A Study on the Antioxidative, Anti-inflammatory and Anti-thrombogenic Effects of Zanthoxylum piperitum DC. Extract

장미진,; 이순재,; 조성희,; 우미희,; 최정화,

doi:10.3746/jkfn.2006.35.1.021

Cited by 13 publications

(4 citation statements)

References 8 publications

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“…It has also been widely used for its diuretic, anti-inflammatory, anthelmintic, and other properties [10]. Recent studies on ZM have suggested that the methanol extracts from the plants exhibit antioxidative activities [11] supporting previous studies that have reported that plant extracts have antioxidant effects [12][13][14]. Several studies have suggested that antioxidant medicines may be an attractive treatment option for disuse muscle atrophy [15,16], but studies on disuse muscle atrophy using ZM have not yet been reported.…”

Section: Introductionmentioning

confidence: 68%

“…In addition, it has been reported that methanol and butanol extracts of plants showed high antioxidant activity, and the functional antioxidative compound was speculated to be flavonoids [13]. Moreover, the antioxidant activity of the root extracts, stem, and leaf of the Zanthoxylum piperitum was observed to be the most active between 0.05 -0.25 mg/mL in ethyl acetate and methylene chloride (1:1) [12]. Furthermore, it has been reported that ZM extracts have excellent antioxidant properties, preventing tooth decay [14].…”

Section: Discussionmentioning

confidence: 99%

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The Protective Effects of Zanthoxylum bungeanum Maxim Pharmacopuncture on Disuse Muscle Atrophy in Rat Gastrocnemius Muscle

Chung

Lee

et al. 2019

J Acupunct Res

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Background: This study aimed to investigate the protective effects of Zanthoxylum bungeanum Maxim pharmacopuncture on disuse muscle atrophy in the gastrocnemius muscle of rats. Methods: Thirty male 250 g Sprague-Dawley rats were distributed randomly into 3 groups. The left hindlimb immobilization was performed with casting tape for 2 weeks, and no treatment was given to the right hindlimb. Rats received pharmacopuncture and were injected daily on the BL57 with either 2 mL of Zanthoxylum bungeanum Maxim aqueous extract (ZM-W group), 1 mL pharmacopuncture of Zanthoxylum bungeanum Maxim ethanol extract (ZM-E group), or 2 mL normal saline (control group). After 2 weeks of immobilization, the weight of the whole gastrocnemius muscle was measured, and the morphology of both the left and the right gastrocnemius muscles were assessed by Hematoxylin and Eosin staining. To investigate the immobilizationinduced muscular apoptosis, the immunohistochemical analysis of BAX and Bcl-2 was carried out. Results: ZM-W and ZM-E significantly inhibited the reduction in weight of the left gastrocnemius muscle, the reduction in the left myofibrils, and the cross-sectional area of gastrocnemius, as compared with the control. Moreover, the ZM-W and ZM-E groups showed significantly reduced immunoreactivity for BAX, and increased immunoreactivity of Bcl-2 in left gastrocnemius muscle compared with the control group. Conclusion: These results suggest that Zanthoxylum bungeanum Maxim pharmacopuncture has protective effects against immobilization-induced muscle atrophy by regulating the activity of apoptosis-associated BAX / Bcl-2 proteins in the gastrocnemius muscle.

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Section: Introductionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Zanthoxylum bungeanum Maxim Pharmacopuncture on Disuse Muscle Atrophy in Rat Gastrocnemius Muscle

Chung

Lee

et al. 2019

J Acupunct Res

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“…Zanthoxylum piperitum is found in traditional herbal medicine and is reported to possess antibacterial, anti-inflammatory, and antioxidant effects [18,19]. Previous studies also confirmed its therapeutic effects on osteoar- Left hindlimb Left hindlimb…”

Section: Discussionmentioning

confidence: 88%

The Evaluation of the Single-Dose Toxicity and Safety of 4-Carvomenthenol in ICR Mice

Lim,

Kong,

Lee

et al. 2023

J Acupunct Res

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Background: 4-carvomenthenol[4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol] is a main component of Origanum vulgare L., Zanthoxylum piperitum (L.) DC., and other plants. It has been reported to exhibit anti-inflammatory, antibacterial, and anti-tumor effects. Furthermore, it is necessary to conduct a toxicity test on 4-carvomenthenol to ensure its safety. Methods: This study included 5-week-old Institute of Cancer Research mice that were categorized into 3 treatment groups (12, 25, and 50 mg/kg 4-carvomenthenol dose levels) and a control group (10% dimethyl sulfoxide, 40% polyethylene glycol 300, 5% Tween 80, and 45% normal saline injection of the final volume), with 5 male mice and 5 female mice per group. All groups were observed for clinical symptoms and body weight in a period of 14 days and were subjected to gross necropsy after euthanasia. Results: No deaths were recorded. No test substance-related clinical signs in the female mice of the 12 mg/kg dose group were observed. Abnormal gait was observed in 1 male from day 1 to day 3 in the 12 mg/kg dose group; 1−3 males from day 1 to day 7 and 1−5 females from day 1 to day 15 in the 25 mg/kg dose group; and 2−5 males and 2-5 females from day 1 to day 15 in the 50 mg/kg dose group. No test substance-related effect on the body weight and necropsy findings was observed. Conclusion:The results of this study suggested that the lethal dose of 4-carvomenthenol could be greater than 50 mg/kg. However, further research is needed, especially repeated-dose toxicity studies, to confirm the efficacy and safety of 4-carvomenthenol.

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“…이를 통해 초피 는 다양한 부위가 다양한 효능을 가지고 있음을 알 수 있다 6) . 상기 효능 중 항염증 작용은 잎이 가장 강하게 나타났다 7) . 1정(1,200 mg)당 초피나무잎 추출물 80 mg (6.7%), 포 도씨유 1,008.4 mg (84%), 대두레시틴 27.6 mg (2.3%), 밀납 84 mg (7%)으로 구성되었고, 시험2군은 1정당 초 피나무잎 추출물 160 mg (13.3%), 포도씨유 928.4 mg (77.4%), 대두레시틴27.6 mg (2.3%), 밀납 84 mg (7%) 으로 구성되었다.…”

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Evaluation of the Effectiveness and Safety of Zanthoxylum piperitum Leaf Extract against Mild Degenerative Osteoarthritis of Knee: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jeong

Lee

Yoon

et al. 2021

J Korean Med Rehabil

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A Study on the Antioxidative, Anti-inflammatory and Anti-thrombogenic Effects of Zanthoxylum piperitum DC. Extract

Cited by 13 publications

References 8 publications

The Protective Effects of Zanthoxylum bungeanum Maxim Pharmacopuncture on Disuse Muscle Atrophy in Rat Gastrocnemius Muscle

The Protective Effects of Zanthoxylum bungeanum Maxim Pharmacopuncture on Disuse Muscle Atrophy in Rat Gastrocnemius Muscle

The Evaluation of the Single-Dose Toxicity and Safety of 4-Carvomenthenol in ICR Mice

Evaluation of the Effectiveness and Safety of Zanthoxylum piperitum Leaf Extract against Mild Degenerative Osteoarthritis of Knee: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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