A Study On Sociodemographic Pattern And Side Effects Of Anti-Tubercular Drugs Among Tuberculosis Patients In Pokhara Valley

Bhattarai, Srijana; Thapa, Parbati; Shrestha, Chandrika Devi; Dangol, S; Niroula, T; Sc, Verma

doi:10.3126/saarctb.v10i2.9712

Cited by 2 publications

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References 8 publications

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“…In the present study, patients who had history of alcohol consumption and smoking experienced more ADR. Similar finding were found in the studies conducted by Bhattarai et al and Kurniawati et al 13,14 A research done by Schaberg et al found that 23% patients interrupted ATT because of severe ADR mainly pyrazinamide induced hepatotoxicity. 15…”

Section: Discussionsupporting

confidence: 87%

“…[10][11][12] However, the Bhattarai et al, Kurniawati et al and Schaberg et al reported that joint pain, skin reactions and hepatotoxicity as the most common ADR due to ATT respectively. [13][14][15] In this study, 74.4% experienced ADR among which 47.7% taken treatment for ADR and remaining 52.3% patients were reassured. Of the TB patients who experienced ADR, 9.0% of them had interrupted ATT, however they completed full course of ATT.…”

Section: Discussionmentioning

confidence: 91%

“…According to the study conducted by Bhattarai et al, 83.9% of the patients experienced ADR during ATT. 13 Kurniawati et al stated that, 15.8% patients had ADR in which 8.6% patients took medication for it and 6.1% patients interrupted ATT. 14 The occurrence of ADR due to ATT may be influenced by several risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Adverse drug reactions in patients taking anti tuberculosis therapy from directly observed treatment short course centre at Mandya Institute of Medical Sciences, Mandya: a cross sectional study

Kambale

Babu

Goud

et al. 2020

Int J Community Med Public Health

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Background: Ending the tuberculosis (TB) epidemic by 2030 is among the health targets of the sustainable development goals. Side effects to anti-TB drugs are common and may lead to reduced compliance to treatment. These adverse effects must be recognized early to reduce associated morbidity and mortality. Objective of this study was to determine the adverse drug reactions (ADR) to anti-tubercular therapy among patients visiting directly observed treatment, short-course (DOTS) centre MIMS, Mandya.Methods: A cross sectional study was conducted at DOTS Centre MIMS, Mandya. TB patients registered at DOTS Centre during the year 2018 were selected for the study. Verbal informed consent was taken from the TB patients and interviewed using pretested semi-structured questionnaire. Data analysis was done using descriptive statistics and chi square test.Results: Among the study population (n=90), 67 (74.4%) experienced ADR among which 47.7% took treatment for ADR and the remaining 52.3% patients were given reassurance. In this study, gastrointestinal manifestations (42.3%) were the most common adverse drug reaction (ADR). Of the TB patients who experienced ADR, 9.0% of them had interrupted ATT, however they completed full course of ATT.Conclusions: A considerable number of TB patients taking ATT experience ADRs and some of them may have to interrupt treatment. However, they need to be counselled or supervised with caution to complete their course of treatment to reduce the chances of treatment default and also reduce the occurrence of drug resistance.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 91%

See 1 more Smart Citation

Adverse drug reactions in patients taking anti tuberculosis therapy from directly observed treatment short course centre at Mandya Institute of Medical Sciences, Mandya: a cross sectional study

Kambale

Babu

Goud

et al. 2020

Int J Community Med Public Health

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“…In addition to the fact that the TB bacteria are not efficiently removed after inhalation, chronic lung damage impairs the lung immunity and might increase susceptibility to TB. 32 In support to the present study, Maiti et al had revealed that both smoking and alcoholism had independently and synergistically increased the TB severity significantly in urban and rural part of Eastern India. 33 Khan had suggested about 30-50% increased risk of TB in smokers.…”

Section: Discussionsupporting

confidence: 73%

Socio-economic profile and risk factors among pulmonary tuberculosis patients in Madurai, India: a cross sectional study

2015

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INTRODUCTIONIn today's world, Tuberculosis (TB) still remains as a major public health problem. In terms of incidence, the WHO South-East Asia Region (SEAR) accounted for 38% of the global burden of TB. According to the latest estimate in the year 2013, the occurrence of new TB cases were 3.4 million and deaths due to TB were about 4,40,000 each year. Five of the 11 Member countries of SEAR namely Bangladesh, India, Indonesia, Myanmar and Thailand were among the 22 countries in the world with high-burden of TB. India alone accounted for 23% of the world's incident TB cases and 21% of world deaths due to TB. Among all new TB cases detected in 2013 in ABSTRACT Background: This study has been carried out to assess the socio-economic profile and underlying risk factors of pulmonary tuberculosis (PTB) patients registered under RNTCP programme of India and to find the differences based on their residential place. Methods: The study design was cross sectional consisting of 167 PTB patients from three DOTS centres in Madurai, Tamilnadu during August 2015. Data was collected using a questionnaire that included personal details, socioeconomic and risk factors. Results: PTB was most prevalent in the age group of 35-54 years both in the urban (46.7%) and rural (49.4%) side. In the urban population, 67 (74.4%) were men whereas in the rural population they were 53 (68.8%). Maximum of the study subjects were from nuclear family (67.8% in urban and 89.6% in rural). About 20% of the patients studied were illiterates irrespective of their residential place. Labourers were 37% in urban area and 49% in rural area. Smoking, alcoholism and Diabetes Mellitus (DM) were more common among urban PTB patients while under-nutrition and poor housing among rural PTB patients. Conclusions:The study has concluded that the usual epidemiological pattern of PTB has been observed in both urban and rural setup as reported by other researchers. Socio-economic status and risk factors have played a vital role for treatment success. To eradicate Tuberculosis (TB), a holistic and interdisciplinary approach would be necessary to improve the socio-economic status along with proper screening and treatment of underlying risk factors. More precise health education and proper awareness programmes have to be implemented from the grass-root level to get rid of TB.

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A Study On Sociodemographic Pattern And Side Effects Of Anti-Tubercular Drugs Among Tuberculosis Patients In Pokhara Valley

Cited by 2 publications

References 8 publications

Adverse drug reactions in patients taking anti tuberculosis therapy from directly observed treatment short course centre at Mandya Institute of Medical Sciences, Mandya: a cross sectional study

Adverse drug reactions in patients taking anti tuberculosis therapy from directly observed treatment short course centre at Mandya Institute of Medical Sciences, Mandya: a cross sectional study

Socio-economic profile and risk factors among pulmonary tuberculosis patients in Madurai, India: a cross sectional study

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