Autism is currently a hot topic in the field of special education due to the high prevalence ratio of it. It is a highly variable neuro-developmental disorder that first appears during infancy or childhood and generally follows a steady course without remission. Overt symptoms gradually begin after the age of six months, become established by the age of two or three, and tend to continue through adulthood. It differs from any disabilities; the characteristics of autism generate additional stress for the parents and make the life of all the family very hard. Usually, mothers face the stressful challenges of raising a child with autism, they are concerned with their children's communication, education and related services, relationships with professionals and the independence of their children's future. Therefore, the aim of this study was to assess the influence of autism awareness on the psychological wellbeing of mothers caring for their children with autism. A descriptive research design was used. The study was conducted in two settings: the first one was the Special Needs Care Center in the Institute of postgraduate Childhood Studies which affiliated to Ain Shams University and the second one was the outpatient clinic for child psychiatric treatments at El Abassia mental health hospital. Sixty children accompanied by their mothers with certain criteria were recruited in the beginning of June 2015 to the end of August 2015. The study concluded that about two thirds of the studied sample had poor awareness regarding autism and there was a highly statistical significant relation between awareness, stress and psychological wellbeing among mothers of children with autism. The study recommended that media awareness must be increased to aid mothers in prompting tolerance and understanding of autism with a clear explanation. Furthermore, there is a necessity to counseling mothers to enhance their awareness about autism for modifying their behaviors and psychosocial skills.