A study on the assessment of clinical profile and treatment pattern of multiple sclerosis in a tertiary care hospital

Amrutha, N.; Anand, Preet; Swathy, K. R.; Anila, K N; Kumar, Suresh

doi:10.5958/0974-360x.2020.01057.4

Cited by 2 publications

(1 citation statement)

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“…He et al discussed the efficacy and safety of magnesium sulfate which was combined with low-dose aspirin in the treatment of PIH [ 2 ]. Gao et al addressed the application of Doppler ultrasound in Omaha system nursing intervention (NI) to monitor the changes of important blood vessel hemodynamic indexes of pregnant women with PIH during pregnancy [ 3 ]. Vani et al studied the incidence of pregnancy hypertension syndrome and related risk factors [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Study on the Clinical Characteristics and Treatment of Obstetric Hypertension with Sequence Pattern Mining Algorithm

2021

Journal of Healthcare Engineering

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Aiming at the difficulty in setting the support threshold for sequential pattern mining algorithms and improving the effectiveness of the support threshold setting without the guidance of domain experts’ experience, an improved SPADE (sequential pattern discovery using equivalence classes) algorithm is proposed. By analyzing the relationship between the number of frequent sequences and the support threshold, the support threshold is dynamically selected. Using the electronic medical record data from a medical centre, the time-series relationship of the drugs taken by hypertension patients was extracted as the drug sequence dataset. By determining the optimal support threshold of the dataset, the frequent sequence set is mined, and the sequence rules are generated from the obtained regular sequences to visualize the sequence rules. The sequence rules of medication for hypertensive patients were combined with the patients’ physical indicators for the recommendation. For patients with obstetric hypertension, a combination of nifedipine and captopril is recommended. Through the comparison of the observation group and control group, we study the curative effect of various drugs. The results showed that the total effective rate of the observation group was about 96.6%; compared with the control group, the result indicated that the difference was significant ( P < 0.05). The comparison of blood pressure levels between the two groups after treatment also showed that the results of the observation group were ideal ( P < 0.05). In addition, the incidence of postpartum haemorrhage and perinatal complications in the observation group was also significantly reduced ( P < 0.05). Therefore, the combination of medication for pregnancy hypertension syndrome can effectively improve the treatment effect of the disease and reduce the rate of postpartum haemorrhage and the incidence of perinatal complications.

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Section: Introductionmentioning

confidence: 99%

Study on the Clinical Characteristics and Treatment of Obstetric Hypertension with Sequence Pattern Mining Algorithm

2021

Journal of Healthcare Engineering

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Are 5HT7 Receptors Possible Target for Multiple Sclerosis?

Justin

Murugan

Basavaraj

et al. 2023

RJPT

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Multiple sclerosis (MS) is a neurological condition with a complicated autoimmune component that mainly affects women in their forties and fifties. The disorder appears in several forms, ranging from episodic somatosensory impairment to progressive and irreversible central nervous system (CNS) injury. The fundamental cause of this disorder is lack of serotonin (5HT), a neurotransmitter with numerous immune effects. Decreased 5-HT levels or synthesis have also been related to increased proinflammatory cytokines in the CNS. Among several other proinflammatory cytokines, two prototypic pro-inflammatory cytokines, interleukin-1 (IL-1β) and tumor necrosis factor (TNF-α) have been identified as primary effectors of neuroinflammation's functional effects on neurodegeneration.TNF-α is a pleiotropic cytokine that regulates homeostasis, immunity, and inflammation and IL-1β is also a cytokine with neuroimmunological and neurophysiological functions. MS patients are usually on drugs that change the serotonergic system, because of increased clinical comorbidities and proven serotonin deficits. Several studies have shown that higher 5-HT levels have anti-inflammatory and immune-modulating properties, which could help to delay the progression of the disease.

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A study on the assessment of clinical profile and treatment pattern of multiple sclerosis in a tertiary care hospital

Cited by 2 publications

References 0 publications

Study on the Clinical Characteristics and Treatment of Obstetric Hypertension with Sequence Pattern Mining Algorithm

Study on the Clinical Characteristics and Treatment of Obstetric Hypertension with Sequence Pattern Mining Algorithm

Are 5HT7 Receptors Possible Target for Multiple Sclerosis?

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