases. Ureteric stents are associated with a wide spectrum of symptoms thereby producing considerable morbidity ranging from 80 to 98% and the discomfort caused varies from p Alpha adrenergic receptor like α1A and α1D have been documented to be distributed the in the lower urinary tract and the distal ureter and the use of alpha adrenergic receptor blockers like Tamsulosin are shown considerable promise in treating the stent related symptoms. Hence this study, was done in an effort to determine the effect of Tamsulosin in improving double-J stent related symptoms and quality of life following ureteral stent placement. This is a prospective study conducted from February 2013 to January 2014 at Government Stanley Hospital. A total of 180 patients were enrolled in this study after following the exclusion and inclusion criteria. Patients were prospectively randomized by random-number chart into two groups. Patients those of whom are prescribed non-selective α adrenergic receptor blockers like Tamsulosin following stenting, seem to benefit significantly because not only did they experience much lesser symptoms and bother, but they also improved over their symptoms with which they presented at admission. This would concur to the explicit influence these group of α adrenergic receptor blockers have over the lower urinary tract and gives them a definite role in treating patients afflicted with stent related morbidity.

A clinical study of effects of tamsulosin in ureteric stent related morbidity

“…Questionnaire score is high in non tamsulosin group and low in tamsulosin group. Similar results are found in our study and study done by Karrupaiah et al10 This comparison of IPSS score in non tamsulosin group pre-DJ stenting and post DJ stent removal suggest that, pre DJ stenting IPSS score is less and post DJ stent removal score increases and difference is significant. These results are same in both studies, i.e.…”

“…These results are same in both studies, i.e. Our study and study done by Karrupaiah et al10 Comparison of days of removal of DJ stent on IPSS score in both non tamsulosin and tamsulosin group.In our study, as the days of stent removal increases, in non tamsulosin group there is increase in IPSS score while in Tamsulosin group there is decrease in IPSS score, thus it is suggestive that if tamsulosin given for more longer duration its effects are more beneficial.In study done byNavanimitkul et al there is comparison between IPSS score of both, non tamsulosin group and Tamsulosin group at 2 week and 4 week post DJ. 11 Stenting, at 2 weeks post DJ stenting there is decrease in IPSS score of tamsulosin group (5.81) as compared to non tamsulosin group (7.81).…”

“…The findings of other study are similar to our study. So, there is no significant difference in both non tamsulosin and tamsulosin group at base line (Pre DJ stenting), in both our study and study done by Karrupaiah et al10 In comparing both study groups (Non tamsulosin and tamsulosin), total IPSS+QoL. Questionnaire score is high in non tamsulosin group and low in tamsulosin group.…”