Anticipated absolute effects * (95% CI) Outcomes Risk with non-PARPi regimen Risk with PARPi-containing regimen Relative effect (95% CI) № of participants (studies) Certainty of the evidence (GRADE) Comments Study population Overall Survival** follow up: 24 months 550 per 1,000 497 per 1,000 (446 to 550) HR 0.84 (0.76 to 1.00) 1435 (4 RCTs) ⊕⊕⊕⊕ HIGH 1 2 3 4 Study population Progression Free Survival** follow up: 12 months 625 per 1,000 461 per 1,000 (423 to 502) HR 0.63 (0.56 to 0.71) 1474 (5 RCTs) ⊕⊕⊕⊕ HIGH 1 3 5 6 Study population Response Rate 489 per 1,000 695 per 1,000 (636 to 749) RR 1.39 (1.24 to 1.54) 1185 (5 RCTs) ⊕⊕⊝⊝ LOW 1 3 6 7 Study population Grade ≥3 AEs 645 per 1,000 620 per 1,000 (555 to 684) RR 0.98 (0.91 to 1.04) 1443 (5 RCTs) ⊕⊕⊕⊝ MODERATE 1 3 8 9*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).** Given i) overall survival and progression-free survival are continuous endpoints in clinical practice but ii) that continuous measures are not easily quantifiable (even if the HR is available), we opted to estimate the percentage of patients with this outcome (e.g. death) at a predefined time interval to practically estimate the size of treatment benefit for readers. We extrapolated this information from Kaplan-Meier curves from the included studies. We started with the OS at 2 years, then subtracted this from 1 to arrive at incidence of death at 2 years and similarly for PFS at 1 year (BROCADE 2; BROCADE 3; EMBRACA; Kummar 2016; OLYMPIAD).
Cochrane
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