In order to revitalize tourism, there are frequent attempts to introduce amphibious ships in the Republic of Korea. Overseas, amphibious ships are commercialized in the United States, United Kingdom, Australia, Singapore, Canada, etc. Safety cannot be verified in the Republic of Korea due to insufficient systems related to the inspection of amphibious ships. Therefore, in order to secure the safety of amphibious ships, this study presented standards for safe operation through investigations of domestic and foreign amphibious ships operating status and system status, and analysis of accidents related to domestic and foreign amphibious ships. This study proposed the provincial sea area, weather conditions, stability criteria, acquisition system of the number of boarding people, location of water ingress, and inspection period; however, a quantitative review of these criteria is suggested as a future research direction. If the amphibious ship safety implementations are achieved and can be commercialized through this study and further research, it is expected to vitalize the local economy by attracting tourists.