A Study on Serum Carotenoid Levels in Breast Cancer Patients of Indian Women in Chennai (Madras), India

Ito, Yoshinori; Gajalakshmi, Kesavan C.; Sasaki, Ryuichiro; Suzuki, Kôji; Shanta, V.

doi:10.2188/jea.9.306

Cited by 21 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, patients with severe forms of cancer are reported to have lower concentrations of micronutrients in plasma. This has been shown for women with breast cancer [4] and cervical cancer [5], but no differences between women with benign breast tumors and breast cancer were observed [6]. These differences in plasma levels might be due to the association of cancerassociated inflammation with reduced plasma concentrations [7][8][9], to cachexia-associated changes in food intake, or due to general changes in metabolism [10].…”

Section: Introductionmentioning

confidence: 90%

Accumulation of Selected Carotenoids, α-Tocopherol and Retinol in Human Ovarian Carcinoma Ascitic Fluid

Schweigert

Raila²,

Sehouli³

et al. 2004

Ann Nutr Metab

View full text Add to dashboard Cite

Background: Patients with severe forms of cancer are reported to have reduced concentrations of micronutrients in plasma due to the chronic reduction of food intake and an increased metabolism of these components. The purpose of this study was to evaluate if an accumulation of carotenoids, α-tocopherol and retinol in malignant ascitic fluid in women with ovarian cancer might contribute to a loss of these components from plasma. Methods: Blood and ascitic fluid samples obtained from 21 women with ovarian carcinomas and 17 healthy controls were analyzed for retinol, retinol-binding protein (RBP), α-tocopherol and carotenoids. Results: Plasma concentrations of all micronutrients were lower in cancer patients compared to controls. Ascitic fluid concentration of all investigated components was comparable (73–110%) to plasma. While the mean concentration of retinol in malignant ascites represented 73% of that in plasma, the concentration of RBP was less than 10% resulting in an increased mean molar ratio of retinol to RBP from 1.18 to 10.5. Conclusions: The results suggest that lower plasma concentrations of micronutrients in women suffering from ovarian carcinoma are not only caused by a cachexia-induced decrease of food intake and a higher rate of metabolic utilization, but also by a substantial yet not considered transfer from plasma into ascitic fluid possibly associated with plasma lipoproteins. This raises questions with regard to the protective function of these plasma components in ascitic fluid, the consequences of paracentesis on an additional supplementation and finally the possibility to use one or a combination of these components as an additional marker to discriminate between benign and malignant ascites.

show abstract

Section: Introductionmentioning

confidence: 90%

Accumulation of Selected Carotenoids, α-Tocopherol and Retinol in Human Ovarian Carcinoma Ascitic Fluid

Schweigert

Raila²,

Sehouli³

et al. 2004

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Subsequent epidemiological, preclinical and clinical studies established a relationship between vitamin A deficiency and a higher incidence of carcinogenesis in both humans and rodents (Basu, Temple, & Hodgson, 1988; Chaudhy, Jafarey, & Ibrahim, 1980; S. C. Dogra, Khanduja, & Gupta, 1985; Ito, Gajalakshmi, Sasaki, Suzuki, & Shanta, 1999; Stehr, Gloninger, Kuller, Marsh, Radford, & Weinberg, 1985). In addition, abnormal RA metabolism potentially leading to altered RA levels has also been implicated in tumorigenesis (Moulas, Gerogianni, Papadopoulos, & Gourgoulianis, 2006; Osanai & Petkovich, 2005).…”

Section: Cyp26 and Retinoic Acid In Cancermentioning

confidence: 99%

Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer

Stevison

Jing

Tripathy

et al. 2015

Advances in Pharmacology

View full text Add to dashboard Cite

Vitamin A (retinol) and its active metabolite, all-trans-retinoic acid (atRA), play critical roles in regulating the differentiation, growth and migration of immune cells. Similarly, as critical signaling molecules in the regulation of the cell cycle, retinoids are important in cancers. Concentrations of atRA are tightly regulated in tissues, predominantly by the availability of retinol, synthesis of atRA by ALDH1A enzymes and metabolism and clearance of atRA by CYP26 enzymes. The ALDH1A and CYP26 enzymes are expressed in several cell types in the immune system and in cancer cells. In the immune system the ALDH1A and CYP26 enzymes appear to modulate RA concentrations. Consequently, alterations in the activity of ALDH1A and CYP26 enzymes are expected to change disease outcomes in inflammation. There is increasing evidence from various disease models of intestinal and skin inflammation that treatment with atRA has a positive effect on disease markers. However, whether aberrant atRA concentrations or atRA synthesis and metabolism play a role in inflammatory disease development and progression is not well understood. In cancers, especially in acute promyelocytic leukemia and neuroblastoma, increasing intracellular concentrations of atRA appears to provide clinical benefit. Inhibition of the CYP26 enzymes to increase atRA concentrations and combat therapy resistance has been pursued as a drug target in these cancers. This chapter covers the current knowledge of how atRA and retinol regulate the immune system and inflammation, how retinol and atRA metabolism is altered in inflammation and cancer and what roles atRA metabolizing enzymes have in immune responses and cancers.

show abstract

“…References to reactive oxidative stress, oxidative damage, and immunologic systems were emphasized in four (10%) of the studies (Hadley, Clinton, & Schwartz, 2003;McMillan et al, 2002;Pellegrini, Riso, & Porrini, 2000;Ringer et al, 1991), whereas the rest of the studies focused on nutrient serum levels and biochemical markers as their basis of comparison. Six of the studies (15%) examined bioavailability issues related to lycopene (Djuric & Powell, 2001;Edwards et al, 2003;Hadley et al;Ito, Gajalakshmi, Sasaki, Suzuki, & Shanta, 1999;Paetau et al, 1998;Porrini, Riso, & Testolin, 1998;Ronco et al, 1999). Six of the studies (15%) explored the antioxidant role of lycopene (Ching, Ingram, Hahnel, Beilby, & Rossi, 2002;La Vecchia, 2002;McMillan et al;Pellegrini et al;Rao & Agarwal, 1998;Ringer et al).…”

Section: Classifi Cation Of Researchmentioning

confidence: 99%

“…Because many of the studies looked at multiple variables of consideration in reference to dietary intake composition, the reporting of individual statistical tests was easy to understand. In addition, variables other than dietary intake were considered in many of the studies, such Ching et al, 2002Cohen et al, 1999Djuric & Powell, 2001Dorgan et al, 1998Edwards et al, 2003Freudenheim et al, 1996Hadley et al, 2003Horn-Ross et al, 2002Hulten et al, 2001Ito et al, 1999Jarvinen et al, 1997Karas et al, 2000La Vecchia, 2002Levi et al, 2001Levy et al, 1995London et al, 1992Mayne et al, 1999 McEligot, Aims and Purposes Rock, Shanks, et al, 1999McMillan et al, 2002Paetau et al, 1998Pellegrini et al, 2000Pierce et al, 2002Pierce et al, 2004Porrini et al, 1998Potischman et al, 1990Potischman et al, 1992Prakash et al, 2001 Rao & Agarwal, 1998Ringer et al, 1991Rock et al, 1997Ronco et al, 1999 predictors that might have affected serum measurements during course of study as well as the impact of a high-vegetable diet on breast cancer recurrence Dietary intervention to decrease risk of recurrence of breast cancer in women previously diagnosed in the Women's Healthy Eating and Living (WHEL) study Examination of the body's systemic infl ammatory response to reduced vitamin antioxidant concentrations in clients with common solid tumors Comparison of plasma responses from lycopene food sources and lycopene supplements and monitoring oxidation st...…”

Section: Classifi Cation Of Researchmentioning

confidence: 99%

“…Several of the studies examined selected factors as covariates in analysis ranging from other micronutrients, physical data calculations (e.g., anthropometrics, weight and body mass index), and demographic factors (Dorgan et al, 1998;Hulten et al, 2001;Ito et al, 1999;Jarvinen et al, 1997;La Vecchia, 2002;Levi et al, 2001;London et al, 1992;Rock et al, 1997;Sato et al, 2002;Terry et al, 2002;Toniolo et al, 2001;van Kappel et al, 2001;Zhang et al, 1997). Eleven of the studies (28%) included nutrient database calculations as part of their data collection based on dietary reference allowances defi ned by the U.S. Food and Drug Administration (Edwards et al, 2003;Freudenheim et al, 1996;Horn-Ross et al, 2002;Jarvinen et al;Levi et al;Mayne et al, 1999;McEligot, Rock, Shanks, et al, 1999;Pierce et al, 2002Pierce et al, , 2004Rock et al;Thomson et al, 2003).…”

Section: Integration Of Research Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Integrative Review of Lycopene and Breast Cancer

Wane

Lengacher²

2006

Oncology Nursing Forum

View full text Add to dashboard Cite

show abstract

A Study on Serum Carotenoid Levels in Breast Cancer Patients of Indian Women in Chennai (Madras), India

Cited by 21 publications

References 42 publications

Accumulation of Selected Carotenoids, α-Tocopherol and Retinol in Human Ovarian Carcinoma Ascitic Fluid

Accumulation of Selected Carotenoids, α-Tocopherol and Retinol in Human Ovarian Carcinoma Ascitic Fluid

Role of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer

Integrative Review of Lycopene and Breast Cancer

Contact Info

Product

Resources

About