A study on the differentiation between amorphous piroxicam:β-cyclodextrin complex and a mixture of the two amorphous components

Novel inclusion complex of ibuprofen tromethamine with cyclodextrins: Physico-chemical characterization

“…It should also be noted that in the present study, the two components (Ibu.T and ␤-CyD) were freeze-dried prior to preparation of their physical mixture. Therefore, the Ibu.T/␤-CyD complex isolated by freezedrying of the co-precipitated product is an inclusion complex and not just a dispersed mixture of the two amorphous components [17,26,[34][35][36]. On screening what was previously published in the literature [37][38][39][40][41][42], it was observed that guest and host components used to prepare complexes were not similarly treated, for example, by freeze-drying, co-precipitation, kneading, microwaving, or fluid-bed coating prior to measurements.…”

Study of paracetamol-containing pastilles produced by melt technology

“…There is no need for the use of extra organic solvents in the production, and there are therefore no residual solvents in the product and less environmentally harmful chemical waste, in contrast with other conventionally used techniques. Melt technology can result in amorphous products, which may have higher dissolution rates and bioavailability than those of the corresponding crystalline forms [1][2][3][4][5]. With a fusion method, a solid dispersion of the excipients and active agent can be prepared.…”

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

“…[62] successfully used thermal analysis for differentiating a PI/β-CD true inclusion complex and a physical mixture of the two amorphous components. As PI exhibits a high tendency to crystallize, the measurement of the melting peak area allows evaluation of the free PI content, irrespective of its amorphous or crystalline state.…”