A Study on the Adverse Drug Reactions Induced by Anti Epileptic Drugs in the Epileptic Patients

Abstract

Epilepsy is a chronic disorder of the brain that affects people worldwide. The aim of this work was to study the adverse drug reactions (ADRs) induced by the antiepileptic drugs (AEDs) in epileptic patients. This prospective study was carried out for six months, from April 2014 to September 2014, in a tertiary teaching care hospital, Erode. The study included epileptic patients, both male and female of all age groups, undergoing treatment with AEDs. A total of 180 epileptic patients were monitored, 60% were male and 40% were females. Majority of the study population were adults. Majority of the epileptic patients were affected with generalized seizure (46.66%). Monotherapy was preferred more (71.1%) over combination therapy (34.44%). Sodium valproate (24.4%) was the most prescribed drug in monotherapy followed closely by Phenytoin (18.3%). Most prescribed two drug combination was of Sodium valproate and Carbamazepine (8.3%) followed by Phenytoin and Phenobarbitone (6.67%). Most common ADR was memory loss, hepatotoxicity, aggression and reduced learning. Sodium valproate was found to induce more number of ADRs followed by Carbamazepine and Phenytoin. Treatment with antiepileptic drugs was continued in all cases, except in three cases of skin rashes.

Assessment of quality of life in patients on antiepileptic drugs: a hospital based cross sectional study

“…Similar observations have been reported by Shobhana Mathur et al 12 Also similar results have been reported by other studies also. [13][14][15] This shows that the pattern of pharmacological therapy for epilepsy in these studies was similar to our study.…”

Test

“…The age groups in descending order contains followed by 18 (18%) from 30-39 years, 14 (14%) from 40-49 years, 5 (5%) from 50-59 years, and inally the least number of patients i.e., 1 (1%) from 60-69 years. The results are similar to the studies from Faizan Mazhar et al [4], Nurulumi Ahmad et al [22] and Kavitha Palanisamy et al [23].…”

“…In Nurulumi Ahmad et al [22], there were 24 (46.2%) patients under the age of 30 years, 22 (42.3%) patients between 30-60 years and 6 (11.5%) patients above 60 years. In Kavitha Palanisamy et al [23], patients between age group 0-14 years were dominant with 59 (32.78%) subjects followed by patients from the age group 15-29 years (25.55%). From this it is clearly evident that adults are more likely to have epilepsy than any other age group.…”

Study of adverse drug reactions associated with antiepileptic drugs: a pharmacovigilance study using spontaneous reporting system

“…From out study, it was found that the predominance of ADRs was in males than the females and similar findings were shown in the previous study by Singh et al but it is contrary to study of Alkhalil et al 1,8 The prevalence of ADRs due to AEDs is more in the middle-aged adult group which is contrary to Jayalekshmi et al but similar to the study by Gajjar et al 2,9 In our study the most of the ADRs due to AEDs belonged to SOC of 'skin and subcutaneous disorder's which is in line with the study of Khan et al, but differs from the study conducted by Singhal et al 10,11 In the study it was found that the most of the ADRs are implicated by phenytoin which was similar to the study of Khan et al, but contrary to the study of Rohit Singhal et al and Du et al [10][11][12] From the study it was found that the most of the ADRs were serious which is contrary to the study of Singhal et al and Du et al 11,12 In this study the WHO-UMC causality assessment scale was used and found that the most of the ADRs were under 'probable' category which is contrast to Du et al, but similar to study of Sari et al in which Naranjo's causality assessment scale was used. 12,13…”