A study on the change in HbA1c levels before and after non-surgical periodontal therapy in type-2 diabetes mellitus in generalized periodontitis

Munjal, Akshay; Jain, Yashika; Kote, Sowmya; Krishnan, Vineesh; Fahim, Rafi; Metha, Samruddhi Swapnil; Passi, Deepak

doi:10.4103/jfmpc.jfmpc_105_19

Cited by 10 publications

(5 citation statements)

References 7 publications

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“…[54][55][56] As far as the researchers are aware, most randomized controlled trials that concentrate on periodontal treatment in diabetic patients primarily aim to compare various treatment approaches and evaluate clinical parameters and enhancements in glycemic control. [57][58][59][60] Additionally, there is consistent evidence supporting the concept that nonsurgical periodontal therapy has a discernible positive effect on HbA1c levels in individuals with type 2 DM and chronic periodontitis.…”

Section: Discussionmentioning

confidence: 89%

Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis

Devina,

Halim,

Meivi

et al. 2024

Eur J Dent

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Objective This double-blind randomized clinical trial assessed the effectiveness of 0.2% hyaluronic acid (HA) gel as an adjunct to scaling and root planning (SRP) in patients with periodontitis and type 2 diabetes mellitus (DM), focusing on changes in clinical periodontal parameters, the expression of inflammatory mediators, and oral pathogens. Materials and Methods The randomized clinical trial involved 36 participants, 18 DM patients, and 18 healthy patients. The participants in each group were randomly assigned to receive placebo or HA gel after SRP. Gingival crevicular fluid and subgingival plaque samples were taken before treatment and at 4-week follow-up. Clinical parameters, interleukin-1β (IL-1β) and IL-10 levels, and proportions of Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were evaluated at baseline and follow-up. Statistical Analysis Paired t-test (parametric data) or Wilcoxon signed-rank test (nonparametric data) was used for intragroup comparison between baseline and follow-up, and comparisons between groups one-way analysis of variance test (parametric data) or Kruskal–Wallis test (nonparametric data). Results At 4 weeks, most of the groups showed statistically significant decreases (p ≤ 0.05) in various clinical and biomolecular parameters. However, there were exceptions: the pocket probing depth (PPD) and clinical attachment loss (CAL) parameter did not significantly decrease for the placebo (p > 0.05) non-DM group, and the IL-10 parameter in the DM HA gel group (p = 0.108). Regarding bacterial proportions, the non-DM and DM placebo group exhibited significant test results for Pg after 4 weeks (p ≤ 0.05). In the case of Fn bacteria proportions, they decreased in all groups, but these results were not statistically significant (p ≥ 0.05). An intergroup analysis revealed no significant differences (p ≤ 0.05) for bleeding on probing (BOP), PPD, and both proinflammatory and anti-inflammatory cytokines. Only clinical attachment loss (CAL) exhibited a statistically significant intergroup difference 0.042. Conclusion The use of 0.2% HA gel into periodontal pockets alongside SRP, for both diabetic and healthy individuals, showed no statistically significant variances in clinical, biomolecular, and microbiological measures.

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Section: Discussionmentioning

confidence: 89%

Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis

Devina,

Halim,

Meivi

et al. 2024

Eur J Dent

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“…Hyperglycemia in patients with diabetes not only predisposes them to periodontal disease and related low-grade systemic inflammation, but also to other oral complications, such as dental caries, candidiasis, burning mouth syndrome, salivary dysfunction, and xerostomia [ 37 ]. Periodontal treatment is beneficial for both local and systemic health, especially with diabetic patients [ 38 , 39 ]. Together with diabetes, the organ transplantation and the underlying liver disease complicates oral health; this emphasizes the importance of periodontal treatment in these patients.…”

Section: Discussionmentioning

confidence: 99%

Salivary Biomarkers and Oral Health in Liver Transplant Recipients, with an Emphasis on Diabetes

et al. 2021

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Salivary biomarkers have been linked to various systemic diseases. We examined the association between salivary biomarkers, periodontal health, and microbial burden in liver transplant (LT) recipients with and without diabetes, after transplantation. We hypothesized that diabetic recipients would exhibit impaired parameters. This study included 84 adults who received an LT between 2000 and 2006 in Finland. Dental treatment preceded transplantation. The recipients were re-examined, on average, six years later. We evaluated a battery of salivary biomarkers, microbiota, and subjective oral symptoms. Periodontal health was assessed, and immunosuppressive treatments were recorded. Recipients with impaired periodontal health showed higher matrix metalloproteinase-8 (MMP-8) levels (p < 0.05) and MMP-8/tissue inhibitor of matrix metalloproteinase 1 (TIMP1) ratios (p < 0.001) than recipients with good periodontal health. Diabetes post-LT was associated with impaired periodontal health (p < 0.05). No difference between groups was found in the microbial counts. Salivary biomarker levels did not seem to be affected by diabetes. However, the advanced pro-inflammatory state induced by and associated with periodontal inflammation was reflected in the salivary biomarker levels, especially MMP-8 and the MMP-8/TIMP-1 molar ratio. Thus, these salivary biomarkers may be useful for monitoring the oral inflammatory state and the course of LT recipients.

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“…Munjal et al . [ 13 ] evaluated and investigated changes in HbA1c levels before and after nonsurgical periodontal therapy in type-2 diabetes mellitus patients with generalized periodontitis. The selected participants were randomly allocated to two groups.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Effect of Periodontal and Prosthodontic Therapy on Glycemic Control in Patients with Diabetes

Bala

Kumari

2021

Journal of Pharmacy and Bioallied Sciences

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Background: Periodontitis is a chronic inflammatory disease of multifactorial etiology. The present study was conducted to assess the effect of periodontal and prosthodontic therapy on glycemic control in patients with diabetes. Materials and Methods: 80 type II diabetics patients of both genders were divided into Group I (periodontal and prosthodontic therapy) and Group II (Healthy). In control group, only oral hygiene instruction and mouth wash were prescribed. Results: Group I had 22 males and 18 females and Group II had 17 males and 23 females. The mean glycated hemoglobin level in Group I was 7.8% before and 6.7% after treatment and in Group II was 6.4% before and 6.2% after treatment. The difference was significant (P < 0.05). Conclusion: There was improvement in glycemic status in diabetic patients undergoing periodontal and prosthodontic therapy as compared to those not undergoing treatment.

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A study on the change in HbA1c levels before and after non-surgical periodontal therapy in type-2 diabetes mellitus in generalized periodontitis

Cited by 10 publications

References 7 publications

Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis

Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis

Salivary Biomarkers and Oral Health in Liver Transplant Recipients, with an Emphasis on Diabetes

Assessment of Effect of Periodontal and Prosthodontic Therapy on Glycemic Control in Patients with Diabetes

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