A study on the association of TNF-α-308, IL-6-174, IL-10-1082 and IL-1RaVNTR gene polymorphisms with rheumatic heart disease in Pakistani patients

Rehman, Sadia; Akhtar, Naveed; Saba, Nusrat; Munir, Saeeda; Ahmed, Waqar; Mohyuddin, Aisha; Khanum, Azra

doi:10.1016/j.cyto.2012.10.020

Cited by 34 publications

(27 citation statements)

References 34 publications

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“…Our results are similar to those of Settin et al [29], who reported that GCC frequency and GCC carriers were significantly greater in Egyptian RHD patients. In contrast, Rehman et al [22] could not confirm this finding in a Pakistani cohort of RHD patients. However, patients and controls were not in HWE for IL10-1082 in the Rehman et al study, which may have contributed a source of bias [34].…”

Section: Discussionmentioning

confidence: 79%

IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients

et al. 2015

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Rheumatic heart disease (RHD) is an inflammatory disease that develops following streptococcal infections. IL10 helps to balance immune responses to pathogens. IL10 polymorphisms have been associated with RHD, although results remain inconclusive. Our aim was to investigate the association between IL10 polymorphisms and RHD in Saudi Arabian patients. IL10 promoter polymorphisms (-1082A/G, -829C/T, and -592C/A) were genotyped in 118 RHD patients and 200 matched controls using the TaqMan allelic discrimination assay. There was a significant difference in IL10-1082 genotype frequency between patients and controls (p = 0.01). -1082G allele carriage (GG+GA vs AA) and the (-1082, -819, -592) GCC haplotype carriage were associated with an increased risk of RHD (p = 0.004, OR 2.1, 95% CIs 1.7-3.4 and p = 0.004, OR 2, 95% CIs 1.3-3.4, respectively). The ACC haplotype was associated with a decrease in RHD risk (p = 0.015, OR 0.6, 95% CIs 0.4-0.9). IL10 promoter polymorphisms may play an important role in the development of RHD and provide an opportunity for therapeutic stratification.

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Section: Discussionmentioning

confidence: 79%

IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients

et al. 2015

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“…Although many studies on the relationship between TNF-α gene 308G>A polymorphism and RHD have been performed so far, the results were still inconsistent15161718192021. These disparate findings may be partly due to limited sample size, false positive finding and publication bias.…”

mentioning

confidence: 99%

Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis

Zheng

Zhang

Jiang

2014

Sci Rep

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Rheumatic heart disease (RHD) remains a serious cardiovascular disorder across the world. Tumor necrosis factor alpha (TNF-α) codifies a potent immunomodulator and pro-inflammatory cytokine that mediates diverse pathological processes. A promoter 308G>A polymorphism in TNF-α has been implicated in RHD risk. However, the results remain controversial. Therefore, to evaluate more precise estimations of the relationship, a meta-analysis was performed. A total of 7 studies including 735 RHD cases and 926 controls were involved in this meta-analysis. Overall, our results revealed that there was a significant association with RHD risk in three genetic models (homozygous model: OR = 3.06, 95%CI = 1.22–10.60, P = 0.020; dominant model, OR = 2.03, 95%CI = 1.01–4.07, P = 0.048; and recessive model, OR = 4.26, 95%CI = 2.41–7.55, P < 0.001). Further ethnic population analysis found a significantly increased risk of RHD among Asians and Europeans. Interestingly, similar results were found among hospital-based studies. Begg's funnel plot and Egger's test did not reveal any publication bias. Taken together, this meta-analysis demonstrates that the TNF-α 308G>A polymorphism is associated with RHD susceptibility, and it contributes to the increased risk of RHD. However, additional well-designed studies with larger samples are warranted to confirm these findings.

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“…Settin et al [4] found that the frequency of AA and GG genotypes was higher in RHD than controls, which supported a role for the IL-10-1082 polymorphism in determining the risk of RHD. Rehman et al [12] reported that no association was found between IL-10-1082 polymorphism and susceptibility to RHD. Another study from Turkey reported no association between IL-10-1082 genotype and RHD, which are similar to our results [15].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Settin et al [4] demonstrated that all RHD cases had a significantly higher frequency of AA genotype of TNF-α-308 gene polymorphism (OR=5,7). Recently, Rehman et al [12] observed that the TNF-α-308 AA and GA genotypes were associated with susceptibility to RHD (OR=9,94 and OR=1,97, respectively). There is only one study in the Turkish population where an association of TNF-α-308 A allele with RHD has been observed (OR=3,3) [13].…”

Section: Discussionmentioning

confidence: 99%

Relationship of TNF-a-308, Il-10–1082 Gene Polymorphisms With the Severity and Susceptibility of Rheumatic Heart Disease in Turkish Children

et al. 2014

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A study on the association of TNF-α-308, IL-6-174, IL-10-1082 and IL-1RaVNTR gene polymorphisms with rheumatic heart disease in Pakistani patients

Cited by 34 publications

References 34 publications

IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients

IL10 Promoter Polymorphisms are Associated with Rheumatic Heart Disease in Saudi Arabian Patients

Tumor necrosis factor-alpha 308G>A polymorphism and risk of rheumatic heart disease: a meta-analysis

Relationship of TNF-a-308, Il-10–1082 Gene Polymorphisms With the Severity and Susceptibility of Rheumatic Heart Disease in Turkish Children

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